Expression Profiling of Human Sulfotransferase and Sulfatase Gene Superfamilies in Epithelial Tissues and Cultured Cells

The bioavailability of drugs administered topically or orally depends on their metabolism by epithelial enzymes such as the cytosolic sulfotransferases (SULT). Reverse transcriptase-polymerase chain reaction (RT-PCR) methods were established to detect expression of 8 SULT genes and 4 arylsulfatase (...

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Veröffentlicht in:	Biochemical and biophysical research communications 2000-10, Vol.277 (1), p.236-245
Hauptverfasser:	Dooley, Thomas P., Haldeman-Cahill, Ruth, Joiner, Julie, Wilborn, Teresa W.
Format:	Artikel
Sprache:	eng
Schlagworte:	ARS gene arylsulfatase Biological Availability catecholamines Cell Transformation, Neoplastic - genetics Cells, Cultured Cholesterol - metabolism cholesterol sulfate Cytoplasm - enzymology Cytoplasm - metabolism DNA Primers drug metabolism Epithelial Cells - cytology Epithelial Cells - enzymology Epithelial Cells - metabolism Epithelium - enzymology Epithelium - metabolism Female fibroblasts gastrointestinal Gene Expression Profiling Gene Expression Regulation, Enzymologic Humans Isoenzymes - genetics keratinocytes Male melanocytes minoxidil Minoxidil - metabolism Neoplasm Proteins - genetics Organ Specificity Promoter Regions, Genetic - genetics Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis RNA, Messenger - metabolism skin Sulfatases - genetics sulfotransferase Sulfotransferases - genetics SULT gene Tumor Cells, Cultured
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