Efficacy of a 1-week pantoprazole triple therapy in eradicating Helicobacter pylori in Asian patients

Background : The aim of the present paper was to determine the efficacy and tolerability of a 1‐week treatment regimen consisting of pantoprazole and two antibiotics: clarithromycin and amoxycillin, in the eradication of Helicobacter pylori. Methods : The patients selected had unequivocal evidence o...

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Veröffentlicht in:Journal of gastroenterology and hepatology 2000-08, Vol.15 (8), p.910-914
Hauptverfasser: Goh, Kl, Parasakthi, N, Cheah, Pl, Ranjeev, Ck, Rosmawati, M, Tan, Ym, Chin, Sc
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container_end_page 914
container_issue 8
container_start_page 910
container_title Journal of gastroenterology and hepatology
container_volume 15
creator Goh, Kl
Parasakthi, N
Cheah, Pl
Ranjeev, Ck
Rosmawati, M
Tan, Ym
Chin, Sc
description Background : The aim of the present paper was to determine the efficacy and tolerability of a 1‐week treatment regimen consisting of pantoprazole and two antibiotics: clarithromycin and amoxycillin, in the eradication of Helicobacter pylori. Methods : The patients selected had unequivocal evidence of H. pylori infection based on urease test, culture and histology on antral and corpus biopsies obtained at endoscopy. Patients received pantoprazole 40 mg twice a day, clarithromycin 500 mg twice a day and amoxycillin 1 g twice a day for 1 week and were assessed for successful eradication at least 4 weeks after completion of therapy by repeat gastroscopy and gastric biopsies. Eradication was defined as absence of bacteria in both antral and corpus biopsies tested by culture, histology and urease test. Results : One hundred and six patients were recruited for the study. The mean age was 48.0 years (range: 23–74 years). Four patients defaulted follow up and five patients were not compliant (taking less than 85%) with medications. Eradication rates on per‐protocol analysis were: 88/97 (90.7%; 95% CI: 83.1–95.7); and on intention‐to‐treat analysis they were: 88/106 (83.0%; 95% CI: 75.9–90.2). Side‐effects were in general mild and tolerable: 57 of 106 (53.7%) patients complained of a bitter taste; 15 (14.1%) complained of giddiness; 10 (9.4%) complained of increased abdominal pain; 11 (11.5%) complained of lethargy and 16 (15.1%) complained of loose motions. Pre‐treatment metronidazole resistance was encountered in 57/74 strains (77.0%). Clarithromycin resistance was not encountered in any of the strains. Conclusions : The pantoprazole 1‐week triple therapy with amoxycillin and clarithromycin is effective in H. pylori eradication. The treatment was well tolerated by patients. Metronidazole resistance was reported in a high percentage of strains isolated from patients. Clarithromycin resistance was, however, not detected in any of the strains.
doi_str_mv 10.1046/j.1440-1746.2000.02229.x
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Methods : The patients selected had unequivocal evidence of H. pylori infection based on urease test, culture and histology on antral and corpus biopsies obtained at endoscopy. Patients received pantoprazole 40 mg twice a day, clarithromycin 500 mg twice a day and amoxycillin 1 g twice a day for 1 week and were assessed for successful eradication at least 4 weeks after completion of therapy by repeat gastroscopy and gastric biopsies. Eradication was defined as absence of bacteria in both antral and corpus biopsies tested by culture, histology and urease test. Results : One hundred and six patients were recruited for the study. The mean age was 48.0 years (range: 23–74 years). Four patients defaulted follow up and five patients were not compliant (taking less than 85%) with medications. Eradication rates on per‐protocol analysis were: 88/97 (90.7%; 95% CI: 83.1–95.7); and on intention‐to‐treat analysis they were: 88/106 (83.0%; 95% CI: 75.9–90.2). Side‐effects were in general mild and tolerable: 57 of 106 (53.7%) patients complained of a bitter taste; 15 (14.1%) complained of giddiness; 10 (9.4%) complained of increased abdominal pain; 11 (11.5%) complained of lethargy and 16 (15.1%) complained of loose motions. Pre‐treatment metronidazole resistance was encountered in 57/74 strains (77.0%). Clarithromycin resistance was not encountered in any of the strains. Conclusions : The pantoprazole 1‐week triple therapy with amoxycillin and clarithromycin is effective in H. pylori eradication. The treatment was well tolerated by patients. Metronidazole resistance was reported in a high percentage of strains isolated from patients. Clarithromycin resistance was, however, not detected in any of the strains.