FcγRIIB1/SHIP-mediated Inhibitory Signaling in B Cells Involves Lipid Rafts

One type of membrane microdomain, enriched in glycosphingolipids and cholesterol and referred to as lipid rafts, has been implicated in the generation of activating signals triggered by a variety of stimuli. Several laboratories, including ours, have recently demonstrated that the B cell receptor (B...

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Veröffentlicht in:	The Journal of biological chemistry 2001-12, Vol.276 (49), p.46371-46378
Hauptverfasser:	Aman, M. Javad, Tosello-Trampont, Annie-Carole, Ravichandran, Kodimangalam
Format:	Artikel
Sprache:	eng
Schlagworte:	AFc receptors Animals Antigens, CD - physiology B-Lymphocytes - metabolism Cell Line Lipid Metabolism Mice Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases Phosphoric Monoester Hydrolases - physiology Protein Transport Receptors, Antigen, B-Cell - physiology Receptors, IgG - physiology SHIP protein Signal Transduction - physiology
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