Red Cell Genetic Abnormalities, β-Globin Gene Haplotypes, and APOB Polymorphism in the Great Andamanese, A Primitive Negrito Tribe of Andaman and Nicobar Islands, India
The Great Andamanese are a primitive Negrito tribe of the Andaman and Nicobar Islands, India, with a total population of 37. We studied 29 individuals from eight families from this population for abnormal hemoglobins, G6PD deficiency, DNA haplotypes, and apolipoprotein B (APOB, gene) polymorphism. H...
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| Veröffentlicht in: | Human biology 2001-10, Vol.73 (5), p.739-744 |
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| creator | MURHEKAR, K.M. MURHEKAR, M.V. MUKHERJEE, M.B. GORAKSHAKAR, A.C. SURVE, R. WADIA, M. PHANASGAONKAR, S. SHRIDEVI, S. ROSHAN, B. COLAH MOHANTY, D. |
| description | The Great Andamanese are a primitive Negrito tribe of the Andaman and Nicobar Islands, India, with a total population of 37. We studied 29 individuals from eight families from this population for abnormal hemoglobins, G6PD deficiency, DNA haplotypes, and apolipoprotein B (APOB, gene) polymorphism. Hb E was detected in five individuals, the prevalence of Hb E heterozygotes being 14.3%. One individual had β-thalassemia trait. One female was G6PD deficient and showed the G6PD Orissa mutation. Haplotype analysis of the β-globin gene cluster showed that the βE chromosomes were linked to two haplotypes (---++and ++-+++) representing the framework 1 gene, whereas the βA chromosomes showed eight different haplotypic patterns corresponding to framework 1 and 3 genes. APOB polymorphism analysis showed that the 631-base-pair (bp) allele was the predominant one with a high homozygosity rate, which could be due to the higher rate of inbreeding in this isolated group. The presence of Hb E and our findings on haplotype analysis supports the hypothesis that the Great Andamanese are reasonably believed to be the surviving representatives of the Negrito race that once flourished in the entire Southeast Asian region in ancient times. |
| doi_str_mv | 10.1353/hub.2001.0070 |
| format | Article |
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COLAH ; MOHANTY, D.</creator><creatorcontrib>MURHEKAR, K.M. ; MURHEKAR, M.V. ; MUKHERJEE, M.B. ; GORAKSHAKAR, A.C. ; SURVE, R. ; WADIA, M. ; PHANASGAONKAR, S. ; SHRIDEVI, S. ; ROSHAN, B. COLAH ; MOHANTY, D.</creatorcontrib><description>The Great Andamanese are a primitive Negrito tribe of the Andaman and Nicobar Islands, India, with a total population of 37. We studied 29 individuals from eight families from this population for abnormal hemoglobins, G6PD deficiency, DNA haplotypes, and apolipoprotein B (APOB, gene) polymorphism. Hb E was detected in five individuals, the prevalence of Hb E heterozygotes being 14.3%. One individual had β-thalassemia trait. One female was G6PD deficient and showed the G6PD Orissa mutation. Haplotype analysis of the β-globin gene cluster showed that the βE chromosomes were linked to two haplotypes (---++and ++-+++) representing the framework 1 gene, whereas the βA chromosomes showed eight different haplotypic patterns corresponding to framework 1 and 3 genes. APOB polymorphism analysis showed that the 631-base-pair (bp) allele was the predominant one with a high homozygosity rate, which could be due to the higher rate of inbreeding in this isolated group. The presence of Hb E and our findings on haplotype analysis supports the hypothesis that the Great Andamanese are reasonably believed to be the surviving representatives of the Negrito race that once flourished in the entire Southeast Asian region in ancient times.