Effects of ACE Inhibitor, AT1 Antagonist, and Combined Treatment in Mice with Heart Failure

We tested the hypothesis that a combination of angiotensin-converting enzyme inhibitor (ACEi) and angiotensin II type 1 receptor antagonist (AT1-ant) may have an additive cardioprotective effect in mice with heart failure (HF), because these two agents could have other mechanisms of action besides i...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 2000-10, Vol.36 (4), p.472-480
Hauptverfasser:	Cavasin, Maria A, Yang, Xiao-Ping, Liu, Yun-He, Mehta, Dharmesh, Karumanchi, Rama, Bulagannawar, Manohar, Carretero, Oscar A
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin I - antagonists & inhibitors Angiotensin I - blood Angiotensin II - blood Angiotensin-Converting Enzyme Inhibitors - therapeutic use Animals Antihypertensive Agents - therapeutic use Biological and medical sciences Cardiac Output - drug effects Cardiovascular system Chronic Disease Echocardiography Female Heart - drug effects Heart - physiology Heart Failure - drug therapy Heart Failure - mortality Imidazoles - therapeutic use Male Medical sciences Mice Mice, Inbred C57BL Miscellaneous Myocardial Infarction - pathology Myocardium - pathology Organ Size - drug effects Pharmacology. Drug treatments Ramipril - therapeutic use Stroke Volume - drug effects Stroke Volume - physiology Tetrazoles - therapeutic use Ventricular Remodeling - drug effects
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