Members of the bHLH-PAS family regulate Shh transcription in forebrain regions of the mouse CNS

The secreted protein sonic hedgehog (Shh) is required to establish patterns of cellular growth and differentiation within ventral regions of the developing CNS. The expression of Shh in the two tissue sources responsible for this activity, the axial mesoderm and the ventral midline of the neural tub...

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Veröffentlicht in:	Development (Cambridge) 2000-11, Vol.127 (21), p.4701-4709
Hauptverfasser:	Epstein, D J, Martinu, L, Michaud, J L, Losos, K M, Fan, C, Joyner, A L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic Helix-Loop-Helix Transcription Factors beta-Galactosidase - genetics Body Patterning Diencephalon - embryology Embryonic Induction Gene Expression Regulation, Developmental Genes, Reporter Hedgehog Proteins Helix-Loop-Helix Motifs helix-loop-helix protein Mesencephalon - embryology Mice Mice, Knockout Mice, Transgenic PAS protein Prosencephalon - embryology Proteins - genetics Shh gene Sim2 gene single-minded gene sonic hedgehog protein Trans-Activators Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic
Online-Zugang:	Volltext
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