The SMN genes are subject to transcriptional regulation during cellular differentiation

Proximal spinal muscular atrophy (SMA) is an autosomal recessive disease characterized by degeneration of α-motor neurons and muscular atrophy. The causal survival motor neuron ( SMN) gene maps to a complex region of chromosome 5q13 harbouring an inverted duplication. Thus, there are two SMN genes,...

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Veröffentlicht in:	Gene 2001-11, Vol.279 (2), p.109-117
Hauptverfasser:	Germain-Desprez, Delphine, Brun, Thierry, Rochette, Camille, Semionov, Alexandre, Rouget, Raphael, Simard, Louise R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Binding Sites - genetics Cell Differentiation - genetics Chloramphenicol O-Acetyltransferase - genetics Chloramphenicol O-Acetyltransferase - metabolism chromosome 5 Core promoter Cyclic AMP Response Element-Binding Protein DNA - genetics Female Gene Expression Regulation - drug effects Humans Mice Molecular Sequence Data Muscular Atrophy, Spinal - genetics Nerve Tissue Proteins - genetics Promoter Regions, Genetic - genetics Recombinant Fusion Proteins - drug effects Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism RNA-Binding Proteins Sequence Homology, Nucleic Acid SMN Complex Proteins SMN1 gene SMN2 gene spinal muscular atrophy Survival of Motor Neuron 1 Protein Survival of Motor Neuron 2 Protein Transcription Factors - metabolism Transcription initiation Transcription Initiation Site Transcription, Genetic Tretinoin - pharmacology Tumor Cells, Cultured
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