</description><identifier>ISSN: 0018-7143</identifier><identifier>EISSN: 1534-6617</identifier><identifier>DOI: 10.1353/hub.2001.0070</identifier><identifier>PMID: 11758693</identifier><language>eng</language><publisher>United States: Wayne State University Press</publisher><subject>Adolescent ; Adult ; Alleles ; Apolipoproteins ; Apolipoproteins B - genetics ; beta-Thalassemia - ethnology ; beta-Thalassemia - genetics ; Brief Communications ; Child ; Chromosomes ; Consanguinity ; Continental Population Groups ; Demographic aspects ; DNA ; Erythrocytes - cytology ; Female ; Gene Frequency - genetics ; Genetic aspects ; Genetic Carrier Screening ; Genetic disorders ; Genetic mutation ; Genetic polymorphisms ; Genotype ; Genotypes ; Geography ; Globins - genetics ; Glucosephosphate Dehydrogenase Deficiency - ethnology ; Glucosephosphate Dehydrogenase Deficiency - genetics ; Haplotypes ; Haplotypes - genetics ; Hemoglobin E - genetics ; Homozygote ; Human population genetics ; Humans ; India - epidemiology ; Male ; Medical genetics ; Medical research ; Middle Aged ; Multigene family ; Multigene Family - genetics ; Oceanic Ancestry Group - genetics ; Oceanic Ancestry Group - statistics & numerical data ; Polymerase chain reaction ; Polymorphism, Genetic - genetics ; Prevalence</subject><ispartof>Human biology, 2001-10, Vol.73 (5), p.739-744</ispartof><rights>Copyright © 2001 Wayne State University Press</rights><rights>COPYRIGHT 2001 Wayne State University Press</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/41465999$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/41465999$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11758693$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MURHEKAR, K.M.</creatorcontrib><creatorcontrib>MURHEKAR, M.V.</creatorcontrib><creatorcontrib>MUKHERJEE, M.B.</creatorcontrib><creatorcontrib>GORAKSHAKAR, A.C.</creatorcontrib><creatorcontrib>SURVE, R.</creatorcontrib><creatorcontrib>WADIA, M.</creatorcontrib><creatorcontrib>PHANASGAONKAR, S.</creatorcontrib><creatorcontrib>SHRIDEVI, S.</creatorcontrib><creatorcontrib>ROSHAN, B. COLAH</creatorcontrib><creatorcontrib>MOHANTY, D.</creatorcontrib><title>Red Cell Genetic Abnormalities, β-Globin Gene Haplotypes, and APOB Polymorphism in the Great Andamanese, A Primitive Negrito Tribe of Andaman and Nicobar Islands, India</title><title>Human biology</title><addtitle>Hum Biol</addtitle><description>The Great Andamanese are a primitive Negrito tribe of the Andaman and Nicobar Islands, India, with a total population of 37. We studied 29 individuals from eight families from this population for abnormal hemoglobins, G6PD deficiency, DNA haplotypes, and apolipoprotein B (APOB, gene) polymorphism. Hb E was detected in five individuals, the prevalence of Hb E heterozygotes being 14.3%. One individual had β-thalassemia trait. One female was G6PD deficient and showed the G6PD Orissa mutation. Haplotype analysis of the β-globin gene cluster showed that the βE chromosomes were linked to two haplotypes (---++and ++-+++) representing the framework 1 gene, whereas the βA chromosomes showed eight different haplotypic patterns corresponding to framework 1 and 3 genes. APOB polymorphism analysis showed that the 631-base-pair (bp) allele was the predominant one with a high homozygosity rate, which could be due to the higher rate of inbreeding in this isolated group. The presence of Hb E and our findings on haplotype analysis supports the hypothesis that the Great Andamanese are reasonably believed to be the surviving representatives of the Negrito race that once flourished in the entire Southeast Asian region in ancient times.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Alleles</subject><subject>Apolipoproteins</subject><subject>Apolipoproteins B - genetics</subject><subject>beta-Thalassemia - ethnology</subject><subject>beta-Thalassemia - genetics</subject><subject>Brief Communications</subject><subject>Child</subject><subject>Chromosomes</subject><subject>Consanguinity</subject><subject>Continental Population Groups</subject><subject>Demographic aspects</subject><subject>DNA</subject><subject>Erythrocytes - cytology</subject><subject>Female</subject><subject>Gene Frequency - genetics</subject><subject>Genetic aspects</subject><subject>Genetic Carrier Screening</subject><subject>Genetic disorders</subject><subject>Genetic mutation</subject><subject>Genetic polymorphisms</subject><subject>Genotype</subject><subject>Genotypes</subject><subject>Geography</subject><subject>Globins - genetics</subject><subject>Glucosephosphate Dehydrogenase Deficiency - ethnology</subject><subject>Glucosephosphate Dehydrogenase Deficiency - genetics</subject><subject>Haplotypes</subject><subject>Haplotypes - genetics</subject><subject>Hemoglobin E - genetics</subject><subject>Homozygote</subject><subject>Human population genetics</subject><subject>Humans</subject><subject>India - epidemiology</subject><subject>Male</subject><subject>Medical genetics</subject><subject>Medical research</subject><subject>Middle Aged</subject><subject>Multigene family</subject><subject>Multigene Family - genetics</subject><subject>Oceanic Ancestry Group - genetics</subject><subject>Oceanic Ancestry Group - statistics & numerical data</subject><subject>Polymerase chain reaction</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Prevalence</subject><issn>0018-7143</issn><issn>1534-6617</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0kFv0zAUB_AIgVg3OHIE-YR2aIodO4lzDBV0laq2gnGOnPgl9eTExXYQ_Uhc-SB8Jrx1Q6rUA_LB8vNPz_LfjqI3BM8ITemH3VjPEozJDOMcP4smJKUszjKSP48moczjnDB6EV06dxeWhHP-MrogJE95VtBJ9OsLSDQHrdECBvCqQWU9GNsLrbwCN0V_fscLbWo1PAB0I_ba-MP-fksMEpXbzUe0NfrQG7vfKdejIP0O0MKC8KgcpOjFAA6mqERbq_rQ9gegNXRWeYNuraoBmfYJPvRcq8bUwqKl02EZDloOUolX0YtWaAevH-er6NvnT7fzm3i1WSzn5SruGM59zLI6FYwxgYsmb0MoLWcSSy4lhTYvWlJzRguepVmdiEYUXBY4oUBbgrMMC0GvovfHvntrvo_gfNUr14SEwjXM6Ko8oUnIlAQ4PcJOaKjU0BpvRdOFlKzQZoBWhXLJMccpzu95fIaHIaEPFz7jr098IB5--k6MzlXLr-v_pXyxOqHTc7QxWkMHVUhyvjnh7x7DGOseZLUPLyjsoXr6QAG8PYI75439t88Iy9KiKOhf9LvOhA</recordid><startdate>20011001</startdate><enddate>20011001</enddate><creator>MURHEKAR, K.M.</creator><creator>MURHEKAR, M.V.</creator><creator>MUKHERJEE, M.B.</creator><creator>GORAKSHAKAR, A.C.</creator><creator>SURVE, R.</creator><creator>WADIA, M.</creator><creator>PHANASGAONKAR, S.</creator><creator>SHRIDEVI, S.</creator><creator>ROSHAN, B. COLAH</creator><creator>MOHANTY, D.</creator><general>Wayne State University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>8GL</scope><scope>ISN</scope><scope>7X8</scope></search><sort><creationdate>20011001</creationdate><title>Red Cell Genetic Abnormalities, β-Globin Gene Haplotypes, and APOB Polymorphism in the Great Andamanese, A Primitive Negrito Tribe of Andaman and Nicobar Islands, India</title><author>MURHEKAR, K.M. ; MURHEKAR, M.V. ; MUKHERJEE, M.B. ; GORAKSHAKAR, A.C. ; SURVE, R. ; WADIA, M. ; PHANASGAONKAR, S. ; SHRIDEVI, S. ; ROSHAN, B. COLAH ; MOHANTY, D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g407t-46b5a444a09c7f007f84d0d8dd3ef79f1b84398656b2aca98d9023e3f10660aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Alleles</topic><topic>Apolipoproteins</topic><topic>Apolipoproteins B - genetics</topic><topic>beta-Thalassemia - ethnology</topic><topic>beta-Thalassemia - genetics</topic><topic>Brief Communications</topic><topic>Child</topic><topic>Chromosomes</topic><topic>Consanguinity</topic><topic>Continental Population Groups</topic><topic>Demographic aspects</topic><topic>DNA</topic><topic>Erythrocytes - cytology</topic><topic>Female</topic><topic>Gene Frequency - genetics</topic><topic>Genetic aspects</topic><topic>Genetic Carrier Screening</topic><topic>Genetic disorders</topic><topic>Genetic mutation</topic><topic>Genetic polymorphisms</topic><topic>Genotype</topic><topic>Genotypes</topic><topic>Geography</topic><topic>Globins - genetics</topic><topic>Glucosephosphate Dehydrogenase Deficiency - ethnology</topic><topic>Glucosephosphate Dehydrogenase Deficiency - genetics</topic><topic>Haplotypes</topic><topic>Haplotypes - genetics</topic><topic>Hemoglobin E - genetics</topic><topic>Homozygote</topic><topic>Human population genetics</topic><topic>Humans</topic><topic>India - epidemiology</topic><topic>Male</topic><topic>Medical genetics</topic><topic>Medical research</topic><topic>Middle Aged</topic><topic>Multigene family</topic><topic>Multigene Family - genetics</topic><topic>Oceanic Ancestry Group - genetics</topic><topic>Oceanic Ancestry Group - statistics & numerical data</topic><topic>Polymerase chain reaction</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Prevalence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MURHEKAR, K.M.