Riluzole suppresses post-sigh, but not spontaneous apnoeas during sleep in rats
We conducted this experiment to determine the role of glutamate in the mechanism of sleep apnoeas by administering riluzole, a glutamate release inhibitor, to freely moving rats in which sleep‐related apnoeas are physiological phenomena. Adult Sprague‐Dawley rats were implanted with electrodes for e...
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| Veröffentlicht in: | Journal of pharmacy and pharmacology 2001-11, Vol.53 (11), p.1555-1559 |
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| container_title | Journal of pharmacy and pharmacology |
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| creator | Radulovacki, Miodrag Pavlovic, Sasa Rakic, Andrei Janelidze, Marika Shermulis, Lisa Carley, David W. |
| description | We conducted this experiment to determine the role of glutamate in the mechanism of sleep apnoeas by administering riluzole, a glutamate release inhibitor, to freely moving rats in which sleep‐related apnoeas are physiological phenomena. Adult Sprague‐Dawley rats were implanted with electrodes for electroencephalogram (EEG) and electromyogram (EMG) recording to monitor sleep and were placed inside a single‐chamber plethysmograph to monitor respiration. Sleep and respiration were recorded for 6 h following intraperitoneal administration of 0.5, 5.0 and 10.0 mg kg−1 riluzole. Riluzole dose‐dependently suppressed post‐sigh apnoeas during rapid eye movement (REM) sleep but had no effect on sleep‐related spontaneous apnoeas. The drug (5.0 and 10.0 mg kg−1) also dose‐dependently reduced wakefulness and increased sleep. It appears that glutamate, an excitatory neurotransmitter, plays a role in the genesis of the post‐sigh apnoeas during REM sleep. |
| doi_str_mv | 10.1211/0022357011777936 |
| format | Article |
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Adult Sprague‐Dawley rats were implanted with electrodes for electroencephalogram (EEG) and electromyogram (EMG) recording to monitor sleep and were placed inside a single‐chamber plethysmograph to monitor respiration. Sleep and respiration were recorded for 6 h following intraperitoneal administration of 0.5, 5.0 and 10.0 mg kg−1 riluzole. Riluzole dose‐dependently suppressed post‐sigh apnoeas during rapid eye movement (REM) sleep but had no effect on sleep‐related spontaneous apnoeas. The drug (5.0 and 10.0 mg kg−1) also dose‐dependently reduced wakefulness and increased sleep. It appears that glutamate, an excitatory neurotransmitter, plays a role in the genesis of the post‐sigh apnoeas during REM sleep.</description><identifier>ISSN: 0022-3573</identifier><identifier>EISSN: 2042-7158</identifier><identifier>DOI: 10.1211/0022357011777936</identifier><identifier>PMID: 11732759</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Dose-Response Relationship, Drug ; Excitatory Amino Acid Antagonists - pharmacology ; Excitatory Amino Acid Antagonists - therapeutic use ; Male ; Rats ; Rats, Sprague-Dawley ; Receptors, Glutamate - drug effects ; Receptors, Glutamate - physiology ; Riluzole - pharmacology ; Riluzole - therapeutic use ; Sleep Apnea Syndromes - drug therapy ; Sleep Apnea Syndromes - physiopathology ; Sleep, REM - drug effects ; Wakefulness - drug effects</subject><ispartof>Journal of pharmacy and pharmacology, 2001-11, Vol.53 (11), p.1555-1559</ispartof><rights>2001 Royal Pharmaceutical Society of Great Britain</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4222-6feffa087c39e26633e5d5e4d1b46cd30de68209fca806102934ba6b24b1b75d3</citedby><cites>FETCH-LOGICAL-c4222-6feffa087c39e26633e5d5e4d1b46cd30de68209fca806102934ba6b24b1b75d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1211%2F0022357011777936$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1211%2F0022357011777936$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11732759$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Radulovacki, Miodrag</creatorcontrib><creatorcontrib>Pavlovic, Sasa</creatorcontrib><creatorcontrib>Rakic, Andrei</creatorcontrib><creatorcontrib>Janelidze, Marika</creatorcontrib><creatorcontrib>Shermulis, Lisa</creatorcontrib><creatorcontrib>Carley, David W.</creatorcontrib><title>Riluzole suppresses post-sigh, but not spontaneous apnoeas during sleep in rats</title><title>Journal of pharmacy and pharmacology</title><addtitle>J Pharm Pharmacol</addtitle><description>We conducted this experiment to determine the role of glutamate in the mechanism of sleep apnoeas by administering riluzole, a glutamate release inhibitor, to freely moving rats in which sleep‐related apnoeas are physiological phenomena. Adult Sprague‐Dawley rats were implanted with electrodes for electroencephalogram (EEG) and electromyogram (EMG) recording to monitor sleep and were placed inside a single‐chamber plethysmograph to monitor respiration. Sleep and respiration were recorded for 6 h following intraperitoneal administration of 0.5, 5.0 and 10.0 mg kg−1 riluzole. Riluzole dose‐dependently suppressed post‐sigh apnoeas during rapid eye movement (REM) sleep but had no effect on sleep‐related spontaneous apnoeas. The drug (5.0 and 10.0 mg kg−1) also dose‐dependently reduced wakefulness and increased sleep. It appears that glutamate, an excitatory neurotransmitter, plays a role in the genesis of the post‐sigh apnoeas during REM sleep.