Genetics of autism: complex aetiology for a heterogeneous disorder
Since autism was first recognized as a disorder in 1943, speculation about its aetiology has ranged from biological to psychological and back again. After twin studies during the 1970s and 1980s yielded unequivocal evidence for a genetic component, aetiological research in autism began to focus prim...
Gespeichert in:
| Veröffentlicht in: | Nature reviews. Genetics 2001-12, Vol.2 (12), p.943-955 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 955 |
|---|---|
| container_issue | 12 |
| container_start_page | 943 |
| container_title | Nature reviews. Genetics |
| container_volume | 2 |
| creator | Folstein, S E Rosen-Sheidley, B |
| description | Since autism was first recognized as a disorder in 1943, speculation about its aetiology has ranged from biological to psychological and back again. After twin studies during the 1970s and 1980s yielded unequivocal evidence for a genetic component, aetiological research in autism began to focus primarily on uncovering the genetic mechanisms involved. The identification of chromosomal abnormalities and Mendelian syndromes among individuals with autism, in conjunction with data from genome screens and candidate-gene studies, has helped to refine the view of the complex genetics that underlies autism spectrum conditions. |
| doi_str_mv | 10.1038/35103559 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_72323937</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72323937</sourcerecordid><originalsourceid>FETCH-LOGICAL-p265t-a148ee68a6951a32dfe0b9ff97af55c1dfce3d3f78dd819f3e0748466ab76fec3</originalsourceid><addsrcrecordid>eNqFkE1LxDAQhoMo7roK_gIJHrxVk06TNN500VVY8KLnkm0ma5d2U5MW3H9v8OvgxdMzMM8MMy8hp5xdcgblFYgEIfQemfJC8YwxWez_1kJOyFGMG8a45AoOyYQngCrUlNwucItDU0fqHTXj0MTumta-61t8pyZ1fOvXO-p8oIa-4oDBr9OEHyO1TfTBYjgmB860EU--OSMv93fP84ds-bR4nN8ssz6XYsgML0pEWRqpBTeQW4dspZ3Tyjgham5djWDBqdLakmsHyFRRFlKalZIOa5iRi6-9ffBvI8ah6ppYY9uaz3sqlUMOGtS_Ii-BSQ4iied_xI0fwzY9UeU5KAFSyySdfUvjqkNb9aHpTNhVPxnCB-eFcXc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>223753696</pqid></control><display><type>article</type><title>Genetics of autism: complex aetiology for a heterogeneous disorder</title><source>MEDLINE</source><source>Nature</source><source>SpringerLink Journals - AutoHoldings</source><creator>Folstein, S E ; Rosen-Sheidley, B</creator><creatorcontrib>Folstein, S E ; Rosen-Sheidley, B</creatorcontrib><description>Since autism was first recognized as a disorder in 1943, speculation about its aetiology has ranged from biological to psychological and back again. After twin studies during the 1970s and 1980s yielded unequivocal evidence for a genetic component, aetiological research in autism began to focus primarily on uncovering the genetic mechanisms involved. The identification of chromosomal abnormalities and Mendelian syndromes among individuals with autism, in conjunction with data from genome screens and candidate-gene studies, has helped to refine the view of the complex genetics that underlies autism spectrum conditions.</description><identifier>ISSN: 1471-0056</identifier><identifier>EISSN: 1471-0064</identifier><identifier>DOI: 10.1038/35103559</identifier><identifier>PMID: 11733747</identifier><language>eng</language><publisher>England: Nature Publishing Group</publisher><subject>Autistic children ; Autistic Disorder - etiology ; Autistic Disorder - genetics ; Child & adolescent psychiatry ; chromosome 16 ; chromosome 2 ; chromosome 7 ; Chromosome Mapping ; DBH gene ; Etiology ; Eye contact ; Female ; FOXP2 gene ; GABRB3 gene ; Genetic Counseling ; Genetics ; Genome, Human ; Genomes ; GRIK2 gene ; Humans ; Male ; Neuropathology ; Parents & parenting ; Pathophysiology ; Phenotype ; RAY1 gene ; RELN gene ; Schizophrenia ; Social isolation ; SPCH1 gene ; Speech ; ST7 gene ; Twins ; UBE3A gene ; wnt2 gene</subject><ispartof>Nature reviews. Genetics, 2001-12, Vol.2 (12), p.943-955</ispartof><rights>Copyright Nature Publishing Group Dec 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27906,27907</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11733747$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Folstein, S E</creatorcontrib><creatorcontrib>Rosen-Sheidley, B</creatorcontrib><title>Genetics of autism: complex aetiology for a heterogeneous disorder</title><title>Nature reviews. Genetics</title><addtitle>Nat Rev Genet</addtitle><description>Since autism was first recognized as a disorder in 1943, speculation about its aetiology has ranged from biological to psychological and back again. After twin studies during the 1970s and 1980s yielded unequivocal evidence for a genetic component, aetiological research in autism began to focus primarily on uncovering the genetic mechanisms involved. The identification of chromosomal abnormalities and Mendelian syndromes among individuals with autism, in conjunction with data from genome screens and candidate-gene studies, has helped to refine the view of the complex genetics that underlies autism spectrum conditions.</description><subject>Autistic children</subject><subject>Autistic Disorder - etiology</subject><subject>Autistic Disorder - genetics</subject><subject>Child & adolescent psychiatry</subject><subject>chromosome 16</subject><subject>chromosome 2</subject><subject>chromosome 7</subject><subject>Chromosome Mapping</subject><subject>DBH gene</subject><subject>Etiology</subject><subject>Eye contact</subject><subject>Female</subject><subject>FOXP2 gene</subject><subject>GABRB3 gene</subject><subject>Genetic Counseling</subject><subject>Genetics</subject><subject>Genome, Human</subject><subject>Genomes</subject><subject>GRIK2 gene</subject><subject>Humans</subject><subject>Male</subject><subject>Neuropathology</subject><subject>Parents & parenting</subject><subject>Pathophysiology</subject><subject>Phenotype</subject><subject>RAY1 gene</subject><subject>RELN gene</subject><subject>Schizophrenia</subject><subject>Social isolation</subject><subject>SPCH1 gene</subject><subject>Speech</subject><subject>ST7 gene</subject><subject>Twins</subject><subject>UBE3A gene</subject><subject>wnt2 gene</subject><issn>1471-0056</issn><issn>1471-0064</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkE1LxDAQhoMo7roK_gIJHrxVk06TNN500VVY8KLnkm0ma5d2U5MW3H9v8OvgxdMzMM8MMy8hp5xdcgblFYgEIfQemfJC8YwxWez_1kJOyFGMG8a45AoOyYQngCrUlNwucItDU0fqHTXj0MTumta-61t8pyZ1fOvXO-p8oIa-4oDBr9OEHyO1TfTBYjgmB860EU--OSMv93fP84ds-bR4nN8ssz6XYsgML0pEWRqpBTeQW4dspZ3Tyjgham5djWDBqdLakmsHyFRRFlKalZIOa5iRi6-9ffBvI8ah6ppYY9uaz3sqlUMOGtS_Ii-BSQ4iied_xI0fwzY9UeU5KAFSyySdfUvjqkNb9aHpTNhVPxnCB-eFcXc</recordid><startdate>200112</startdate><enddate>200112</enddate><creator>Folstein, S E</creator><creator>Rosen-Sheidley, B</creator><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>200112</creationdate><title>Genetics of autism: complex aetiology for a heterogeneous disorder</title><author>Folstein, S E ; Rosen-Sheidley, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p265t-a148ee68a6951a32dfe0b9ff97af55c1dfce3d3f78dd819f3e0748466ab76fec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Autistic children</topic><topic>Autistic Disorder - etiology</topic><topic>Autistic Disorder - genetics</topic><topic>Child & adolescent psychiatry</topic><topic>chromosome 16</topic><topic>chromosome 2</topic><topic>chromosome 7</topic><topic>Chromosome Mapping</topic><topic>DBH gene</topic><topic>Etiology</topic><topic>Eye contact</topic><topic>Female</topic><topic>FOXP2 gene</topic><topic>GABRB3 gene</topic><topic>Genetic Counseling</topic><topic>Genetics</topic><topic>Genome, Human</topic><topic>Genomes</topic><topic>GRIK2 gene</topic><topic>Humans</topic><topic>Male</topic><topic>Neuropathology</topic><topic>Parents & parenting</topic><topic>Pathophysiology</topic><topic>Phenotype</topic><topic>RAY1 gene</topic><topic>RELN gene</topic><topic>Schizophrenia</topic><topic>Social isolation</topic><topic>SPCH1 gene</topic><topic>Speech</topic><topic>ST7 gene</topic><topic>Twins</topic><topic>UBE3A gene</topic><topic>wnt2 gene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Folstein, S E</creatorcontrib><creatorcontrib>Rosen-Sheidley, B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature reviews. Genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Folstein, S E</au><au>Rosen-Sheidley, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetics of autism: complex aetiology for a heterogeneous disorder</atitle><jtitle>Nature reviews. Genetics</jtitle><addtitle>Nat Rev Genet</addtitle><date>2001-12</date><risdate>2001</risdate><volume>2</volume><issue>12</issue><spage>943</spage><epage>955</epage><pages>943-955</pages><issn>1471-0056</issn><eissn>1471-0064</eissn><abstract>Since autism was first recognized as a disorder in 1943, speculation about its aetiology has ranged from biological to psychological and back again. After twin studies during the 1970s and 1980s yielded unequivocal evidence for a genetic component, aetiological research in autism began to focus primarily on uncovering the genetic mechanisms involved. The identification of chromosomal abnormalities and Mendelian syndromes among individuals with autism, in conjunction with data from genome screens and candidate-gene studies, has helped to refine the view of the complex genetics that underlies autism spectrum conditions.</abstract><cop>England</cop><pub>Nature Publishing Group</pub><pmid>11733747</pmid><doi>10.1038/35103559</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1471-0056 |
| ispartof | Nature reviews. Genetics, 2001-12, Vol.2 (12), p.943-955 |
| issn | 1471-0056 1471-0064 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72323937 |
| source | MEDLINE; Nature; SpringerLink Journals - AutoHoldings |
| subjects | Autistic children Autistic Disorder - etiology Autistic Disorder - genetics Child & adolescent psychiatry chromosome 16 chromosome 2 chromosome 7 Chromosome Mapping DBH gene Etiology Eye contact Female FOXP2 gene GABRB3 gene Genetic Counseling Genetics Genome, Human Genomes GRIK2 gene Humans Male Neuropathology Parents & parenting Pathophysiology Phenotype RAY1 gene RELN gene Schizophrenia Social isolation SPCH1 gene Speech ST7 gene Twins UBE3A gene wnt2 gene |
| title | Genetics of autism: complex aetiology for a heterogeneous disorder |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T08%3A59%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Genetics%20of%20autism:%20complex%20aetiology%20for%20a%20heterogeneous%20disorder&rft.jtitle=Nature%20reviews.%20Genetics&rft.au=Folstein,%20S%20E&rft.date=2001-12&rft.volume=2&rft.issue=12&rft.spage=943&rft.epage=955&rft.pages=943-955&rft.issn=1471-0056&rft.eissn=1471-0064&rft_id=info:doi/10.1038/35103559&rft_dat=%3Cproquest_pubme%3E72323937%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=223753696&rft_id=info:pmid/11733747&rfr_iscdi=true |