Effect of drugs inhibiting spermidine biosynthesis and metabolism on the in vitro development of Plasmodium falciparum

Treatment of Plasmodium falciparum with the potent inhibitor dicyclohexylamine completely arrests in vitro cell proliferation of the chloroquine-susceptible P. falciparum strain NF54 and the R strain, which shows less sensivity to chloroquine. The average inhibitory concentration (IC50) values deter...

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Veröffentlicht in:	Parasitology research (1987) 2001-11, Vol.87 (11), p.963-972
Hauptverfasser:	KAISER, A, GOTTWALD, A, WIERSCH, C, LINDENTHAL, B, MAIER, W, SEITZ, H. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Agmatine - pharmacology Alkyl and Aryl Transferases - antagonists & inhibitors Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antimalarials - pharmacology Antiparasitic agents Biological and medical sciences Chloroquine - pharmacology Cyclohexylamines - pharmacology Diamines - pharmacology Dose-Response Relationship, Drug Drug Resistance Enzyme Inhibitors - pharmacology Erythrocytes - drug effects Erythrocytes - parasitology Gas Chromatography-Mass Spectrometry Humans Medical sciences Oxidoreductases Acting on CH-NH Group Donors - antagonists & inhibitors Parasitemia - drug therapy Pharmacology. Drug treatments Plasmodium falciparum - drug effects Plasmodium falciparum - enzymology Plasmodium falciparum - growth & development Polyamines - analysis Spermidine - analysis Spermidine - biosynthesis Spermidine - pharmacology
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