Malignancy in HIV/AIDs: A single hospital experience
Background and Objectives Our hospital serves an area with a significant number of patients seropositive for the human immunodeficiency virus (HIV). Intravenous drug abuse and heterosexual exposure are by far the predominant risk factors for HIV and acquired immunodeficiency syndrome (AIDS). Seven p...
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| Veröffentlicht in: | Journal of surgical oncology 2000-09, Vol.75 (1), p.11-18 |
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| container_title | Journal of surgical oncology |
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| creator | Albu, Eugene Reed, Mary Pathak, Ranganath Niazi, Masooma Sivakumar, Mahalingam Fernandes, Eugene Mailapur, Ravindra V. Parithivel, Vellore S. Gerst, Paul H. |
| description | Background and Objectives
Our hospital serves an area with a significant number of patients seropositive for the human immunodeficiency virus (HIV). Intravenous drug abuse and heterosexual exposure are by far the predominant risk factors for HIV and acquired immunodeficiency syndrome (AIDS). Seven percent of these patients develop malignancies. Our aim was to study the types of tumor, their distribution, and to evaluate the patients' outcome.
Methods
Of 3,578 patients with HIV infection or AIDS treated between 1993 and 1998, 245 had 1 or more malignancies. Information was collected on age, sex, race, predisposing risk factors for AIDS, malignancies, symptoms at presentation, the time of the onset of AIDS, CD4 cell counts, pathology findings, and mortality.
Results
Although aspects of our patients resembled those of previously studied groups of patients with AIDS, there also were ways in which our patients differed from those other groups. Of our patients, 21.6% had non‐AIDS‐defining (NAD) invasive malignancies. This was considerably higher than the rate in most studies. Twenty‐seven patients with such malignancies died during the study. Forty‐two other patients had pre‐invasive cancers. Among patients having AIDS‐defining (AD) malignancies, 55.9% died, a fact that was related to patients' low CD4 cell counts and late presentation. Our 97 patients with Kaposi sarcoma included 22 women, a relatively high number that may be related to the fact that most of our patients were intravenous drug abusers or had become infected by heterosexual transmission of HIV.
Conclusions
AIDS is associated with a high risk of malignancy and an unusual spectrum of tumors. Patients with invasive tumors have advanced disease at the time of initial presentation. Those with AD tumors have a worse prognosis than patients with NAD tumors. The impact of highly active antiretroviral therapy on both AD and NAD tumors needs to be further evaluated. J. Surg. Oncol. 2000;75:11–18. © 2000 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/1096-9098(200009)75:1<11::AID-JSO3>3.0.CO;2-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72319564</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72319564</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3963-853df195636226f9d69a6e29a1bc97ab15008e473fa7c7878ffc6d3e62b132883</originalsourceid><addsrcrecordid>eNqNkE1vEzEQQC0EoqHwF9AeEILDpjP22l4HhBQF2galDRIf5TZyHG9x2WzCOhHNv8fLRu2FA75Ylt48248xiTBEAH6CYFRuwJSvOKRlXms5wreIo9F4-j7_-Hku3okhDCfzNzyHB2xwxz9kgzTP80IbOGJPYrzpxo0qHrMjROCykGrAigtbh-vGNm6fhSY7n347Sd44ysZZDM117bMf67gJW1tn_nbj2-Ab55-yR5Wto3922I_Z19MPXybn-Wx-Np2MZ7kTRom8lGJZoZFKKM5VZZbKWOW5sbhwRtsFSoDSF1pUVjtd6rKqnFoKr_gCBS9Lccxe9t5Nu_6183FLqxCdr2vb-PUukuai0xcJvOhB165jbH1FmzasbLsnBOoyUpeFuizUZyQtCQmRKH2XuowkCGgyJ06QfM8PF-8WK7-8tx26JeDFAbDR2bpqU8AQ7zkJQkKHXfbY71D7_f8_6h9v-ntOwrwXhrj1t3dC2_4kpUUav7o8o-KUz9T3K6RP4g-6J6H4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72319564</pqid></control><display><type>article</type><title>Malignancy in HIV/AIDs: A single hospital experience</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Albu, Eugene ; Reed, Mary ; Pathak, Ranganath ; Niazi, Masooma ; Sivakumar, Mahalingam ; Fernandes, Eugene ; Mailapur, Ravindra V. ; Parithivel, Vellore S. ; Gerst, Paul H.</creator><creatorcontrib>Albu, Eugene ; Reed, Mary ; Pathak, Ranganath ; Niazi, Masooma ; Sivakumar, Mahalingam ; Fernandes, Eugene ; Mailapur, Ravindra V. ; Parithivel, Vellore S. ; Gerst, Paul H.</creatorcontrib><description>Background and Objectives
Our hospital serves an area with a significant number of patients seropositive for the human immunodeficiency virus (HIV). Intravenous drug abuse and heterosexual exposure are by far the predominant risk factors for HIV and acquired immunodeficiency syndrome (AIDS). Seven percent of these patients develop malignancies. Our aim was to study the types of tumor, their distribution, and to evaluate the patients' outcome.
