Serum Eosinophil Cationic Protein in Active and Quiescent Ulcerative Colitis
Inflammatory bowel disorders are characterized by an accumulation of eosinophilic granulocytes, mast cells, lymphocytes and neutrophilic granulocytes in the intestinal mucosa. The aim of this study was to examine the concentration of eosinophilic granulocytes in the blood of patients during active u...
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| Veröffentlicht in: | Clinical chemistry and laboratory medicine 2000-07, Vol.38 (7), p.619-622 |
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| creator | Pronk-Admiraal, Claudia J. Linskens, Ronald K. Bodegraven, Ad A. Van Tuynman, Hans A.R.E. Bartels, Piet C.M. |
| description | Inflammatory bowel disorders are characterized by an accumulation of eosinophilic granulocytes, mast cells, lymphocytes and neutrophilic granulocytes in the intestinal mucosa. The aim of this study was to examine the concentration of eosinophilic granulocytes in the blood of patients during active ulcerative colitis in comparison with patients during remission and apparently healthy control subjects. Besides counting, the activity grade of eosinophilic granulocytes has been studied by estimation of their degranulation product eosinophil cationic protein. Subjects with active ulcerative colitis could be distinguished from patients with quiescent ulcerative colitis by establishment of the eosinophil cationic protein concentration, neutrophilic granulocyte count, erythrocyte sedimentation rate, C-reactive protein and albumin concentration. After two weeks of corticosteroid treatment, serum eosinophil cationic protein concentrations and eosinophil counts in blood were significantly decreased. A decrease in blood eosinophil count was accompanied by a decrease in eosinophil cationic protein concentrations in serum in most subjects with ulcerative colitis. After twelve weeks of corticosteroid administration, serum albumin concentrations were significantly increased, whereas serum concentrations of C-reactive protein were significantly decreased. During treatment with corticosteroids, serum eosinophil cationic protein concentrations and blood eosinophil counts are appropriate laboratory markers to detect the effect of medication in the course of ulcerative colitis. |
| doi_str_mv | 10.1515/CCLM.2000.090 |
| format | Article |
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Van ; Tuynman, Hans A.R.E. ; Bartels, Piet C.M.</creator><creatorcontrib>Pronk-Admiraal, Claudia J. ; Linskens, Ronald K. ; Bodegraven, Ad A. Van ; Tuynman, Hans A.R.E. ; Bartels, Piet C.M.</creatorcontrib><description>Inflammatory bowel disorders are characterized by an accumulation of eosinophilic granulocytes, mast cells, lymphocytes and neutrophilic granulocytes in the intestinal mucosa. The aim of this study was to examine the concentration of eosinophilic granulocytes in the blood of patients during active ulcerative colitis in comparison with patients during remission and apparently healthy control subjects. Besides counting, the activity grade of eosinophilic granulocytes has been studied by estimation of their degranulation product eosinophil cationic protein. Subjects with active ulcerative colitis could be distinguished from patients with quiescent ulcerative colitis by establishment of the eosinophil cationic protein concentration, neutrophilic granulocyte count, erythrocyte sedimentation rate, C-reactive protein and albumin concentration. After two weeks of corticosteroid treatment, serum eosinophil cationic protein concentrations and eosinophil counts in blood were significantly decreased. A decrease in blood eosinophil count was accompanied by a decrease in eosinophil cationic protein concentrations in serum in most subjects with ulcerative colitis. After twelve weeks of corticosteroid administration, serum albumin concentrations were significantly increased, whereas serum concentrations of C-reactive protein were significantly decreased. During treatment with corticosteroids, serum eosinophil cationic protein concentrations and blood eosinophil counts are appropriate laboratory markers to detect the effect of medication in the course of ulcerative colitis.</description><identifier>ISSN: 1434-6621</identifier><identifier>EISSN: 1437-4331</identifier><identifier>DOI: 10.1515/CCLM.2000.090</identifier><identifier>PMID: 11028767</identifier><language>eng</language><publisher>Berlin: Walter de Gruyter</publisher><subject>Adrenal Cortex Hormones - therapeutic use ; Adult ; Aged ; Analysis of Variance ; Anti-Inflammatory Agents - therapeutic use ; Biological and medical sciences ; Blood Proteins - analysis ; Blood Sedimentation ; C-Reactive Protein - analysis ; Colitis, Ulcerative - blood ; Colitis, Ulcerative - drug therapy ; Colitis, Ulcerative - physiopathology ; Digestive system ; Eosinophil Granule Proteins ; Eosinophils ; Female ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Leukocyte Count ; Male ; Medical sciences ; Middle Aged ; Pathology. 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Van</creatorcontrib><creatorcontrib>Tuynman, Hans A.R.E.</creatorcontrib><creatorcontrib>Bartels, Piet C.M.