Age-related decreases in GTP-cyclohydrolase-I immunoreactive neurons in the monkey and human substantia nigra

Guanosine triphosphate cyclohydrolase I (GTPCHI) is a critical enzyme in catecholamine function and is rate limiting for the synthesis of the catecholamine co‐factor tetrahydrobiopterin. The present study assessed the distribution of GTPCHI immunoreactivity (‐ir) within the monkey and human ventral...

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Veröffentlicht in:	Journal of comparative neurology (1911) 2000-10, Vol.426 (4), p.534-548
Hauptverfasser:	Chen, Er-Yun, Kallwitz, Eric, Leff, Stuart E., Cochran, Elizabeth J., Mufson, Elliott J., Kordower, Jeffrey H., Mandel, Ronald J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over aging Aging - metabolism Animals Female GTP Cyclohydrolase - metabolism GTPCHI human Humans Macaca mulatta - metabolism Male Mesencephalon - cytology Mesencephalon - enzymology Middle Aged monkeys Neurons - enzymology Parkinson's disease Primates substantia nigra Substantia Nigra - cytology Substantia Nigra - enzymology Tissue Distribution
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