The activity of low-clearance liposomal amikacin in experimental murine tuberculosis

Most of the amikacin in low-clearance liposomal amikacin is excreted very slowly, offering the possibility of maintaining effective treatment of pulmonary tuberculosis with widely separated supervised doses. As a preliminary to explorations in humans, its efficacy was assessed in acute experimental...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2001-12, Vol.48 (6), p.869-876
Hauptverfasser:	Dhillon, Jasvir, Fielding, Robert, Adler-Moore, Jill, Goodall, Ruth L., Mitchison, Denis
Format:	Artikel
Sprache:	eng
Schlagworte:	Amikacin - administration & dosage Amikacin - blood Amikacin - pharmacokinetics Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - blood Anti-Bacterial Agents - pharmacokinetics Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Female Liposomes Lung - drug effects Lung - metabolism Lung - microbiology Medical sciences Mice Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - metabolism Pharmacology. Drug treatments Spleen - drug effects Spleen - metabolism Spleen - microbiology Tuberculosis - drug therapy Tuberculosis - metabolism
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