</description><identifier>ISSN: 0815-9319</identifier><identifier>EISSN: 1440-1746</identifier><identifier>DOI: 10.1046/j.1440-1746.2000.02229.x</identifier><identifier>PMID: 11022833</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Science Pty</publisher><subject>1-week triple therapy ; 2-Pyridinylmethylsulfinylbenzimidazoles ; Adult ; Aged ; Amoxicillin - therapeutic use ; Anti-Bacterial Agents - therapeutic use ; Anti-Ulcer Agents - therapeutic use ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Asian patients ; Benzimidazoles - therapeutic use ; Biological and medical sciences ; Clarithromycin - therapeutic use ; Drug Resistance, Microbial ; Drug Therapy, Combination ; Female ; Helicobacter Infections - drug therapy ; Helicobacter pylori ; Helicobacter pylori eradication ; Humans ; Malaysia ; Male ; Medical sciences ; Metronidazole - pharmacology ; metronidazole and clarithromycin resistance ; Microbial Sensitivity Tests ; Middle Aged ; Omeprazole - analogs &amp; derivatives ; Pantoprazole ; Penicillins - therapeutic use ; Pharmacology. 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Methods : The patients selected had unequivocal evidence of H. pylori infection based on urease test, culture and histology on antral and corpus biopsies obtained at endoscopy. Patients received pantoprazole 40 mg twice a day, clarithromycin 500 mg twice a day and amoxycillin 1 g twice a day for 1 week and were assessed for successful eradication at least 4 weeks after completion of therapy by repeat gastroscopy and gastric biopsies. Eradication was defined as absence of bacteria in both antral and corpus biopsies tested by culture, histology and urease test. Results : One hundred and six patients were recruited for the study. The mean age was 48.0 years (range: 23–74 years). Four patients defaulted follow up and five patients were not compliant (taking less than 85%) with medications. Eradication rates on per‐protocol analysis were: 88/97 (90.7%; 95% CI: 83.1–95.7); and on intention‐to‐treat analysis they were: 88/106 (83.0%; 95% CI: 75.9–90.2). Side‐effects were in general mild and tolerable: 57 of 106 (53.7%) patients complained of a bitter taste; 15 (14.1%) complained of giddiness; 10 (9.4%) complained of increased abdominal pain; 11 (11.5%) complained of lethargy and 16 (15.1%) complained of loose motions. Pre‐treatment metronidazole resistance was encountered in 57/74 strains (77.0%). Clarithromycin resistance was not encountered in any of the strains. Conclusions : The pantoprazole 1‐week triple therapy with amoxycillin and clarithromycin is effective in H. pylori eradication. The treatment was well tolerated by patients. Metronidazole resistance was reported in a high percentage of strains isolated from patients. 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Antiparasitic agents</subject><subject>Asian patients</subject><subject>Benzimidazoles - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Clarithromycin - therapeutic use</subject><subject>Drug Resistance, Microbial</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Helicobacter Infections - drug therapy</subject><subject>Helicobacter pylori</subject><subject>Helicobacter pylori eradication</subject><subject>Humans</subject><subject>Malaysia</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metronidazole - pharmacology</subject><subject>metronidazole and clarithromycin resistance</subject><subject>Microbial Sensitivity Tests</subject><subject>Middle Aged</subject><subject>Omeprazole - analogs &amp; derivatives</subject><subject>Pantoprazole</subject><subject>Penicillins - therapeutic use</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Sulfoxides - therapeutic