Functional diversity between orthologous myosins with minimal sequence diversity

To define the structural differences that are responsible for the functional diversity between orthologous sarcomeric myosins, we compared the rat and human beta/slow myosins. Functional comparison showed that rat beta/slow myosin has higher ATPase activity and moves actin filaments at higher speed...

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Veröffentlicht in:	Journal of muscle research and cell motility 2000-05, Vol.21 (4), p.375-382
Hauptverfasser:	Canepari, M, Rossi, R, Pellegrino, M A, Bottinelli, R, Schiaffino, S, Reggiani, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Adenosine Triphosphatases - metabolism Amino Acid Sequence Animals Genetic Variation Humans Molecular Sequence Data Myosin Heavy Chains - chemistry Myosin Heavy Chains - genetics Myosin Heavy Chains - metabolism Myosin Heavy Chains - physiology Proteins Rats Rats, Wistar Sarcomeres - chemistry Sequence Alignment
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