The Protein Tyrosine Phosphatase-PEST Is Implicated in the Negative Regulation of Epidermal Growth Factor on PRL Signaling in Mammary Epithelial Cells

Treatment of HC11 mammary epithelial cells with the lactogenic hormone PRL promotes differentiation and induction of milk protein gene expression via stimulation of the Janus kinase (JAK)/signal transducer and activator of transcription pathway. We have previously shown that autocrine activation of...

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Veröffentlicht in:	Molecular endocrinology (Baltimore, Md.) Md.), 2001-12, Vol.15 (12), p.2182-2196
Hauptverfasser:	Horsch, Kay, Schaller, Michael D, Hynes, Nancy E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Cells, Cultured DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - physiology Electrophoresis, Polyacrylamide Gel Epidermal Growth Factor - pharmacology Female Gene Expression Regulation Janus Kinase 2 Luciferases - analysis Mammary Glands, Animal - enzymology Mammary Glands, Animal - physiology Mice Milk Proteins Precipitin Tests Prolactin - physiology Protein Tyrosine Phosphatase, Non-Receptor Type 12 Protein Tyrosine Phosphatases - physiology Protein-Tyrosine Kinases - antagonists & inhibitors Protein-Tyrosine Kinases - metabolism Protein-Tyrosine Kinases - physiology Proto-Oncogene Proteins STAT5 Transcription Factor Trans-Activators - antagonists & inhibitors Trans-Activators - physiology
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