Remodeling of Synaptic Actin Induced by Photoconductive Stimulation
Use-dependent synapse remodeling is thought to provide a cellular mechanism for encoding durable memories, yet whether activity triggers an actual structural change has remained controversial. We use photoconductive stimulation to demonstrate activity-dependent morphological synaptic plasticity by v...
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| Veröffentlicht in: | Cell 2001-11, Vol.107 (5), p.605-616 |
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| creator | Colicos, Michael A. Collins, Boyce E. Sailor, Michael J. Goda, Yukiko |
| description | Use-dependent synapse remodeling is thought to provide a cellular mechanism for encoding durable memories, yet whether activity triggers an actual structural change has remained controversial. We use photoconductive stimulation to demonstrate activity-dependent morphological synaptic plasticity by video imaging of GFP-actin at individual synapses. A single tetanus transiently moves presynaptic actin toward and postsynaptic actin away from the synaptic junction. Repetitive spaced tetani induce glutamate receptor-dependent stable restructuring of synapses. Presynaptic actin redistributes and forms new puncta that label for an active synapse marker FM5-95 within 2 hr. Postsynaptic actin sprouts projections toward the new presynaptic actin puncta, resembling the axon-dendrite interaction during synaptogenesis. Our results indicate that activity-dependent presynaptic structural plasticity facilitates the formation of new active presynaptic terminals. |
| doi_str_mv | 10.1016/S0092-8674(01)00579-7 |
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We use photoconductive stimulation to demonstrate activity-dependent morphological synaptic plasticity by video imaging of GFP-actin at individual synapses. A single tetanus transiently moves presynaptic actin toward and postsynaptic actin away from the synaptic junction. Repetitive spaced tetani induce glutamate receptor-dependent stable restructuring of synapses. Presynaptic actin redistributes and forms new puncta that label for an active synapse marker FM5-95 within 2 hr. Postsynaptic actin sprouts projections toward the new presynaptic actin puncta, resembling the axon-dendrite interaction during synaptogenesis. Our results indicate that activity-dependent presynaptic structural plasticity facilitates the formation of new active presynaptic terminals.</description><identifier>ISSN: 0092-8674</identifier><identifier>EISSN: 1097-4172</identifier><identifier>DOI: 10.1016/S0092-8674(01)00579-7</identifier><identifier>PMID: 11733060</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology ; Actins - metabolism ; Aniline Compounds - metabolism ; Animals ; Calcium - metabolism ; Cells, Cultured ; Cyclic AMP - analogs & derivatives ; Cyclic AMP - metabolism ; Cyclic AMP - pharmacology ; Electric Stimulation ; Enzyme Inhibitors - pharmacology ; Excitatory Amino Acid Antagonists - pharmacology ; Fluorescent Dyes - metabolism ; Genes, Reporter ; Green Fluorescent Proteins ; Hippocampus - cytology ; Light ; Luminescent Proteins - genetics ; Luminescent Proteins - metabolism ; Microscopy, Video ; Neuronal Plasticity - physiology ; Neurons - drug effects ; Neurons - metabolism ; Rats ; Receptors, N-Methyl-D-Aspartate - metabolism ; Recombinant Fusion Proteins - metabolism ; Signal Transduction ; Silicon - chemistry ; Synapses - metabolism ; Thionucleotides - pharmacology ; Valine - analogs & derivatives ; Valine - pharmacology ; Xanthenes - metabolism</subject><ispartof>Cell, 2001-11, Vol.107 (5), p.605-616</ispartof><rights>2001 Cell Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c557t-b4293a5424f30aef4bc3a46b5b617b5d80832848b83e667f52f27ee419470b353</citedby><cites>FETCH-LOGICAL-c557t-b4293a5424f30aef4bc3a46b5b617b5d80832848b83e667f52f27ee419470b353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0092-8674(01)00579-7$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11733060$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Colicos, Michael A.