Quantitative Analysis of the Effect of Phosphoinositide Interactions on the Function of Dbl Family Proteins

Normally, Rho GTPases are activated by the removal of bound GDP and the concomitant loading of GTP catalyzed by members of the Dbl family of guanine nucleotide exchange factors (GEFs). This family of GEFs invariantly contain a Dbl homology (DH) domain adjacent to a pleckstrin homology (PH) domain, a...

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Veröffentlicht in:	The Journal of biological chemistry 2001-12, Vol.276 (49), p.45868-45875
Hauptverfasser:	Snyder, Jason T., Rossman, Kent L., Baumeister, Mark A., Pruitt, Wendy M., Siderovski, David P., Der, Channing J., Lemmon, Mark A., Sondek, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Vesicular Transport Carrier Proteins - metabolism Guanine Nucleotide Exchange Factors - metabolism Immunoblotting Phosphatidylinositols - metabolism Protein Binding Proteins - metabolism Rho Guanine Nucleotide Exchange Factors Surface Plasmon Resonance T-Lymphoma Invasion and Metastasis-inducing Protein 1
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