Methods
Of 3,578 patients with HIV infection or AIDS treated between 1993 and 1998, 245 had 1 or more malignancies. Information was collected on age, sex, race, predisposing risk factors for AIDS, malignancies, symptoms at presentation, the time of the onset of AIDS, CD4 cell counts, pathology findings, and mortality.
Results
Although aspects of our patients resembled those of previously studied groups of patients with AIDS, there also were ways in which our patients differed from those other groups. Of our patients, 21.6% had non‐AIDS‐defining (NAD) invasive malignancies. This was considerably higher than the rate in most studies. Twenty‐seven patients with such malignancies died during the study. Forty‐two other patients had pre‐invasive cancers. Among patients having AIDS‐defining (AD) malignancies, 55.9% died, a fact that was related to patients' low CD4 cell counts and late presentation. Our 97 patients with Kaposi sarcoma included 22 women, a relatively high number that may be related to the fact that most of our patients were intravenous drug abusers or had become infected by heterosexual transmission of HIV.
Conclusions
AIDS is associated with a high risk of malignancy and an unusual spectrum of tumors. Patients with invasive tumors have advanced disease at the time of initial presentation. Those with AD tumors have a worse prognosis than patients with NAD tumors. The impact of highly active antiretroviral therapy on both AD and NAD tumors needs to be further evaluated. J. Surg. Oncol. 2000;75:11–18. © 2000 Wiley‐Liss, Inc.</description><identifier>ISSN: 0022-4790</identifier><identifier>EISSN: 1096-9098</identifier><identifier>DOI: 10.1002/1096-9098(200009)75:1<11::AID-JSO3>3.0.CO;2-0</identifier><identifier>PMID: 11025456</identifier><identifier>CODEN: JSONAU</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Acquired Immunodeficiency Syndrome - complications ; Adolescent ; Adult ; Aged ; AIDS ; AIDS-Related Complex - etiology ; AIDS/HIV ; Biological and medical sciences ; Carcinoma in Situ - etiology ; CD4 Lymphocyte Count ; Child ; Child, Preschool ; Female ; General aspects ; HIV Infections - complications ; Homosexuality ; Human viral diseases ; Humans ; Infectious diseases ; Lung Neoplasms - etiology ; Lymphoma, AIDS-Related - etiology ; Male ; malignancy ; Medical sciences ; Middle Aged ; Risk Factors ; Sarcoma, Kaposi - etiology ; Skin Neoplasms - etiology ; Tumors ; Uterine Cervical Neoplasms - etiology ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids</subject><ispartof>Journal of surgical oncology, 2000-09, Vol.75 (1), p.11-18</ispartof><rights>Copyright © 2000 Wiley‐Liss, Inc.</rights><rights>2000 INIST-CNRS</rights><rights>Copyright 2000 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3963-853df195636226f9d69a6e29a1bc97ab15008e473fa7c7878ffc6d3e62b132883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F1096-9098%28200009%2975%3A1%3C11%3A%3AAID-JSO3%3E3.0.CO%3B2-0$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F1096-9098%28200009%2975%3A1%3C11%3A%3AAID-JSO3%3E3.0.CO%3B2-0$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1503506$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11025456$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Albu, Eugene</creatorcontrib><creatorcontrib>Reed, Mary</creatorcontrib><creatorcontrib>Pathak, Ranganath</creatorcontrib><creatorcontrib>Niazi, Masooma</creatorcontrib><creatorcontrib>Sivakumar, Mahalingam</creatorcontrib><creatorcontrib>Fernandes, Eugene</creatorcontrib><creatorcontrib>Mailapur, Ravindra V.</creatorcontrib><creatorcontrib>Parithivel, Vellore S.</creatorcontrib><creatorcontrib>Gerst, Paul H.</creatorcontrib><title>Malignancy in HIV/AIDs: A single hospital experience</title><title>Journal of surgical oncology</title><addtitle>J. Surg. Oncol</addtitle><description>Background and Objectives
Our hospital serves an area with a significant number of patients seropositive for the human immunodeficiency virus (HIV). Intravenous drug abuse and heterosexual exposure are by far the predominant risk factors for HIV and acquired immunodeficiency syndrome (AIDS). Seven percent of these patients develop malignancies. Our aim was to study the types of tumor, their distribution, and to evaluate the patients' outcome.
