Impact of baseline symptom severity on future risk of benign prostatic hyperplasia-related outcomes and long-term response to finasteride. The Pless Study Group
To evaluate the long-term effects of finasteride on symptoms, acute urinary retention (AUR), and the need for benign prostatic hyperplasia (BPH)-related surgery in relationship to baseline symptom severity. A total of 3040 men with BPH were treated for 4 years with finasteride or placebo. The change...
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| Veröffentlicht in: | Urology (Ridgewood, N.J.) N.J.), 2000-10, Vol.56 (4), p.610-616 |
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| container_title | Urology (Ridgewood, N.J.) |
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| creator | Kaplan, S Garvin, D Gilhooly, P Koppel, M Labasky, R Milsten, R Reddy, P Rosenberg, S Sussman, D White, C Lee, M Pappas, F Waldstreicher, J |
| description | To evaluate the long-term effects of finasteride on symptoms, acute urinary retention (AUR), and the need for benign prostatic hyperplasia (BPH)-related surgery in relationship to baseline symptom severity.
A total of 3040 men with BPH were treated for 4 years with finasteride or placebo. The changes from baseline in symptoms and the incidence of BPH-related surgery and AUR were determined in men with mild (less than 8), low-moderate (8 to 12), high-moderate (13 to 19), and severe (greater than 19) baseline quasi-American Urological Association symptoms for all patients and for the subgroup with a baseline prostate-specific antigen (PSA) level of 1.4 ng/mL or greater.
In patients who completed the 4-year study, the change in symptom score, stratified by baseline symptom severity, was +1.4 +/- 0.5 (mild), -0.8 +/- 0.3 (low-moderate), -3.6 +/- 0.3 (high-moderate), and -7.7 +/- 0.5 (severe) in finasteride-treated patients and, respectively, +3.4 +/- 0.5, +0.7 +/- 0.3, -1.4 +/- 0.3, and -5.3 +/- 0.6 in placebo-treated patients (between-group P |
| format | Article |
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A total of 3040 men with BPH were treated for 4 years with finasteride or placebo. The changes from baseline in symptoms and the incidence of BPH-related surgery and AUR were determined in men with mild (less than 8), low-moderate (8 to 12), high-moderate (13 to 19), and severe (greater than 19) baseline quasi-American Urological Association symptoms for all patients and for the subgroup with a baseline prostate-specific antigen (PSA) level of 1.4 ng/mL or greater.
In patients who completed the 4-year study, the change in symptom score, stratified by baseline symptom severity, was +1.4 +/- 0.5 (mild), -0.8 +/- 0.3 (low-moderate), -3.6 +/- 0.3 (high-moderate), and -7.7 +/- 0.5 (severe) in finasteride-treated patients and, respectively, +3.4 +/- 0.5, +0.7 +/- 0.3, -1.4 +/- 0.3, and -5.3 +/- 0.6 in placebo-treated patients (between-group P <0.01). The between-group differences were greater in the subgroup of patients with a baseline PSA of 1.4 ng/mL or greater. The risk of BPH-related surgery increased among placebo patients with increasing baseline symptom severity to a greater extent than the risk of AUR. Finasteride reduced the risk of AUR or the need for BPH-related surgery in all subgroups (P <0.001), especially in men with a baseline PSA of 1.4 ng/mL or greater.
Compared with placebo, finasteride had a beneficial effect on symptoms, AUR, and BPH-related surgery in all symptom categories. BPH-related surgery, but not AUR, occurred more commonly in placebo-treated men with more severe baseline symptoms. The greatest absolute benefit of finasteride on symptoms and the reduction in risk of AUR and surgery was in men with higher baseline symptom scores and a baseline PSA level of 1.4 ng/mL or greater.</description><identifier>EISSN: 1527-9995</identifier><identifier>PMID: 11018616</identifier><language>eng</language><publisher>United States</publisher><subject>Aged ; Double-Blind Method ; Finasteride - therapeutic use ; Humans ; Male ; Middle Aged ; Prostate-Specific Antigen - analysis ; Prostatic Hyperplasia - complications ; Prostatic Hyperplasia - diagnosis ; Prostatic Hyperplasia - drug therapy ; Prostatic Hyperplasia - surgery ; Treatment Outcome ; Urinary Retention - etiology ; Urinary Retention - prevention & control</subject><ispartof>Urology (Ridgewood, N.J.), 2000-10, Vol.56 (4), p.610-616</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11018616$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kaplan, S</creatorcontrib><creatorcontrib>Garvin, D</creatorcontrib><creatorcontrib>Gilhooly, P</creatorcontrib><creatorcontrib>Koppel, M</creatorcontrib><creatorcontrib>Labasky, R</creatorcontrib><creatorcontrib>Milsten, R</creatorcontrib><creatorcontrib>Reddy, P</creatorcontrib><creatorcontrib>Rosenberg, S</creatorcontrib><creatorcontrib>Sussman, D</creatorcontrib><creatorcontrib>White, C</creatorcontrib><creatorcontrib>Lee, M</creatorcontrib><creatorcontrib>Pappas, F</creatorcontrib><creatorcontrib>Waldstreicher, J</creatorcontrib><title>Impact of baseline symptom severity on future risk of benign prostatic hyperplasia-related outcomes and long-term response to finasteride. The Pless Study Group</title><title>Urology (Ridgewood, N.J.)</title><addtitle>Urology</addtitle><description>To evaluate the long-term effects of finasteride on symptoms, acute urinary retention (AUR), and the need for benign prostatic hyperplasia (BPH)-related surgery in relationship to baseline symptom severity.
