Microchip technology in drug delivery
The realization that the therapeutic efficacy of certain drugs can be affected dramatically by the way in which they are delivered has created immense interest in controlled drug delivery systems. Much previous work in drug delivery focused on achieving sustained drug release rates over time, while...
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| Veröffentlicht in: | Annals of medicine (Helsinki) 2000, Vol.32 (6), p.377-379 |
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| container_end_page | 379 |
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| container_issue | 6 |
| container_start_page | 377 |
| container_title | Annals of medicine (Helsinki) |
| container_volume | 32 |
| creator | Santini, John T Richards, Amy C Scheidt, Rebecca A Cima, Michael J Langer, Robert S |
| description | The realization that the therapeutic efficacy of certain drugs can be affected dramatically by the way in which they are delivered has created immense interest in controlled drug delivery systems. Much previous work in drug delivery focused on achieving sustained drug release rates over time, while a more recent trend is to make devices that allow the release rate to be varied over time. Advances in microfabrication technology have made an entirely new type of drug delivery device possible. Proof-of-principle experiments have shown that silicon microchips have the ability to store and release multiple chemicals on demand. Future integration of active control electronics, such as microprocessors, remote control units, or biosensors, could lead to the development of a 'pharmacy on a chip,' ie 'smart' microchip implants or tablets that release drugs into the body automatically when needed. |
| doi_str_mv | 10.3109/07853890008995941 |
| format | Article |
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Much previous work in drug delivery focused on achieving sustained drug release rates over time, while a more recent trend is to make devices that allow the release rate to be varied over time. Advances in microfabrication technology have made an entirely new type of drug delivery device possible. Proof-of-principle experiments have shown that silicon microchips have the ability to store and release multiple chemicals on demand. Future integration of active control electronics, such as microprocessors, remote control units, or biosensors, could lead to the development of a 'pharmacy on a chip,' ie 'smart' microchip implants or tablets that release drugs into the body automatically when needed.</description><subject>Biological and medical sciences</subject><subject>Biomedical Engineering</subject><subject>controlled release</subject><subject>Delayed-Action Preparations</subject><subject>dosage forms</subject><subject>drug administration routes</subject><subject>drug delivery systems</subject><subject>Drug Delivery Systems - instrumentation</subject><subject>Drug Implants</subject><subject>drug therapy</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>microchemistry</subject><subject>microchip</subject><subject>Miniaturization</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>pharmacy on a chip</subject><subject>Silicon</subject><subject>Tablets</subject><subject>Technology, Pharmaceutical</subject><issn>0785-3890</issn><issn>1365-2060</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMoun78AC-yB_VWnSRNk6AXWfwCxYueS5pOd7tkmzVplf33tuyKiOBpDvM8wzsvIccULjgFfQlSCa40ACithU7pFhlRnomEQQbbZDTskwHYI_sxznuOSQq7ZI9SYCpTbETOnmsbvJ3Vy3GLdtZ456ercd2My9BNxyW6-gPD6pDsVMZFPNrMA_J2d_s6eUieXu4fJzdPiU1l2iYFYEozVlSyKiphM2EEloUskIJkqUi1tKrUCFYAG3KiLYELJTW1FAur-QE5X99dBv_eYWzzRR0tOmca9F3MJeMMOOU9SNdgHz7GgFW-DPXChFVOIR-6yf900zsnm-NdscDyx9iU0QOnG8BEa1wVTGPr-MOlSigYQl6vsbqpfFiYTx9cmbdm5Xz4dvh_Ma5-6TM0rp1ZEzCf-y40fb__PPEFiF2Phg</recordid><startdate>2000</startdate><enddate>2000</enddate><creator>Santini, John T</creator><creator>Richards, Amy C</creator><creator>Scheidt, Rebecca A</creator><creator>Cima, Michael J</creator><creator>Langer, Robert S</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2000</creationdate><title>Microchip technology in drug delivery</title><author>Santini, John T ; Richards, Amy C ; Scheidt, Rebecca A ; Cima, Michael J ; Langer, Robert S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-b0e4162bf7fbf5c65a5edb7be107245497c8d9e0c5021365ecd0358791c1ebc93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Biological and medical sciences</topic><topic>Biomedical Engineering</topic><topic>controlled release</topic><topic>Delayed-Action Preparations</topic><topic>dosage forms</topic><topic>drug administration routes</topic><topic>drug delivery systems</topic><topic>Drug Delivery Systems - instrumentation</topic><topic>Drug Implants</topic><topic>drug therapy</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>microchemistry</topic><topic>microchip</topic><topic>Miniaturization</topic><topic>Pharmaceutical technology. 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| fulltext | fulltext |
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| ispartof | Annals of medicine (Helsinki), 2000, Vol.32 (6), p.377-379 |
| issn | 0785-3890 1365-2060 |
| language | eng |
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| source | MEDLINE; Access via Taylor & Francis; EZB-FREE-00999 freely available EZB journals |
| subjects | Biological and medical sciences Biomedical Engineering controlled release Delayed-Action Preparations dosage forms drug administration routes drug delivery systems Drug Delivery Systems - instrumentation Drug Implants drug therapy General pharmacology Humans Medical sciences microchemistry microchip Miniaturization Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments pharmacy on a chip Silicon Tablets Technology, Pharmaceutical |
| title | Microchip technology in drug delivery |
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