Electrophysiological effects of sustained delivery of CRF and its receptor agonists in hippocampal slices
The corticotropin-releasing factor (CRF) is a hypothalamic peptide that regulates the release of adrenocorticotropic hormone (ATCH) and of β-endorphin. It has been suggested that it modulates learning and memory processes in rat. However, the electrophysiological effects that CRF produces on hippoca...
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| Veröffentlicht in: | Brain research 2001-12, Vol.922 (1), p.112-117 |
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| creator | Rebaudo, Renata Melani, Raffaella Balestrino, Maurizio Izvarina, Natalia |
| description | The corticotropin-releasing factor (CRF) is a hypothalamic peptide that regulates the release of adrenocorticotropic hormone (ATCH) and of β-endorphin. It has been suggested that it modulates learning and memory processes in rat. However, the electrophysiological effects that CRF produces on hippocampal neurons have been so far little investigated. In particular, the effects of CRF on long-term potentiation (LTP), a phenomenon which is thought to be the substrate of memory processes, are unknown. We studied the effects of sustained administration of CRF and of two of its receptor agonists on basal neuronal activity and on in vitro hippocampal LTP. The two receptor agonists were
d-Glu-20-CRF and
d-Pro-5-CRF, selective for the CRF-R1 and the CRF-R2 receptors, respectively. We found that CRF,
d-Pro-5-CRF and
d-Glu-20-CRF at the concentration of 1 nM diminish the amplitude of hippocampal population spike and prevent the onset of LTP. Higher concentrations of CFR have less depressing effects on neuronal activity, yet they still prevent the occurrence of LTP. |
| doi_str_mv | 10.1016/S0006-8993(01)03160-2 |
| format | Article |
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d-Glu-20-CRF and
d-Pro-5-CRF, selective for the CRF-R1 and the CRF-R2 receptors, respectively. We found that CRF,
d-Pro-5-CRF and
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d-Glu-20-CRF and
d-Pro-5-CRF, selective for the CRF-R1 and the CRF-R2 receptors, respectively. We found that CRF,
d-Pro-5-CRF and
d-Glu-20-CRF at the concentration of 1 nM diminish the amplitude of hippocampal population spike and prevent the onset of LTP. Higher concentrations of CFR have less depressing effects on neuronal activity, yet they still prevent the occurrence of LTP.</description><subject>Action Potentials - drug effects</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>Corticotropin-releasing factor</subject><subject>Corticotropin-Releasing Hormone - administration & dosage</subject><subject>Corticotropin-Releasing Hormone - analogs & derivatives</subject><subject>Corticotropin-Releasing Hormone - pharmacology</subject><subject>Electrophysiology</subject><subject>Female</subject><subject>firing pattern</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hippocampus</subject><subject>Hippocampus - drug effects</subject><subject>In Vitro Techniques</subject><subject>Long-term potentiation</subject><subject>Long-Term Potentiation - drug effects</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Corticotropin-Releasing Hormone - agonists</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9v1DAQxS0EokvhI4ByAcEhMGMncXKq0KoFpEpI_Dlb3smkNcrGwZOttN8eb3dFj9UcrHn6zYz1nlKvET4iYPPpJwA0Zdt15j3gBzDYQKmfqBW2VpeNruCpWv1HztQLkT-5NaaD5-oM0Rqw0K5UuByZlhTn272EOMabQH4seBiyKkUcCtnJ4sPEfdHzGO447Q_q-sdV4ae-CBlKTDwvMRX-Jk5BshKm4jbMcyS_nfM2GQOxvFTPBj8Kvzq95-r31eWv9dfy-vuXb-vP1yVVWi-l5s3QYYcNWiRvwdcNEhqEusWWrSWqmGq76duh3xDpijsYsCZfa23YkDlX74575xT_7lgWtw1CPI5-4rgTZ7XJZbtHQWw1QteaDNZHkFIUSTy4OYWtT3uH4A5huPsw3MFpB-juw3A6z705Hdhtttw_TJ3cz8DbE-Al2z4kP1GQB65CU1V1lbmLI8fZt7vAyQkFnoj7kM1fXB_DI1_5B6W_pyI</recordid><startdate>20011213</startdate><enddate>20011213</enddate><creator>Rebaudo, Renata</creator><creator>Melani, Raffaella</creator><creator>Balestrino, Maurizio</creator><creator>Izvarina, Natalia</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20011213</creationdate><title>Electrophysiological