Response of leptin mRNA to 24-h food deprivation and refeeding is influenced by age in rats
To obtain an insight into the influence of aging on leptin gene expression, the responses of leptin mRNA in retroperitoneal and epididymal adipose tissues and plasma leptin concentrations to 24-h food deprivation and refeeding were examined in 2-, 10- and 24-month-old normal rats. The basal level of...
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| Veröffentlicht in: | Regulatory peptides 2000-08, Vol.92 (1), p.45-50 |
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| creator | Ishii, Shinya Shibasaki, Tamotsu Murakami, Takashi Shima, Kenji Wakabayashi, Ichiji |
| description | To obtain an insight into the influence of aging on leptin gene expression, the responses of leptin mRNA in retroperitoneal and epididymal adipose tissues and plasma leptin concentrations to 24-h food deprivation and refeeding were examined in 2-, 10- and 24-month-old normal rats. The basal level of leptin gene expression in retroperitoneal adipose tissue was significantly higher in 10- and 24-month-old rats than that in 2-month-old rats, while the level in epididymal adipose tissue was highest in 10-month-old rats for all three age groups. The basal concentrations of plasma leptin was significantly higher in 10- and 24-month-old rats than those in 2-month-old rats. The 24-h food deprivation was followed by a significant reduction in leptin mRNA expression in both retorperitoneal and epididymal adipose tissues for all three age groups. The leptin gene expression was restored to control levels 24 h following refeeding in the 2- and 10-month-old rats, but failed to be restored in the 24-month-old rats. In addition, the time course of recovery for leptin mRNA expression by refeeding to the control levels differed between the retroperitoneal and the epididymal adipose tissue in 2- and 10-month-old rats. The concentrations of plasma leptin 24 h following refeeding were compatible with the leptin mRNA levels in adipose tissues in three age groups. These results suggest that the expression of the leptin gene in response to food-deprivation and refeeding is influenced by an animal’s age and that this expression is different for different regions of white adipose tissue. |
| doi_str_mv | 10.1016/S0167-0115(00)00148-8 |
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The basal level of leptin gene expression in retroperitoneal adipose tissue was significantly higher in 10- and 24-month-old rats than that in 2-month-old rats, while the level in epididymal adipose tissue was highest in 10-month-old rats for all three age groups. The basal concentrations of plasma leptin was significantly higher in 10- and 24-month-old rats than those in 2-month-old rats. The 24-h food deprivation was followed by a significant reduction in leptin mRNA expression in both retorperitoneal and epididymal adipose tissues for all three age groups. The leptin gene expression was restored to control levels 24 h following refeeding in the 2- and 10-month-old rats, but failed to be restored in the 24-month-old rats. In addition, the time course of recovery for leptin mRNA expression by refeeding to the control levels differed between the retroperitoneal and the epididymal adipose tissue in 2- and 10-month-old rats. The concentrations of plasma leptin 24 h following refeeding were compatible with the leptin mRNA levels in adipose tissues in three age groups. These results suggest that the expression of the leptin gene in response to food-deprivation and refeeding is influenced by an animal’s age and that this expression is different for different regions of white adipose tissue.</description><identifier>ISSN: 0167-0115</identifier><identifier>EISSN: 1873-1686</identifier><identifier>DOI: 10.1016/S0167-0115(00)00148-8</identifier><identifier>PMID: 11024564</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adipose tissue ; Adipose Tissue - metabolism ; Aging - metabolism ; Animals ; Body Weight ; Eating ; Food Deprivation ; Gene Expression ; Leptin - genetics ; Male ; Obese gene ; Organ Size ; Rats ; Rats, Wistar ; RNA, Messenger ; Time Factors</subject><ispartof>Regulatory peptides, 2000-08, Vol.92 (1), p.45-50</ispartof><rights>2000 Elsevier Science B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-eec36dcf2dd819843adfa4e2ca1f258820a4ffd68107aeb44e787c82f0cd04243</citedby><cites>FETCH-LOGICAL-c427t-eec36dcf2dd819843adfa4e2ca1f258820a4ffd68107aeb44e787c82f0cd04243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0167-0115(00)00148-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11024564$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ishii, Shinya</creatorcontrib><creatorcontrib>Shibasaki, Tamotsu</creatorcontrib><creatorcontrib>Murakami, Takashi</creatorcontrib><creatorcontrib>Shima, Kenji</creatorcontrib><creatorcontrib>Wakabayashi, Ichiji</creatorcontrib><title>Response of leptin mRNA to 24-h food deprivation and refeeding is influenced by age in rats</title><title>Regulatory peptides</title><addtitle>Regul Pept</addtitle><description>To obtain an insight into the influence of aging on leptin gene expression, the responses of leptin mRNA in retroperitoneal and epididymal adipose tissues and plasma leptin concentrations to 24-h food deprivation and refeeding were examined in 2-, 10- and 24-month-old normal rats. The basal level of leptin gene expression in retroperitoneal adipose tissue was significantly higher in 10- and 24-month-old rats than that in 2-month-old rats, while the level in epididymal adipose tissue was highest in 10-month-old rats for all three age groups. The basal concentrations of plasma leptin was significantly higher in 10- and 24-month-old rats than those in 2-month-old rats. The 24-h food deprivation was followed by a significant reduction in leptin mRNA expression in both retorperitoneal and epididymal adipose tissues for all three age groups. The leptin gene expression was restored to control levels 24 h following refeeding in the 2- and 10-month-old rats, but failed to be restored in the 24-month-old rats. In addition, the time course of recovery for leptin mRNA expression by refeeding to the control levels differed between the retroperitoneal and the epididymal adipose tissue in 2- and 10-month-old rats. The concentrations of plasma leptin 24 h following refeeding were compatible with the leptin mRNA levels in adipose tissues in three age groups. These results suggest that the expression of the leptin gene in response to food-deprivation and refeeding is influenced by an animal’s age and that this expression is different for different regions of white adipose tissue.