use</topic><topic>Treatment Outcome</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goh, Kl</creatorcontrib><creatorcontrib>Parasakthi, N</creatorcontrib><creatorcontrib>Cheah, Pl</creatorcontrib><creatorcontrib>Ranjeev, Ck</creatorcontrib><creatorcontrib>Rosmawati, M</creatorcontrib><creatorcontrib>Tan, Ym</creatorcontrib><creatorcontrib>Chin, Sc</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastroenterology and hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goh, Kl</au><au>Parasakthi, N</au><au>Cheah, Pl</au><au>Ranjeev, Ck</au><au>Rosmawati, M</au><au>Tan, Ym</au><au>Chin, Sc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of a 1-week pantoprazole triple therapy in eradicating Helicobacter pylori in Asian patients</atitle><jtitle>Journal of gastroenterology and hepatology</jtitle><addtitle>J Gastroenterol Hepatol</addtitle><date>2000-08</date><risdate>2000</risdate><volume>15</volume><issue>8</issue><spage>910</spage><epage>914</epage><pages>910-914</pages><issn>0815-9319</issn><eissn>1440-1746</eissn><abstract>Background : The aim of the present paper was to determine the efficacy and tolerability of a 1‐week treatment regimen consisting of pantoprazole and two antibiotics: clarithromycin and amoxycillin, in the eradication of Helicobacter pylori. Methods : The patients selected had unequivocal evidence of H. pylori infection based on urease test, culture and histology on antral and corpus biopsies obtained at endoscopy. Patients received pantoprazole 40 mg twice a day, clarithromycin 500 mg twice a day and amoxycillin 1 g twice a day for 1 week and were assessed for successful eradication at least 4 weeks after completion of therapy by repeat gastroscopy and gastric biopsies. Eradication was defined as absence of bacteria in both antral and corpus biopsies tested by culture, histology and urease test. Results : One hundred and six patients were recruited for the study. The mean age was 48.0 years (range: 23–74 years). Four patients defaulted follow up and five patients were not compliant (taking less than 85%) with medications. Eradication rates on per‐protocol analysis were: 88/97 (90.7%; 95% CI: 83.1–95.7); and on intention‐to‐treat analysis they were: 88/106 (83.0%; 95% CI: 75.9–90.2). Side‐effects were in general mild and tolerable: 57 of 106 (53.7%) patients complained of a bitter taste; 15 (14.1%) complained of giddiness; 10 (9.4%) complained of increased abdominal pain; 11 (11.5%) complained of lethargy and 16 (15.1%) complained of loose motions. Pre‐treatment metronidazole resistance was encountered in 57/74 strains (77.0%). Clarithromycin resistance was not encountered in any of the strains. Conclusions : The pantoprazole 1‐week triple therapy with amoxycillin and clarithromycin is effective in H. pylori eradication. The treatment was well tolerated by patients. Metronidazole resistance was reported in a high percentage of strains isolated from patients. Clarithromycin resistance was, however, not detected in any of the strains.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Science Pty</pub><pmid>11022833</pmid><doi>10.1046/j.1440-1746.2000.02229.x</doi><tpages>5</tpages></addata></record>
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subjects 1-week triple therapy
2-Pyridinylmethylsulfinylbenzimidazoles
Adult
Aged
Amoxicillin - therapeutic use
Anti-Bacterial Agents - therapeutic use
Anti-Ulcer Agents - therapeutic use
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Asian patients
Benzimidazoles - therapeutic use
Biological and medical sciences
Clarithromycin - therapeutic use
Drug Resistance, Microbial
Drug Therapy, Combination
Female
Helicobacter Infections - drug therapy
Helicobacter pylori
Helicobacter pylori eradication
Humans
Malaysia
Male
Medical sciences
Metronidazole - pharmacology
metronidazole and clarithromycin resistance
Microbial Sensitivity Tests
Middle Aged
Omeprazole - analogs & derivatives
Pantoprazole
Penicillins - therapeutic use
Pharmacology. Drug treatments
Sulfoxides - therapeutic use
Treatment Outcome
Tropical medicine
title Efficacy of a 1-week pantoprazole triple therapy in eradicating Helicobacter pylori in Asian patients
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