effects of sustained delivery of CRF and its receptor agonists in hippocampal slices</title><author>Rebaudo, Renata ; Melani, Raffaella ; Balestrino, Maurizio ; Izvarina, Natalia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-2ebf91916171ca70a561c13105818e77cc4ec57bd8fdbcc24e90f15ca5223e3c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Action Potentials - drug effects</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Corticotropin-releasing factor</topic><topic>Corticotropin-Releasing Hormone - administration & dosage</topic><topic>Corticotropin-Releasing Hormone - analogs & derivatives</topic><topic>Corticotropin-Releasing Hormone - pharmacology</topic><topic>Electrophysiology</topic><topic>Female</topic><topic>firing pattern</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hippocampus</topic><topic>Hippocampus - drug effects</topic><topic>In Vitro Techniques</topic><topic>Long-term potentiation</topic><topic>Long-Term Potentiation - drug effects</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Corticotropin-Releasing Hormone - agonists</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rebaudo, Renata</creatorcontrib><creatorcontrib>Melani, Raffaella</creatorcontrib><creatorcontrib>Balestrino, Maurizio</creatorcontrib><creatorcontrib>Izvarina, Natalia</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rebaudo, Renata</au><au>Melani, Raffaella</au><au>Balestrino, Maurizio</au><au>Izvarina, Natalia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Electrophysiological effects of sustained delivery of CRF and its receptor agonists in hippocampal slices</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>2001-12-13</date><risdate>2001</risdate><volume>922</volume><issue>1</issue><spage>112</spage><epage>117</epage><pages>112-117</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>The corticotropin-releasing factor (CRF) is a hypothalamic peptide that regulates the release of adrenocorticotropic hormone (ATCH) and of β-endorphin. It has been suggested that it modulates learning and memory processes in rat. However, the electrophysiological effects that CRF produces on hippocampal neurons have been so far little investigated. In particular, the effects of CRF on long-term potentiation (LTP), a phenomenon which is thought to be the substrate of memory processes, are unknown. We studied the effects of sustained administration of CRF and of two of its receptor agonists on basal neuronal activity and on in vitro hippocampal LTP. The two receptor agonists were
d-Glu-20-CRF and
d-Pro-5-CRF, selective for the CRF-R1 and the CRF-R2 receptors, respectively. We found that CRF,
d-Pro-5-CRF and
d-Glu-20-CRF at the concentration of 1 nM diminish the amplitude of hippocampal population spike and prevent the onset of LTP. Higher concentrations of CFR have less depressing effects on neuronal activity, yet they still prevent the occurrence of LTP.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>11730708</pmid><doi>10.1016/S0006-8993(01)03160-2</doi><tpages>6</tpages></addata></record> |
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| subjects | Action Potentials - drug effects Animals Biological and medical sciences Central nervous system Corticotropin-releasing factor Corticotropin-Releasing Hormone - administration & dosage Corticotropin-Releasing Hormone - analogs & derivatives Corticotropin-Releasing Hormone - pharmacology Electrophysiology Female firing pattern Fundamental and applied biological sciences. Psychology Hippocampus Hippocampus - drug effects In Vitro Techniques Long-term potentiation Long-Term Potentiation - drug effects Rats Rats, Sprague-Dawley Receptors, Corticotropin-Releasing Hormone - agonists Vertebrates: nervous system and sense organs |
| title | Electrophysiological effects of sustained delivery of CRF and its receptor agonists in hippocampal slices |
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