Transforming Growth Factor β Inhibits the Phosphorylation of pRB at Multiple Serine/Threonine Sites and Differentially Regulates the Formation of pRB Family–E2F Complexes in Human Myeloid Leukemia Cells

Transforming growth factor β (TGFβ)1 induced dephosphorylation of pRb at multiple serine and threonine residues including Ser249/Thr252, Thr373, Ser780, and Ser807/811 in MV4-11 cells. Likewise, TGFβ1 caused the dephosphorylation of p130, while inhibiting accumulation of p107 protein. Phosphorylated...

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Veröffentlicht in:	Biochemical and biophysical research communications 2000-10, Vol.276 (3), p.930-939
Hauptverfasser:	Hu, Xiaotang, Cress, W.Douglas, Zhong, Qing, Zuckerman, Kenneth S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Blotting, Western Carrier Proteins cell cycle Cell Cycle - drug effects Cell Cycle Proteins Cell Division - drug effects Cell Line DNA - genetics DNA - metabolism DNA-Binding Proteins - metabolism E2F Transcription Factors E2F1 Transcription Factor E2F3 Transcription Factor E2F4 Transcription Factor Gene Expression Regulation - drug effects Humans Leukemia, Myeloid - metabolism Leukemia, Myeloid - pathology Macromolecular Substances Myeloid Cells - cytology Myeloid Cells - drug effects Myeloid Cells - metabolism Nuclear Proteins - biosynthesis Nuclear Proteins - metabolism Phosphoproteins - metabolism Phosphorylation - drug effects pRb Precipitin Tests Protein Binding - drug effects Proteins Retinoblastoma Protein - metabolism Retinoblastoma-Binding Protein 1 Retinoblastoma-Like Protein p107 Retinoblastoma-Like Protein p130 Serine - metabolism Threonine - metabolism Time Factors transcription factor Transcription Factor DP1 Transcription Factors - metabolism transforming growth factor Transforming Growth Factor beta - pharmacology Transforming Growth Factor beta1 Tumor Cells, Cultured
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