Development of Serum-Free Bioreactor Production of Recombinant Human Thyroid Stimulating Hormone Receptor

For the detection of autoantibodies to thyroid stimulating hormone receptors (TSH‐R) in Graves' disease based on a novel coated tube assay system, human TSH‐R is needed in large amounts. Whereas expression of TSH‐R in bacteria, yeast, or insect cells results in nonfunctional, denaturated recept...

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Veröffentlicht in:	Biotechnology progress 2000-09, Vol.16 (5), p.703-709
Hauptverfasser:	Stiens, Lars R., Büntemeyer, Heino, Lütkemeyer, Dirk, Lehmann, Jürgen, Bergmann, Andreas, Weglöhner, Wolfgang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal cells Biological and medical sciences Bioreactors Biotechnology Culture Media, Serum-Free Establishment of new cell lines, improvement of cultural methods, mass cultures Eukaryotic cell cultures Fundamental and applied biological sciences. Psychology Humans K562 Cells Methods. Procedures. Technologies Receptors, Thyrotropin - biosynthesis serum-free media thyroid-stimulating hormone receptors
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