</creatorcontrib><title>Serum Eosinophil Cationic Protein in Active and Quiescent Ulcerative Colitis</title><title>Clinical chemistry and laboratory medicine</title><addtitle>Clinical Chemistry and Laboratory Medicine</addtitle><description>Inflammatory bowel disorders are characterized by an accumulation of eosinophilic granulocytes, mast cells, lymphocytes and neutrophilic granulocytes in the intestinal mucosa. The aim of this study was to examine the concentration of eosinophilic granulocytes in the blood of patients during active ulcerative colitis in comparison with patients during remission and apparently healthy control subjects. Besides counting, the activity grade of eosinophilic granulocytes has been studied by estimation of their degranulation product eosinophil cationic protein. Subjects with active ulcerative colitis could be distinguished from patients with quiescent ulcerative colitis by establishment of the eosinophil cationic protein concentration, neutrophilic granulocyte count, erythrocyte sedimentation rate, C-reactive protein and albumin concentration. After two weeks of corticosteroid treatment, serum eosinophil cationic protein concentrations and eosinophil counts in blood were significantly decreased. A decrease in blood eosinophil count was accompanied by a decrease in eosinophil cationic protein concentrations in serum in most subjects with ulcerative colitis. After twelve weeks of corticosteroid administration, serum albumin concentrations were significantly increased, whereas serum concentrations of C-reactive protein were significantly decreased. During treatment with corticosteroids, serum eosinophil cationic protein concentrations and blood eosinophil counts are appropriate laboratory markers to detect the effect of medication in the course of ulcerative colitis.</description><subject>Adrenal Cortex Hormones - therapeutic use</subject><subject>Adult</subject><subject>Aged</subject><subject>Analysis of Variance</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Blood Proteins - analysis</subject><subject>Blood Sedimentation</subject><subject>C-Reactive Protein - analysis</subject><subject>Colitis, Ulcerative - blood</subject><subject>Colitis, Ulcerative - drug therapy</subject><subject>Colitis, Ulcerative - physiopathology</subject><subject>Digestive system</subject><subject>Eosinophil Granule Proteins</subject><subject>Eosinophils</subject><subject>Female</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Leukocyte Count</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pathology. 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Miscellaneous investigative techniques</subject><subject>Predictive Value of Tests</subject><subject>Ribonucleases</subject><subject>Serum Albumin - analysis</subject><subject>Steroids</subject><issn>1434-6621</issn><issn>1437-4331</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtLxDAQh4Morq-jVykI3rpOkubRoxRfuOJrXbyFbJpgtNuuSSv639tdl_UoDMzAfPxm-BA6xDDEDLPTohjdDgkADCGHDbSDMyrSjFK8uZyzlHOCB2g3xjcAzFgmttEAYyBScLGDRk82dLPkvIm-buavvkoK3fqm9ia5D01rfZ30dWZa_2kTXZfJQ-dtNLZuk-fK2KCXi6KpfOvjPtpyuor2YNX30PjifFxcpaO7y-vibJQaKnmbEm1BSpdTcKKcEpeDdMIwaQw4Iq00Uzwtc0kxN9gRLYkTDoxxkDNe0ozuoZPf2HloPjobWzXz_UtVpWvbdFEJQgmlWf4vSIBJ3mvowfQXNKGJMVin5sHPdPhWGNRCs1poVgvNqtfc80er4G46s-UfvfLaA8crQEejKxd0bXxccxI4w_zvrI-t_VpvdXhXfYZg6mGcqRu4fcknjxN1T38Ay3GTfA</recordid><startdate>20000711</startdate><enddate>20000711</enddate><creator>Pronk-Admiraal, Claudia J.</creator><creator>Linskens, Ronald K.</creator><creator>Bodegraven, Ad A. Van</creator><creator>Tuynman, Hans A.R.E.</creator><creator>Bartels, Piet C.M.</creator><general>Walter de Gruyter</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20000711</creationdate><title>Serum Eosinophil Cationic Protein in Active and Quiescent Ulcerative Colitis</title><author>Pronk-Admiraal, Claudia J. ; Linskens, Ronald K. ; Bodegraven, Ad A. 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Besides counting, the activity grade of eosinophilic granulocytes has been studied by estimation of their degranulation product eosinophil cationic protein. Subjects with active ulcerative colitis could be distinguished from patients with quiescent ulcerative colitis by establishment of the eosinophil cationic protein concentration, neutrophilic granulocyte count, erythrocyte sedimentation rate, C-reactive protein and albumin concentration. After two weeks of corticosteroid treatment, serum eosinophil cationic protein concentrations and eosinophil counts in blood were significantly decreased. A decrease in blood eosinophil count was accompanied by a decrease in eosinophil cationic protein concentrations in serum in most subjects with ulcerative colitis. After twelve weeks of corticosteroid administration, serum albumin concentrations were significantly increased, whereas serum concentrations of C-reactive protein were significantly decreased. 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| subjects | Adrenal Cortex Hormones - therapeutic use Adult Aged Analysis of Variance Anti-Inflammatory Agents - therapeutic use Biological and medical sciences Blood Proteins - analysis Blood Sedimentation C-Reactive Protein - analysis Colitis, Ulcerative - blood Colitis, Ulcerative - drug therapy Colitis, Ulcerative - physiopathology Digestive system Eosinophil Granule Proteins Eosinophils Female Humans Investigative techniques, diagnostic techniques (general aspects) Leukocyte Count Male Medical sciences Middle Aged Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Predictive Value of Tests Ribonucleases Serum Albumin - analysis Steroids |
| title | Serum Eosinophil Cationic Protein in Active and Quiescent Ulcerative Colitis |
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