Methods
Of 3,578 patients with HIV infection or AIDS treated between 1993 and 1998, 245 had 1 or more malignancies. Information was collected on age, sex, race, predisposing risk factors for AIDS, malignancies, symptoms at presentation, the time of the onset of AIDS, CD4 cell counts, pathology findings, and mortality.
Results
Although aspects of our patients resembled those of previously studied groups of patients with AIDS, there also were ways in which our patients differed from those other groups. Of our patients, 21.6% had non‐AIDS‐defining (NAD) invasive malignancies. This was considerably higher than the rate in most studies. Twenty‐seven patients with such malignancies died during the study. Forty‐two other patients had pre‐invasive cancers. Among patients having AIDS‐defining (AD) malignancies, 55.9% died, a fact that was related to patients' low CD4 cell counts and late presentation. Our 97 patients with Kaposi sarcoma included 22 women, a relatively high number that may be related to the fact that most of our patients were intravenous drug abusers or had become infected by heterosexual transmission of HIV.
Conclusions
AIDS is associated with a high risk of malignancy and an unusual spectrum of tumors. Patients with invasive tumors have advanced disease at the time of initial presentation. Those with AD tumors have a worse prognosis than patients with NAD tumors. The impact of highly active antiretroviral therapy on both AD and NAD tumors needs to be further evaluated. J. Surg. Oncol. 2000;75:11–18. © 2000 Wiley‐Liss, Inc.</description><subject>Acquired Immunodeficiency Syndrome - complications</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>AIDS</subject><subject>AIDS-Related Complex - etiology</subject><subject>AIDS/HIV</subject><subject>Biological and medical sciences</subject><subject>Carcinoma in Situ - etiology</subject><subject>CD4 Lymphocyte Count</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>General aspects</subject><subject>HIV Infections - complications</subject><subject>Homosexuality</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Lung Neoplasms - etiology</subject><subject>Lymphoma, AIDS-Related - etiology</subject><subject>Male</subject><subject>malignancy</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Risk Factors</subject><subject>Sarcoma, Kaposi - etiology</subject><subject>Skin Neoplasms - etiology</subject><subject>Tumors</subject><subject>Uterine Cervical Neoplasms - etiology</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><issn>0022-4790</issn><issn>1096-9098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1vEzEQQC0EoqHwF9AeEILDpjP22l4HhBQF2galDRIf5TZyHG9x2WzCOhHNv8fLRu2FA75Ylt48248xiTBEAH6CYFRuwJSvOKRlXms5wreIo9F4-j7_-Hku3okhDCfzNzyHB2xwxz9kgzTP80IbOGJPYrzpxo0qHrMjROCykGrAigtbh-vGNm6fhSY7n347Sd44ysZZDM117bMf67gJW1tn_nbj2-Ab55-yR5Wto3922I_Z19MPXybn-Wx-Np2MZ7kTRom8lGJZoZFKKM5VZZbKWOW5sbhwRtsFSoDSF1pUVjtd6rKqnFoKr_gCBS9Lccxe9t5Nu_6183FLqxCdr2vb-PUukuai0xcJvOhB165jbH1FmzasbLsnBOoyUpeFuizUZyQtCQmRKH2XuowkCGgyJ06QfM8PF-8WK7-8tx26JeDFAbDR2bpqU8AQ7zkJQkKHXfbY71D7_f8_6h9v-ntOwrwXhrj1t3dC2_4kpUUav7o8o-KUz9T3K6RP4g-6J6H4</recordid><startdate>200009</startdate><enddate>200009</enddate><creator>Albu, Eugene</creator><creator>Reed, Mary</creator><creator>Pathak, Ranganath</creator><creator>Niazi, Masooma</creator><creator>Sivakumar, Mahalingam</creator><creator>Fernandes, Eugene</creator><creator>Mailapur, Ravindra V.</creator><creator>Parithivel, Vellore S.</creator><creator>Gerst, Paul H.</creator><general>John Wiley & Sons, Inc</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200009</creationdate><title>Malignancy in HIV/AIDs: A single hospital experience</title><author>Albu, Eugene ; Reed, Mary ; Pathak, Ranganath ; Niazi, Masooma ; Sivakumar, Mahalingam ; Fernandes, Eugene ; Mailapur, Ravindra V. ; Parithivel, Vellore S. ; Gerst, Paul H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3963-853df195636226f9d69a6e29a1bc97ab15008e473fa7c7878ffc6d3e62b132883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Acquired Immunodeficiency Syndrome - complications</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>AIDS</topic><topic>AIDS-Related Complex - etiology</topic><topic>AIDS/HIV</topic><topic>Biological and medical sciences</topic><topic>Carcinoma in Situ - etiology</topic><topic>CD4 Lymphocyte Count</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>General aspects</topic><topic>HIV Infections - complications</topic><topic>Homosexuality</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Lung Neoplasms - etiology</topic><topic>Lymphoma, AIDS-Related - etiology</topic><topic>Male</topic><topic>malignancy</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Risk Factors</topic><topic>Sarcoma, Kaposi - etiology</topic><topic>Skin Neoplasms - etiology</topic><topic>Tumors</topic><topic>Uterine Cervical Neoplasms - etiology</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Albu, Eugene</creatorcontrib><creatorcontrib>Reed, Mary</creatorcontrib><creatorcontrib>Pathak, Ranganath</creatorcontrib><creatorcontrib>Niazi, Masooma</creatorcontrib><creatorcontrib>Sivakumar, Mahalingam</creatorcontrib><creatorcontrib>Fernandes, Eugene</creatorcontrib><creatorcontrib>Mailapur, Ravindra V.</creatorcontrib><creatorcontrib>Parithivel, Vellore S.</creatorcontrib><creatorcontrib>Gerst, Paul H.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Albu, Eugene</au><au>Reed, Mary</au><au>Pathak, Ranganath</au><au>Niazi, Masooma</au><au>Sivakumar, Mahalingam</au><au>Fernandes, Eugene</au><au>Mailapur, Ravindra V.</au><au>Parithivel, Vellore S.</au><au>Gerst, Paul H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Malignancy in HIV/AIDs: A single hospital experience</atitle><jtitle>Journal of surgical oncology</jtitle><addtitle>J. Surg. Oncol</addtitle><date>2000-09</date><risdate>2000</risdate><volume>75</volume><issue>1</issue><spage>11</spage><epage>18</epage><pages>11-18</pages><issn>0022-4790</issn><eissn>1096-9098</eissn><coden>JSONAU</coden><abstract>Background and Objectives
Our hospital serves an area with a significant number of patients seropositive for the human immunodeficiency virus (HIV). Intravenous drug abuse and heterosexual exposure are by far the predominant risk factors for HIV and acquired immunodeficiency syndrome (AIDS). Seven percent of these patients develop malignancies. Our aim was to study the types of tumor, their distribution, and to evaluate the patients' outcome.
Methods
Of 3,578 patients with HIV infection or AIDS treated between 1993 and 1998, 245 had 1 or more malignancies. Information was collected on age, sex, race, predisposing risk factors for AIDS, malignancies, symptoms at presentation, the time of the onset of AIDS, CD4 cell counts, pathology findings, and mortality.
Results
Although aspects of our patients resembled those of previously studied groups of patients with AIDS, there also were ways in which our patients differed from those other groups. Of our patients, 21.6% had non‐AIDS‐defining (NAD) invasive malignancies. This was considerably higher than the rate in most studies. Twenty‐seven patients with such malignancies died during the study. Forty‐two other patients had pre‐invasive cancers. Among patients having AIDS‐defining (AD) malignancies, 55.9% died, a fact that was related to patients' low CD4 cell counts and late presentation. Our 97 patients with Kaposi sarcoma included 22 women, a relatively high number that may be related to the fact that most of our patients were intravenous drug abusers or had become infected by heterosexual transmission of HIV.
Conclusions
AIDS is associated with a high risk of malignancy and an unusual spectrum of tumors. Patients with invasive tumors have advanced disease at the time of initial presentation. Those with AD tumors have a worse prognosis than patients with NAD tumors. The impact of highly active antiretroviral therapy on both AD and NAD tumors needs to be further evaluated. J. Surg. Oncol. 2000;75:11–18. © 2000 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>11025456</pmid><doi>10.1002/1096-9098(200009)75:1<11::AID-JSO3>3.0.CO;2-0</doi><tpages>8</tpages></addata></record> |
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| subjects | Acquired Immunodeficiency Syndrome - complications Adolescent Adult Aged AIDS AIDS-Related Complex - etiology AIDS/HIV Biological and medical sciences Carcinoma in Situ - etiology CD4 Lymphocyte Count Child Child, Preschool Female General aspects HIV Infections - complications Homosexuality Human viral diseases Humans Infectious diseases Lung Neoplasms - etiology Lymphoma, AIDS-Related - etiology Male malignancy Medical sciences Middle Aged Risk Factors Sarcoma, Kaposi - etiology Skin Neoplasms - etiology Tumors Uterine Cervical Neoplasms - etiology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
| title | Malignancy in HIV/AIDs: A single hospital experience |
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