Signaling: cellular insights into the pathophysiology of bipolar disorder

Clinical studies over the years have provided evidence that monoamine signaling and hypothalamic–pituitary–adrenal axis disruption are integral to the pathophysiology of bipolar disorder. A full understanding of the pathophysiology from a molecular to a systems level must await the identification of...

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Veröffentlicht in:	Biological psychiatry (1969) 2000-09, Vol.48 (6), p.518-530
Hauptverfasser:	Manji, Husseini K, Lenox, Robert H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Antipsychotic Agents - pharmacology Biological and medical sciences Bipolar disorder Bipolar Disorder - drug therapy Bipolar Disorder - metabolism Bipolar Disorder - physiopathology Bipolar disorders Brain - drug effects Brain - metabolism Brain - physiopathology Cyclic AMP-Dependent Protein Kinases - metabolism G proteins GTP-Binding Proteins - metabolism Humans Ion Pumps - metabolism lithium Lithium - pharmacology Medical sciences Mood disorders Neural Pathways - drug effects Neural Pathways - metabolism protein kinase A protein kinase C Protein Kinase C - metabolism Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry signal transduction Signal Transduction - drug effects
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