</description><subject>Adipose tissue</subject><subject>Adipose Tissue - metabolism</subject><subject>Aging - metabolism</subject><subject>Animals</subject><subject>Body Weight</subject><subject>Eating</subject><subject>Food Deprivation</subject><subject>Gene Expression</subject><subject>Leptin - genetics</subject><subject>Male</subject><subject>Obese gene</subject><subject>Organ Size</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>RNA, Messenger</subject><subject>Time Factors</subject><issn>0167-0115</issn><issn>1873-1686</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMo7rr6E5ScRA_VJE2beJJl8QsWhVVPHkI2mayRtqlNu7D_3u4HevQyA8MzM7wPQqeUXFFC8-vXvoiEUJpdEHJJCOUykXtoSKVIE5rLfB8Nf5EBOorxq4cyIdJDNKCUMJ7lfIg-ZhDrUEXAweEC6tZXuJw9j3EbMOPJJ3YhWGyhbvxStz5UWFcWN-AArK8W2EfsK1d0UBmweL7CegH9BDe6jcfowOkiwsmuj9D7_d3b5DGZvjw8TcbTxHAm2gTApLk1jlkr6Y3kqbZOc2BGU8cyKRnR3DmbS0qEhjnnIKQwkjliLOGMpyN0vr1bN-G7g9iq0kcDRaErCF1UgqWMiGwNZlvQNCHGPoTqY5W6WSlK1Nqq2lhVa2WKELWxqmS_d7Z70M1LsH9bO409cLsFoI-59NCoaPxGiW_AtMoG_8-LH8RFhl8</recordid><startdate>20000825</startdate><enddate>20000825</enddate><creator>Ishii, Shinya</creator><creator>Shibasaki, Tamotsu</creator><creator>Murakami, Takashi</creator><creator>Shima, Kenji</creator><creator>Wakabayashi, Ichiji</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000825</creationdate><title>Response of leptin mRNA to 24-h food deprivation and refeeding is influenced by age in rats</title><author>Ishii, Shinya ; Shibasaki, Tamotsu ; Murakami, Takashi ; Shima, Kenji ; Wakabayashi, Ichiji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-eec36dcf2dd819843adfa4e2ca1f258820a4ffd68107aeb44e787c82f0cd04243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adipose tissue</topic><topic>Adipose Tissue - metabolism</topic><topic>Aging - metabolism</topic><topic>Animals</topic><topic>Body Weight</topic><topic>Eating</topic><topic>Food Deprivation</topic><topic>Gene Expression</topic><topic>Leptin - genetics</topic><topic>Male</topic><topic>Obese gene</topic><topic>Organ Size</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>RNA, Messenger</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ishii, Shinya</creatorcontrib><creatorcontrib>Shibasaki, Tamotsu</creatorcontrib><creatorcontrib>Murakami, Takashi</creatorcontrib><creatorcontrib>Shima, Kenji</creatorcontrib><creatorcontrib>Wakabayashi, Ichiji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Regulatory peptides</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ishii, Shinya</au><au>Shibasaki, Tamotsu</au><au>Murakami, Takashi</au><au>Shima, Kenji</au><au>Wakabayashi, Ichiji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Response of leptin mRNA to 24-h food deprivation and refeeding is influenced by age in rats</atitle><jtitle>Regulatory peptides</jtitle><addtitle>Regul Pept</addtitle><date>2000-08-25</date><risdate>2000</risdate><volume>92</volume><issue>1</issue><spage>45</spage><epage>50</epage><pages>45-50</pages><issn>0167-0115</issn><eissn>1873-1686</eissn><abstract>To obtain an insight into the influence of aging on leptin gene expression, the responses of leptin mRNA in retroperitoneal and epididymal adipose tissues and plasma leptin concentrations to 24-h food deprivation and refeeding were examined in 2-, 10- and 24-month-old normal rats. The basal level of leptin gene expression in retroperitoneal adipose tissue was significantly higher in 10- and 24-month-old rats than that in 2-month-old rats, while the level in epididymal adipose tissue was highest in 10-month-old rats for all three age groups. The basal concentrations of plasma leptin was significantly higher in 10- and 24-month-old rats than those in 2-month-old rats. The 24-h food deprivation was followed by a significant reduction in leptin mRNA expression in both retorperitoneal and epididymal adipose tissues for all three age groups. The leptin gene expression was restored to control levels 24 h following refeeding in the 2- and 10-month-old rats, but failed to be restored in the 24-month-old rats. In addition, the time course of recovery for leptin mRNA expression by refeeding to the control levels differed between the retroperitoneal and the epididymal adipose tissue in 2- and 10-month-old rats. The concentrations of plasma leptin 24 h following refeeding were compatible with the leptin mRNA levels in adipose tissues in three age groups. These results suggest that the expression of the leptin gene in response to food-deprivation and refeeding is influenced by an animal’s age and that this expression is different for different regions of white adipose tissue.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>11024564</pmid><doi>10.1016/S0167-0115(00)00148-8</doi><tpages>6</tpages></addata></record> |
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| subjects | Adipose tissue Adipose Tissue - metabolism Aging - metabolism Animals Body Weight Eating Food Deprivation Gene Expression Leptin - genetics Male Obese gene Organ Size Rats Rats, Wistar RNA, Messenger Time Factors |
| title | Response of leptin mRNA to 24-h food deprivation and refeeding is influenced by age in rats |
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