Nucleoside phosphate analogues of biological interest, and their synthesis via aryl nucleoside H-phosphonates as intermediates
This review presents a brief account of the chemistry and mechanistic aspects of aryl H-phosphonates, and selected applications of this class of compounds as intermediates in the synthesis of a wide range of biologically important analogues of nucleoside phosphates, and oligonucleotides, in which th...
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| Veröffentlicht in: | Acta biochimica polonica 2001-01, Vol.48 (2), p.429-442 |
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| container_end_page | 442 |
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| container_issue | 2 |
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| container_title | Acta biochimica polonica |
| container_volume | 48 |
| creator | Cieślak, J Sobkowski, M Jankowska, J Wenska, M Szymczak, M Imiolczyk, B Zagórowska, I Shugar, D Stawiński, J Kraszewski, A |
| description | This review presents a brief account of the chemistry and mechanistic aspects of aryl H-phosphonates, and selected applications of this class of compounds as intermediates in the synthesis of a wide range of biologically important analogues of nucleoside phosphates, and oligonucleotides, in which the phosphate moieties are replaced by other structurally related groups. The aryl nucleoside H-phosphonates, compounds of controlled reactivity, have proven to be more versatile and superior to various mixed anhydrides as synthetic intermediates, particularly for preparation of nucleotide analogues bearing P-N or P-S bonds in various configurational arrangements at the phosphate moiety. |
| doi_str_mv | 10.18388/abp.2001_3927 |
| format | Article |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Catalysis Esterification Methods Molecular Structure Nucleotides - chemical synthesis Nucleotides - chemistry Phosphates - chemistry |
| title | Nucleoside phosphate analogues of biological interest, and their synthesis via aryl nucleoside H-phosphonates as intermediates |
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