Safety of Adeno-Associated Virus as Cochlear Gene Transfer Vector: Analysis of Distant Spread Beyond Injected Cochleae

The adeno-associated virus (AAV), inoculated into the perilymph, has been shown to be an effective vector for mediating intracochlear transgene expression. The unexpected finding of transgene expression in the contralateral cochlea in previous work raised concern about dissemination of the virus fro...

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Veröffentlicht in:	Molecular therapy 2000-10, Vol.2 (4), p.368-373
Hauptverfasser:	Kho, Soochuen T., Pettis, Robert M., Mhatre, Anand N., Lalwani, Anil K.
Format:	Artikel
Sprache:	eng
Schlagworte:	adeno-associated virus Animals beta-Galactosidase - genetics beta-Galactosidase - metabolism Blotting, Western Bone marrow Bone Marrow - virology Cell division Cerebellum - virology Cochlea - virology cochlear gene therapy Dependovirus - genetics DNA Primers - chemistry DNA, Viral - analysis Ears & hearing Gene expression Gene therapy Gene Transfer Techniques Genetic testing Genetic Therapy Genetic Vectors Guinea Pigs Heart Immunohistochemistry Laboratory animals Liver Male Microscopy, Fluorescence Otology Polymerase Chain Reaction Proteins Proto-Oncogene Proteins c-myc - metabolism Safety Spleen Surgery viral dissemination
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