Comparison of responses to siguazodan, rolipram, and zaprinast in the feline pulmonary vascular bed

The present study was undertaken to investigate and compare responses to the cyclic nucleotide phosphodiesterase inhibitors siguazodan (type III, guanosine 3′,5′-cyclic monophosphate (cGMP)-inhibited adenosine 3′,5′-cyclic monophosphate (cAMP)), rolipram (type IV, cAMP-specific), and zaprinast (type...

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Veröffentlicht in:	European journal of pharmacology 2000-10, Vol.406 (2), p.233-238
Hauptverfasser:	De Witt, Bracken J, Marrone, James R, Kadowitz, Philip J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood Pressure - drug effects cAMP Cardiovascular system Cat Cats cGMP Dose-Response Relationship, Drug Female Fundamental and applied biological sciences. Psychology Guanidines - pharmacology Hemodynamics. Rheology Male Medical sciences Miscellaneous Pharmacology Pharmacology. Drug treatments Phosphodiesterase Phosphodiesterase Inhibitors - pharmacology Pulmonary circulation Pulmonary Circulation - drug effects Purinones - pharmacology Pyridazines - pharmacology Rolipram - pharmacology Vertebrates: cardiovascular system
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