Agonist-promoted Ubiquitination of the G Protein-coupled Receptor CXCR4 Mediates Lysosomal Sorting

Ligand-induced trafficking plays an important role in the physiologic regulation of many G protein-coupled receptors (GPCRs). Although numerous GPCRs are sorted to a degradative pathway upon prolonged stimulation, the molecular events leading to degradation are poorly understood. Here we report that...

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Veröffentlicht in:	The Journal of biological chemistry 2001-12, Vol.276 (49), p.45509-45512
Hauptverfasser:	Marchese, Adriano, Benovic, Jeffrey L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Cell Line CXCR4 protein Endocytosis GTP-Binding Proteins - metabolism Human immunodeficiency virus Humans Lysosomes - metabolism Molecular Sequence Data Receptors, CXCR4 - agonists Receptors, CXCR4 - chemistry Receptors, CXCR4 - metabolism Sequence Homology, Amino Acid Ubiquitin - metabolism ubiquitination
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