</description><subject>Animals</subject><subject>Dose-Response Relationship, Drug</subject><subject>Excitatory Amino Acid Antagonists - pharmacology</subject><subject>Excitatory Amino Acid Antagonists - therapeutic use</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Glutamate - drug effects</subject><subject>Receptors, Glutamate - physiology</subject><subject>Riluzole - pharmacology</subject><subject>Riluzole - therapeutic use</subject><subject>Sleep Apnea Syndromes - drug therapy</subject><subject>Sleep Apnea Syndromes - physiopathology</subject><subject>Sleep, REM - drug effects</subject><subject>Wakefulness - drug effects</subject><issn>0022-3573</issn><issn>2042-7158</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDlPw0AQhVcIRMLRU6GtqDDs5d24RBEkoAABcZSrtT0OBsc2O7Y4fj1GjkCioZrifd_T6BGyx9kRF5wfMyaEDA3j3BgTSb1GhoIpERgejtbJ8DsOulwOyBbiM2PMaK03yaDjpTBhNCTXt3nRflYFUGzr2gMiIK0rbALMF0-HNG4bWlYNxboqG1dC1SJ1dVmBQ5q2Pi8XFAuAmuYl9a7BHbKRuQJhd3W3yf3Z6d14GsyuJ-fjk1mQKNE9pTPIMsdGJpERCK2lhDANQaU8VjpJJUtBjwSLssSNmOZMRFLFTsdCxTw2YSq3yUHfW_vqtQVs7DLHBIqi_9EaIXnEFe9A1oOJrxA9ZLb2-dL5D8uZ_R7R_h2xU_ZX3W28hPRXWK3WAboH3vICPv4ttBfz6ZwrLTox6MUcG3j_EZ1_sdpIE9rHq4kd34zVw3x6ay_lFxnkizc</recordid><startdate>200111</startdate><enddate>200111</enddate><creator>Radulovacki, Miodrag</creator><creator>Pavlovic, Sasa</creator><creator>Rakic, Andrei</creator><creator>Janelidze, Marika</creator><creator>Shermulis, Lisa</creator><creator>Carley, David W.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200111</creationdate><title>Riluzole suppresses post-sigh, but not spontaneous apnoeas during sleep in rats</title><author>Radulovacki, Miodrag ; Pavlovic, Sasa ; Rakic, Andrei ; Janelidze, Marika ; Shermulis, Lisa ; Carley, David W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4222-6feffa087c39e26633e5d5e4d1b46cd30de68209fca806102934ba6b24b1b75d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Dose-Response Relationship, Drug</topic><topic>Excitatory Amino Acid Antagonists - pharmacology</topic><topic>Excitatory Amino Acid Antagonists - therapeutic use</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Glutamate - drug effects</topic><topic>Receptors, Glutamate - physiology</topic><topic>Riluzole - pharmacology</topic><topic>Riluzole - therapeutic use</topic><topic>Sleep Apnea Syndromes - drug therapy</topic><topic>Sleep Apnea Syndromes - physiopathology</topic><topic>Sleep, REM - drug effects</topic><topic>Wakefulness - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Radulovacki, Miodrag</creatorcontrib><creatorcontrib>Pavlovic, Sasa</creatorcontrib><creatorcontrib>Rakic, Andrei</creatorcontrib><creatorcontrib>Janelidze, Marika</creatorcontrib><creatorcontrib>Shermulis, Lisa</creatorcontrib><creatorcontrib>Carley, David W.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmacy and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Radulovacki, Miodrag</au><au>Pavlovic, Sasa</au><au>Rakic, Andrei</au><au>Janelidze, Marika</au><au>Shermulis, Lisa</au><au>Carley, David W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Riluzole suppresses post-sigh, but not spontaneous apnoeas during sleep in rats</atitle><jtitle>Journal of pharmacy and pharmacology</jtitle><addtitle>J Pharm Pharmacol</addtitle><date>2001-11</date><risdate>2001</risdate><volume>53</volume><issue>11</issue><spage>1555</spage><epage>1559</epage><pages>1555-1559</pages><issn>0022-3573</issn><eissn>2042-7158</eissn><abstract>We conducted this experiment to determine the role of glutamate in the mechanism of sleep apnoeas by administering riluzole, a glutamate release inhibitor, to freely moving rats in which sleep‐related apnoeas are physiological phenomena. Adult Sprague‐Dawley rats were implanted with electrodes for electroencephalogram (EEG) and electromyogram (EMG) recording to monitor sleep and were placed inside a single‐chamber plethysmograph to monitor respiration. Sleep and respiration were recorded for 6 h following intraperitoneal administration of 0.5, 5.0 and 10.0 mg kg−1 riluzole. Riluzole dose‐dependently suppressed post‐sigh apnoeas during rapid eye movement (REM) sleep but had no effect on sleep‐related spontaneous apnoeas. The drug (5.0 and 10.0 mg kg−1) also dose‐dependently reduced wakefulness and increased sleep. It appears that glutamate, an excitatory neurotransmitter, plays a role in the genesis of the post‐sigh apnoeas during REM sleep.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>11732759</pmid><doi>10.1211/0022357011777936</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of pharmacy and pharmacology, 2001-11, Vol.53 (11), p.1555-1559 |
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| source | Wiley-Blackwell Journals; MEDLINE; Oxford Academic |
| subjects | Animals Dose-Response Relationship, Drug Excitatory Amino Acid Antagonists - pharmacology Excitatory Amino Acid Antagonists - therapeutic use Male Rats Rats, Sprague-Dawley Receptors, Glutamate - drug effects Receptors, Glutamate - physiology Riluzole - pharmacology Riluzole - therapeutic use Sleep Apnea Syndromes - drug therapy Sleep Apnea Syndromes - physiopathology Sleep, REM - drug effects Wakefulness - drug effects |
| title | Riluzole suppresses post-sigh, but not spontaneous apnoeas during sleep in rats |
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