A total of 3040 men with BPH were treated for 4 years with finasteride or placebo. The changes from baseline in symptoms and the incidence of BPH-related surgery and AUR were determined in men with mild (less than 8), low-moderate (8 to 12), high-moderate (13 to 19), and severe (greater than 19) baseline quasi-American Urological Association symptoms for all patients and for the subgroup with a baseline prostate-specific antigen (PSA) level of 1.4 ng/mL or greater.
In patients who completed the 4-year study, the change in symptom score, stratified by baseline symptom severity, was +1.4 +/- 0.5 (mild), -0.8 +/- 0.3 (low-moderate), -3.6 +/- 0.3 (high-moderate), and -7.7 +/- 0.5 (severe) in finasteride-treated patients and, respectively, +3.4 +/- 0.5, +0.7 +/- 0.3, -1.4 +/- 0.3, and -5.3 +/- 0.6 in placebo-treated patients (between-group P <0.01). The between-group differences were greater in the subgroup of patients with a baseline PSA of 1.4 ng/mL or greater. The risk of BPH-related surgery increased among placebo patients with increasing baseline symptom severity to a greater extent than the risk of AUR. Finasteride reduced the risk of AUR or the need for BPH-related surgery in all subgroups (P <0.001), especially in men with a baseline PSA of 1.4 ng/mL or greater.
Compared with placebo, finasteride had a beneficial effect on symptoms, AUR, and BPH-related surgery in all symptom categories. BPH-related surgery, but not AUR, occurred more commonly in placebo-treated men with more severe baseline symptoms. The greatest absolute benefit of finasteride on symptoms and the reduction in risk of AUR and surgery was in men with higher baseline symptom scores and a baseline PSA level of 1.4 ng/mL or greater.</description><subject>Aged</subject><subject>Double-Blind Method</subject><subject>Finasteride - therapeutic use</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prostate-Specific Antigen - analysis</subject><subject>Prostatic Hyperplasia - complications</subject><subject>Prostatic Hyperplasia - diagnosis</subject><subject>Prostatic Hyperplasia - drug therapy</subject><subject>Prostatic Hyperplasia - surgery</subject><subject>Treatment Outcome</subject><subject>Urinary Retention - etiology</subject><subject>Urinary Retention - prevention & control</subject><issn>1527-9995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kM1KAzEUhQdBbK2-gtyVu5Gk85OZpRStQkHB7ksmuWmjM0nMzQjzNj6qRevqwOHjg3POsjmvliJv27aaZZdE74yxuq7FRTbjnPGm5vU8-34eglQJvIFOEvbWIdA0hOQHIPzCaNME3oEZ0xgRoqWPXxad3TsI0VOSySo4TAFj6CVZmUfsZUINfkzKD0ggnYbeu32eMA4QkYJ3hJA8GOskHVur8Q62B4TXHongLY16gnX0Y7jKzo3sCa9Puci2jw_b1VO-eVk_r-43eajKOm-MaJcau9IgR9UJhYUQBVesNGVdamYYirattWpk06JaSmaE6hotqo4VusNikd3-aY-TPkektBssKex76dCPtBPLgleCt0fw5gSO3YB6F6IdZJx2_5cWP70rdt0</recordid><startdate>20001001</startdate><enddate>20001001</enddate><creator>Kaplan, S</creator><creator>Garvin, D</creator><creator>Gilhooly, P</creator><creator>Koppel, M</creator><creator>Labasky, R</creator><creator>Milsten, R</creator><creator>Reddy, P</creator><creator>Rosenberg, S</creator><creator>Sussman, D</creator><creator>White, C</creator><creator>Lee, M</creator><creator>Pappas, F</creator><creator>Waldstreicher, J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20001001</creationdate><title>Impact of baseline symptom severity on future risk of benign prostatic hyperplasia-related outcomes and long-term response to finasteride. The Pless Study Group</title><author>Kaplan, S ; Garvin, D ; Gilhooly, P ; Koppel, M ; Labasky, R ; Milsten, R ; Reddy, P ; Rosenberg, S ; Sussman, D ; White, C ; Lee, M ; Pappas, F ; Waldstreicher, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p546-8f792deb4fe1ecb7ce37731c04f464d0f0e7996dc8a89ec2a0f7cb8d75b03dbe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Aged</topic><topic>Double-Blind Method</topic><topic>Finasteride - therapeutic use</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prostate-Specific Antigen - analysis</topic><topic>Prostatic Hyperplasia - complications</topic><topic>Prostatic Hyperplasia - diagnosis</topic><topic>Prostatic Hyperplasia - drug therapy</topic><topic>Prostatic Hyperplasia - surgery</topic><topic>Treatment Outcome</topic><topic>Urinary Retention - etiology</topic><topic>Urinary Retention - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kaplan, S</creatorcontrib><creatorcontrib>Garvin, D</creatorcontrib><creatorcontrib>Gilhooly, P</creatorcontrib><creatorcontrib>Koppel, M</creatorcontrib><creatorcontrib>Labasky, R</creatorcontrib><creatorcontrib>Milsten, R</creatorcontrib><creatorcontrib>Reddy, P</creatorcontrib><creatorcontrib>Rosenberg, S</creatorcontrib><creatorcontrib>Sussman, D</creatorcontrib><creatorcontrib>White, C</creatorcontrib><creatorcontrib>Lee, M</creatorcontrib><creatorcontrib>Pappas, F</creatorcontrib><creatorcontrib>Waldstreicher, J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Urology (Ridgewood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaplan, S</au><au>Garvin, D</au><au>Gilhooly, P</au><au>Koppel, M</au><au>Labasky, R</au><au>Milsten, R</au><au>Reddy, P</au><au>Rosenberg, S</au><au>Sussman, D</au><au>White, C</au><au>Lee, M</au><au>Pappas, F</au><au>Waldstreicher, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of baseline symptom severity on future risk of benign prostatic hyperplasia-related outcomes and long-term response to finasteride. The Pless Study Group</atitle><jtitle>Urology (Ridgewood, N.J.)</jtitle><addtitle>Urology</addtitle><date>2000-10-01</date><risdate>2000</risdate><volume>56</volume><issue>4</issue><spage>610</spage><epage>616</epage><pages>610-616</pages><eissn>1527-9995</eissn><abstract>To evaluate the long-term effects of finasteride on symptoms, acute urinary retention (AUR), and the need for benign prostatic hyperplasia (BPH)-related surgery in relationship to baseline symptom severity.
A total of 3040 men with BPH were treated for 4 years with finasteride or placebo. The changes from baseline in symptoms and the incidence of BPH-related surgery and AUR were determined in men with mild (less than 8), low-moderate (8 to 12), high-moderate (13 to 19), and severe (greater than 19) baseline quasi-American Urological Association symptoms for all patients and for the subgroup with a baseline prostate-specific antigen (PSA) level of 1.4 ng/mL or greater.
In patients who completed the 4-year study, the change in symptom score, stratified by baseline symptom severity, was +1.4 +/- 0.5 (mild), -0.8 +/- 0.3 (low-moderate), -3.6 +/- 0.3 (high-moderate), and -7.7 +/- 0.5 (severe) in finasteride-treated patients and, respectively, +3.4 +/- 0.5, +0.7 +/- 0.3, -1.4 +/- 0.3, and -5.3 +/- 0.6 in placebo-treated patients (between-group P <0.01). The between-group differences were greater in the subgroup of patients with a baseline PSA of 1.4 ng/mL or greater. The risk of BPH-related surgery increased among placebo patients with increasing baseline symptom severity to a greater extent than the risk of AUR. Finasteride reduced the risk of AUR or the need for BPH-related surgery in all subgroups (P <0.001), especially in men with a baseline PSA of 1.4 ng/mL or greater.
Compared with placebo, finasteride had a beneficial effect on symptoms, AUR, and BPH-related surgery in all symptom categories. BPH-related surgery, but not AUR, occurred more commonly in placebo-treated men with more severe baseline symptoms. The greatest absolute benefit of finasteride on symptoms and the reduction in risk of AUR and surgery was in men with higher baseline symptom scores and a baseline PSA level of 1.4 ng/mL or greater.</abstract><cop>United States</cop><pmid>11018616</pmid><tpages>7</tpages></addata></record> |
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| ispartof | Urology (Ridgewood, N.J.), 2000-10, Vol.56 (4), p.610-616 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Aged Double-Blind Method Finasteride - therapeutic use Humans Male Middle Aged Prostate-Specific Antigen - analysis Prostatic Hyperplasia - complications Prostatic Hyperplasia - diagnosis Prostatic Hyperplasia - drug therapy Prostatic Hyperplasia - surgery Treatment Outcome Urinary Retention - etiology Urinary Retention - prevention & control |
| title | Impact of baseline symptom severity on future risk of benign prostatic hyperplasia-related outcomes and long-term response to finasteride. The Pless Study Group |
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