</creatorcontrib><creatorcontrib>Collins, Boyce E.</creatorcontrib><creatorcontrib>Sailor, Michael J.</creatorcontrib><creatorcontrib>Goda, Yukiko</creatorcontrib><title>Remodeling of Synaptic Actin Induced by Photoconductive Stimulation</title><title>Cell</title><addtitle>Cell</addtitle><description>Use-dependent synapse remodeling is thought to provide a cellular mechanism for encoding durable memories, yet whether activity triggers an actual structural change has remained controversial. We use photoconductive stimulation to demonstrate activity-dependent morphological synaptic plasticity by video imaging of GFP-actin at individual synapses. A single tetanus transiently moves presynaptic actin toward and postsynaptic actin away from the synaptic junction. Repetitive spaced tetani induce glutamate receptor-dependent stable restructuring of synapses. Presynaptic actin redistributes and forms new puncta that label for an active synapse marker FM5-95 within 2 hr. Postsynaptic actin sprouts projections toward the new presynaptic actin puncta, resembling the axon-dendrite interaction during synaptogenesis. Our results indicate that activity-dependent presynaptic structural plasticity facilitates the formation of new active presynaptic terminals.</description><subject>6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology</subject><subject>Actins - metabolism</subject><subject>Aniline Compounds - metabolism</subject><subject>Animals</subject><subject>Calcium - metabolism</subject><subject>Cells, Cultured</subject><subject>Cyclic AMP - analogs & derivatives</subject><subject>Cyclic AMP - metabolism</subject><subject>Cyclic AMP - pharmacology</subject><subject>Electric Stimulation</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Excitatory Amino Acid Antagonists - pharmacology</subject><subject>Fluorescent Dyes - metabolism</subject><subject>Genes, Reporter</subject><subject>Green Fluorescent Proteins</subject><subject>Hippocampus - cytology</subject><subject>Light</subject><subject>Luminescent Proteins - genetics</subject><subject>Luminescent Proteins - metabolism</subject><subject>Microscopy, Video</subject><subject>Neuronal Plasticity - physiology</subject><subject>Neurons - drug effects</subject><subject>Neurons - metabolism</subject><subject>Rats</subject><subject>Receptors, N-Methyl-D-Aspartate - metabolism</subject><subject>Recombinant Fusion Proteins - metabolism</subject><subject>Signal Transduction</subject><subject>Silicon - chemistry</subject><subject>Synapses - metabolism</subject><subject>Thionucleotides - pharmacology</subject><subject>Valine - analogs & derivatives</subject><subject>Valine - pharmacology</subject><subject>Xanthenes - metabolism</subject><issn>0092-8674</issn><issn>1097-4172</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLxDAUhYMoOj5-gtKV6KJ682ralQyDLxhQHF2HJr3VSNuMTSrMv3de6NLVhct3zoGPkFMKVxRodj0DKFiaZ0pcAL0EkKpI1Q4ZUShUKqhiu2T0ixyQwxA-ASCXUu6TA0oV55DBiExesPUVNq57T3ydzBZdOY_OJmMbXZc8dtVgsUrMInn-8NFbv3pE943JLLp2aMrofHdM9uqyCXiyvUfk7e72dfKQTp_uHyfjaWqlVDE1ghW8lIKJmkOJtTCWlyIz0mRUGVnlkHOWi9zkHLNM1ZLVTCEKWggFhkt-RM43vfPefw0Yom5dsNg0ZYd-CFoxzihI8S9Ic6aA0xUoN6DtfQg91nreu7bsF5qCXmnWa8165VAD1WvNWi1zZ9uBwbRY_aW2XpfAzQbApY9vh70O1mG3dOl6tFFX3v0z8QNKMotI</recordid><startdate>20011130</startdate><enddate>20011130</enddate><creator>Colicos, Michael A.</creator><creator>Collins, Boyce E.</creator><creator>Sailor, Michael J.