5-HT receptor subtypes involved in the spinal antinociceptive effect of acetaminophen in rats

The present study was designed to investigate which subtype of spinal 5-HT receptors were involved in acetaminophen-induced antinociception using the paw-pressure test. Propacetamol (prodrug of acetaminophen, 400 mg/kg, injected intravenously, corresponding to 200 mg/kg of acetaminophen) produced a...

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Veröffentlicht in:	European journal of pharmacology 2001-11, Vol.432 (1), p.1-7
Hauptverfasser:	Courade, Jean-Philippe, Chassaing, Claude, Bardin, Laurent, Alloui, Abdelkrim, Eschalier, Alain
Format:	Artikel
Sprache:	eng
Schlagworte:	5-HT receptor antagonist Acetaminophen Acetaminophen - pharmacology Analgesics Analgesics - pharmacology Animals Antinociception Biological and medical sciences Ergolines - pharmacology Granisetron - pharmacology Injections, Spinal Ketanserin - pharmacology Male Medical sciences Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pain Threshold - drug effects Paw-pressure test Penbutolol - pharmacology Pharmacology. Drug treatments Piperazines - pharmacology Pyridines - pharmacology Rats Rats, Sprague-Dawley Receptor, Serotonin, 5-HT1B Receptor, Serotonin, 5-HT2A Receptor, Serotonin, 5-HT2C Receptors, Serotonin - drug effects Receptors, Serotonin - physiology Receptors, Serotonin, 5-HT1 Receptors, Serotonin, 5-HT3 Serotonin Antagonists - pharmacology Serotoninergic system Time Factors Vocalization, Animal - drug effects
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