Forebrain-Specific Calcineurin Knockout Selectively Impairs Bidirectional Synaptic Plasticity and Working/Episodic-like Memory

Calcineurin is a calcium-dependent protein phosphatase that has been implicated in various aspects of synaptic plasticity. By using conditional gene-targeting techniques, we created mice in which calcineurin activity is disrupted specifically in the adult forebrain. At hippocampal Schaffer collatera...

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Veröffentlicht in:	Cell 2001-11, Vol.107 (5), p.617-629
Hauptverfasser:	Zeng, Hongkui, Chattarji, Sumantra, Barbarosie, Michaela, Rondi-Reig, Laure, Philpot, Benjamin D., Miyakawa, Tsuyoshi, Bear, Mark F., Tonegawa, Susumu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcineurin - genetics Calcineurin - metabolism Conditioning (Psychology) - physiology Excitatory Postsynaptic Potentials - physiology Gene Targeting Hippocampus - cytology Hippocampus - physiology In Situ Hybridization In Vitro Techniques Learning - physiology Male Maze Learning - physiology Memory - physiology Mice Mice, Inbred C57BL Mice, Knockout Neuronal Plasticity - physiology Patch-Clamp Techniques Protein Isoforms Protein Subunits Receptors, N-Methyl-D-Aspartate - metabolism
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