Sustained release of human growth hormone (hGH) from collagen film and evaluation of effect on wound healing in db/db mice

Collagen films containing human growth hormone (hGH) were prepared and the release of hGH from these films and their effect on healing of full-thickness wounds in db/db mice were evaluated. The release profiles of hGH from the collagen films varied with composition and preparation conditions. The fi...

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Veröffentlicht in:	Journal of controlled release 2001-12, Vol.77 (3), p.261-272
Hauptverfasser:	Maeda, Miho, Kadota, Keiichi, Kajihara, Masako, Sano, Akihiko, Fujioka, Keiji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Chemistry, Pharmaceutical Collagen Collagen - administration & dosage Collagen - pharmacokinetics Delayed-Action Preparations - pharmacokinetics Drug Evaluation, Preclinical - methods Film formulation General pharmacology Human growth hormone Human Growth Hormone - administration & dosage Human Growth Hormone - blood Human Growth Hormone - pharmacokinetics Humans Male Medical sciences Mice Mice, Inbred C57BL Mice, Mutant Strains Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Skin, nail, hair, dermoskeleton Sustained release Wound healing Wound Healing - drug effects Wound Healing - physiology
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