The cytotoxicity of chronic neuroinflammation upon basal forebrain cholinergic neurons of rats can be attenuated by glutamatergic antagonism or cyclooxygenase-2 inhibition

The proinflammagen lipopolysaccharide (LPS) was infused chronically (37 days) into the basal forebrain of rats. The current study determined whether the chronic administration of either a non-competitive N-methyl-D-aspartate- (NMDA-) sensitive receptor antagonist, memantine, or a selective cyclooxyg...

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Veröffentlicht in:	Experimental brain research 2000-09, Vol.134 (1), p.58-65
Hauptverfasser:	WILLARD, L. B, HAUSS-WEGRZYNIAK, B, DANYSZ, W, WENK, G. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - metabolism Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Biological and medical sciences Cholinergic Fibers - chemistry Cholinergic Fibers - drug effects Cholinergic Fibers - enzymology Chronic Disease cyclooxygenase 1 Cyclooxygenase 2 Encephalitis - drug therapy Encephalitis - enzymology Encephalitis - physiopathology Excitatory Amino Acid Antagonists - pharmacology Glutamic Acid - metabolism Image Cytometry - methods Isoenzymes - antagonists & inhibitors Isoenzymes - metabolism Male Medical sciences Memantine - pharmacology Nerve Tissue Proteins - analysis Neuropharmacology Neuroprotective agent Pharmacology. Drug treatments Phenols - pharmacology Prosencephalon - cytology Prosencephalon - enzymology Prosencephalon - immunology Prostaglandin-Endoperoxide Synthases - metabolism Radioimmunoassay Rats Rats, Inbred F344 Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Thiazoles - pharmacology
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