Ganglioside GD3 and Its Mimetics Induce Cytochrome c Release from Mitochondria

Ganglioside GD3 induced the release of cytochrome c from isolated rat liver mitochondria. This process was completely prevented by cyclosporin A and partially prevented by a cysteine protease inhibitor, n-acetyl-leu-leu-norleucinal. Cyclosporin A is a potent inhibitor of the permeability transition...

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Veröffentlicht in:	Biochemical and biophysical research communications 2000-10, Vol.276 (3), p.1210-1216
Hauptverfasser:	Inoki, Yutaka, Miura, Tsuyoshi, Kajimoto, Tetsuya, Kawase, Mitsuo, Kawase, Yuji, Yoshida, Yasuko, Tsuji, Shuichi, Kinouchi, Tadatoshi, Endo, Hitoshi, Kagawa, Yasuo, Hamamoto, Toshiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals apoptosis Blotting, Western Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone - pharmacology Cell-Free System Cyclosporine - pharmacology cystein protease Cysteine Endopeptidases - metabolism Cysteine Proteinase Inhibitors - pharmacology cytochrome c Cytochrome c Group - metabolism Dose-Response Relationship, Drug Egtazic Acid - pharmacology gangliosides Gangliosides - pharmacology Ion Channels Leupeptins - pharmacology Membrane Proteins - antagonists & inhibitors Membrane Proteins - metabolism Mitochondria, Liver - drug effects Mitochondria, Liver - enzymology Mitochondria, Liver - metabolism Mitochondrial Membrane Transport Proteins mitochondrial permeability transition Molecular Mimicry Oligomycins - pharmacology Rats
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