Natural residues versus antiretroviral drug-selected mutations in HIV type 1 group O reverse transcriptase and protease related to virological drug failure in vivo

HIV-1 group O viruses were first recognized as a distinct subgroup of HIV-1 with the isolation and characterization in 1990 of a virus (ANT70) from a woman (individual A) and her spouse (individual B), both from Cameroon (De Leys R, et al.: J Virol 1990;64:1207-1216). During the 5-6 years before tre...

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Veröffentlicht in:	AIDS research and human retroviruses 2000-09, Vol.16 (14), p.1385-1394
Hauptverfasser:	DE BAAR, Michel P, JANSSENS, Wouter, DE RONDE, Anthony, FRANSEN, Katrien, COLEBUNDERS, Robert, KESTENS, Luc, VAN DER GROEN, Guido, GOUDSMIT, Jaap
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Amino Acid Sequence Anti-HIV Agents - pharmacology Anti-HIV Agents - therapeutic use Base Sequence Biological and medical sciences CD4 Lymphocyte Count Drug Resistance, Microbial Drug Therapy, Combination Female HIV Infections - drug therapy HIV Infections - virology HIV Protease - genetics HIV Reverse Transcriptase - genetics HIV-1 - classification HIV-1 - drug effects HIV-1 - enzymology HIV-1 - genetics Human immunodeficiency virus 1 Human viral diseases Humans Infectious diseases Male Medical sciences Molecular Sequence Data Mutation Polymerase Chain Reaction Reverse Transcriptase Inhibitors - pharmacology Reverse Transcriptase Inhibitors - therapeutic use RNA, Viral - blood Self-Sustained Sequence Replication - methods Sequence Analysis, DNA Treatment Failure Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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