Riluzole suppresses post-sigh, but not spontaneous apnoeas during sleep in rats

We conducted this experiment to determine the role of glutamate in the mechanism of sleep apnoeas by administering riluzole, a glutamate release inhibitor, to freely moving rats in which sleep‐related apnoeas are physiological phenomena. Adult Sprague‐Dawley rats were implanted with electrodes for e...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 2001-11, Vol.53 (11), p.1555-1559
Hauptverfasser:	Radulovacki, Miodrag, Pavlovic, Sasa, Rakic, Andrei, Janelidze, Marika, Shermulis, Lisa, Carley, David W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dose-Response Relationship, Drug Excitatory Amino Acid Antagonists - pharmacology Excitatory Amino Acid Antagonists - therapeutic use Male Rats Rats, Sprague-Dawley Receptors, Glutamate - drug effects Receptors, Glutamate - physiology Riluzole - pharmacology Riluzole - therapeutic use Sleep Apnea Syndromes - drug therapy Sleep Apnea Syndromes - physiopathology Sleep, REM - drug effects Wakefulness - drug effects
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