</creatorcontrib><creatorcontrib>MURHEKAR, M.V.</creatorcontrib><creatorcontrib>MUKHERJEE, M.B.</creatorcontrib><creatorcontrib>GORAKSHAKAR, A.C.</creatorcontrib><creatorcontrib>SURVE, R.</creatorcontrib><creatorcontrib>WADIA, M.</creatorcontrib><creatorcontrib>PHANASGAONKAR, S.</creatorcontrib><creatorcontrib>SHRIDEVI, S.</creatorcontrib><creatorcontrib>ROSHAN, B. COLAH</creatorcontrib><creatorcontrib>MOHANTY, D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Gale In Context: High School</collection><collection>Gale In Context: Canada</collection><collection>MEDLINE - Academic</collection><jtitle>Human biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MURHEKAR, K.M.</au><au>MURHEKAR, M.V.</au><au>MUKHERJEE, M.B.</au><au>GORAKSHAKAR, A.C.</au><au>SURVE, R.</au><au>WADIA, M.</au><au>PHANASGAONKAR, S.</au><au>SHRIDEVI, S.</au><au>ROSHAN, B. COLAH</au><au>MOHANTY, D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Red Cell Genetic Abnormalities, β-Globin Gene Haplotypes, and APOB Polymorphism in the Great Andamanese, A Primitive Negrito Tribe of Andaman and Nicobar Islands, India</atitle><jtitle>Human biology</jtitle><addtitle>Hum Biol</addtitle><date>2001-10-01</date><risdate>2001</risdate><volume>73</volume><issue>5</issue><spage>739</spage><epage>744</epage><pages>739-744</pages><issn>0018-7143</issn><eissn>1534-6617</eissn><abstract>The Great Andamanese are a primitive Negrito tribe of the Andaman and Nicobar Islands, India, with a total population of 37. We studied 29 individuals from eight families from this population for abnormal hemoglobins, G6PD deficiency, DNA haplotypes, and apolipoprotein B (APOB, gene) polymorphism. Hb E was detected in five individuals, the prevalence of Hb E heterozygotes being 14.3%. One individual had β-thalassemia trait. One female was G6PD deficient and showed the G6PD Orissa mutation. Haplotype analysis of the β-globin gene cluster showed that the βE chromosomes were linked to two haplotypes (---++and ++-+++) representing the framework 1 gene, whereas the βA chromosomes showed eight different haplotypic patterns corresponding to framework 1 and 3 genes. APOB polymorphism analysis showed that the 631-base-pair (bp) allele was the predominant one with a high homozygosity rate, which could be due to the higher rate of inbreeding in this isolated group. The presence of Hb E and our findings on haplotype analysis supports the hypothesis that the Great Andamanese are reasonably believed to be the surviving representatives of the Negrito race that once flourished in the entire Southeast Asian region in ancient times.</abstract><cop>United States</cop><pub>Wayne State University Press</pub><pmid>11758693</pmid><doi>10.1353/hub.2001.0070</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Adult Alleles Apolipoproteins Apolipoproteins B - genetics beta-Thalassemia - ethnology beta-Thalassemia - genetics Brief Communications Child Chromosomes Consanguinity Continental Population Groups Demographic aspects DNA Erythrocytes - cytology Female Gene Frequency - genetics Genetic aspects Genetic Carrier Screening Genetic disorders Genetic mutation Genetic polymorphisms Genotype Genotypes Geography Globins - genetics Glucosephosphate Dehydrogenase Deficiency - ethnology Glucosephosphate Dehydrogenase Deficiency - genetics Haplotypes Haplotypes - genetics Hemoglobin E - genetics Homozygote Human population genetics Humans India - epidemiology Male Medical genetics Medical research Middle Aged Multigene family Multigene Family - genetics Oceanic Ancestry Group - genetics Oceanic Ancestry Group - statistics & numerical data Polymerase chain reaction Polymorphism, Genetic - genetics Prevalence |
| title | Red Cell Genetic Abnormalities, β-Globin Gene Haplotypes, and APOB Polymorphism in the Great Andamanese, A Primitive Negrito Tribe of Andaman and Nicobar Islands, India |
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