</creator><creator>Goda, Yukiko</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20011130</creationdate><title>Remodeling of Synaptic Actin Induced by Photoconductive Stimulation</title><author>Colicos, Michael A. ; Collins, Boyce E. ; Sailor, Michael J. ; Goda, Yukiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c557t-b4293a5424f30aef4bc3a46b5b617b5d80832848b83e667f52f27ee419470b353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology</topic><topic>Actins - metabolism</topic><topic>Aniline Compounds - metabolism</topic><topic>Animals</topic><topic>Calcium - metabolism</topic><topic>Cells, Cultured</topic><topic>Cyclic AMP - analogs & derivatives</topic><topic>Cyclic AMP - metabolism</topic><topic>Cyclic AMP - pharmacology</topic><topic>Electric Stimulation</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Excitatory Amino Acid Antagonists - pharmacology</topic><topic>Fluorescent Dyes - metabolism</topic><topic>Genes, Reporter</topic><topic>Green Fluorescent Proteins</topic><topic>Hippocampus - cytology</topic><topic>Light</topic><topic>Luminescent Proteins - genetics</topic><topic>Luminescent Proteins - metabolism</topic><topic>Microscopy, Video</topic><topic>Neuronal Plasticity - physiology</topic><topic>Neurons - drug effects</topic><topic>Neurons - metabolism</topic><topic>Rats</topic><topic>Receptors, N-Methyl-D-Aspartate - metabolism</topic><topic>Recombinant Fusion Proteins - metabolism</topic><topic>Signal Transduction</topic><topic>Silicon - chemistry</topic><topic>Synapses - metabolism</topic><topic>Thionucleotides - pharmacology</topic><topic>Valine - analogs & derivatives</topic><topic>Valine - pharmacology</topic><topic>Xanthenes - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Colicos, Michael A.</creatorcontrib><creatorcontrib>Collins, Boyce E.</creatorcontrib><creatorcontrib>Sailor, Michael J.</creatorcontrib><creatorcontrib>Goda, Yukiko</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Colicos, Michael A.</au><au>Collins, Boyce E.</au><au>Sailor, Michael J.</au><au>Goda, Yukiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Remodeling of Synaptic Actin Induced by Photoconductive Stimulation</atitle><jtitle>Cell</jtitle><addtitle>Cell</addtitle><date>2001-11-30</date><risdate>2001</risdate><volume>107</volume><issue>5</issue><spage>605</spage><epage>616</epage><pages>605-616</pages><issn>0092-8674</issn><eissn>1097-4172</eissn><abstract>Use-dependent synapse remodeling is thought to provide a cellular mechanism for encoding durable memories, yet whether activity triggers an actual structural change has remained controversial. We use photoconductive stimulation to demonstrate activity-dependent morphological synaptic plasticity by video imaging of GFP-actin at individual synapses. A single tetanus transiently moves presynaptic actin toward and postsynaptic actin away from the synaptic junction. Repetitive spaced tetani induce glutamate receptor-dependent stable restructuring of synapses. Presynaptic actin redistributes and forms new puncta that label for an active synapse marker FM5-95 within 2 hr. Postsynaptic actin sprouts projections toward the new presynaptic actin puncta, resembling the axon-dendrite interaction during synaptogenesis. Our results indicate that activity-dependent presynaptic structural plasticity facilitates the formation of new active presynaptic terminals.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>11733060</pmid><doi>10.1016/S0092-8674(01)00579-7</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology Actins - metabolism Aniline Compounds - metabolism Animals Calcium - metabolism Cells, Cultured Cyclic AMP - analogs & derivatives Cyclic AMP - metabolism Cyclic AMP - pharmacology Electric Stimulation Enzyme Inhibitors - pharmacology Excitatory Amino Acid Antagonists - pharmacology Fluorescent Dyes - metabolism Genes, Reporter Green Fluorescent Proteins Hippocampus - cytology Light Luminescent Proteins - genetics Luminescent Proteins - metabolism Microscopy, Video Neuronal Plasticity - physiology Neurons - drug effects Neurons - metabolism Rats Receptors, N-Methyl-D-Aspartate - metabolism Recombinant Fusion Proteins - metabolism Signal Transduction Silicon - chemistry Synapses - metabolism Thionucleotides - pharmacology Valine - analogs & derivatives Valine - pharmacology Xanthenes - metabolism |
| title | Remodeling of Synaptic Actin Induced by Photoconductive Stimulation |
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