Annexin-V imaging for noninvasive detection of cardiac allograft rejection
Heart transplant rejection is characterized pathologically by myocyte necrosis and apoptosis associated with interstitial mononuclear cell infiltration. Any one of these components can be targeted for noninvasive detection of transplant rejection. During apoptotic cell death, phosphatidylserine, a p...
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| Veröffentlicht in: | Nature medicine 2001-12, Vol.7 (12), p.1347-1352 |
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| creator | Narula, Jagat Acio, Elmo R Narula, Navneet Samuels, Louis E Fyfe, Billy Wood, Diana Fitzpatrick, Jane M Raghunath, P.N Tomaszewski, John E Kelly, Christine Steinmetz, Neil Green, Allan Tait, John F Leppo, Jeffrey Blankenberg, Francis G Jain, Diwakar Strauss, H. William |
| description | Heart transplant rejection is characterized pathologically by myocyte necrosis and apoptosis associated with interstitial mononuclear cell infiltration. Any one of these components can be targeted for noninvasive detection of transplant rejection. During apoptotic cell death, phosphatidylserine, a phospholipid that is normally confined to the inner leaflet of cell membrane bilayer, gets exteriorized. Technetium-99m-labeled annexin-V, an endogenous protein that has high affinity for binding to phosphatidylserine, has been administered intravenously for noninvasive identification of apoptotic cell death. In the present study of 18 cardiac allograft recipients, 13 patients had negative and five had positive myocardial uptake of annexin. These latter five demonstrated at least moderate transplant rejection and caspase-3 staining, suggesting apoptosis in their biopsy specimens. This study reveals the clinical feasibility and safety of annexin-V imaging for noninvasive detection of transplant rejection by targeting cell membrane phospholipid alterations that are commonly associated with the process of apoptosis. |
| doi_str_mv | 10.1038/nm1201-1347 |
| format | Article |
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William</creator><creatorcontrib>Narula, Jagat ; Acio, Elmo R ; Narula, Navneet ; Samuels, Louis E ; Fyfe, Billy ; Wood, Diana ; Fitzpatrick, Jane M ; Raghunath, P.N ; Tomaszewski, John E ; Kelly, Christine ; Steinmetz, Neil ; Green, Allan ; Tait, John F ; Leppo, Jeffrey ; Blankenberg, Francis G ; Jain, Diwakar ; Strauss, H. William</creatorcontrib><description>Heart transplant rejection is characterized pathologically by myocyte necrosis and apoptosis associated with interstitial mononuclear cell infiltration. Any one of these components can be targeted for noninvasive detection of transplant rejection. During apoptotic cell death, phosphatidylserine, a phospholipid that is normally confined to the inner leaflet of cell membrane bilayer, gets exteriorized. Technetium-99m-labeled annexin-V, an endogenous protein that has high affinity for binding to phosphatidylserine, has been administered intravenously for noninvasive identification of apoptotic cell death. In the present study of 18 cardiac allograft recipients, 13 patients had negative and five had positive myocardial uptake of annexin. These latter five demonstrated at least moderate transplant rejection and caspase-3 staining, suggesting apoptosis in their biopsy specimens. This study reveals the clinical feasibility and safety of annexin-V imaging for noninvasive detection of transplant rejection by targeting cell membrane phospholipid alterations that are commonly associated with the process of apoptosis.</description><identifier>ISSN: 1078-8956</identifier><identifier>EISSN: 1546-170X</identifier><identifier>DOI: 10.1038/nm1201-1347</identifier><identifier>PMID: 11726976</identifier><language>eng</language><publisher>United States: Nature Publishing Group</publisher><subject>Adult ; Aged ; Annexin A5 ; annexin V ; Apoptosis ; Biological Transport ; Biopsy ; Breath tests ; Cardiomyopathy ; Cell death ; Female ; Graft Rejection - diagnostic imaging ; Heart Transplantation - diagnostic imaging ; Heart Transplantation - immunology ; Heart transplants ; Humans ; Infiltration ; Injections, Intravenous ; Male ; Membranes ; Middle Aged ; Mortality ; Myocardium - immunology ; Myocardium - pathology ; Organotechnetium Compounds ; Patients ; Publishing ; Radionuclide Imaging - methods ; Technetium ; technetium-99m</subject><ispartof>Nature medicine, 2001-12, Vol.7 (12), p.1347-1352</ispartof><rights>COPYRIGHT 2001 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Dec 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c613t-4efa4d99643e484002fa559f10569ce9d07da2e82bc1ef1069639326c8b693563</citedby><cites>FETCH-LOGICAL-c613t-4efa4d99643e484002fa559f10569ce9d07da2e82bc1ef1069639326c8b693563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,2729,27931,27932</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11726976$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Narula, Jagat</creatorcontrib><creatorcontrib>Acio, Elmo R</creatorcontrib><creatorcontrib>Narula, Navneet</creatorcontrib><creatorcontrib>Samuels, Louis E</creatorcontrib><creatorcontrib>Fyfe, Billy</creatorcontrib><creatorcontrib>Wood, Diana</creatorcontrib><creatorcontrib>Fitzpatrick, Jane M</creatorcontrib><creatorcontrib>Raghunath, P.N</creatorcontrib><creatorcontrib>Tomaszewski, John E</creatorcontrib><creatorcontrib>Kelly, Christine</creatorcontrib><creatorcontrib>Steinmetz, Neil</creatorcontrib><creatorcontrib>Green, Allan</creatorcontrib><creatorcontrib>Tait, John F</creatorcontrib><creatorcontrib>Leppo, Jeffrey</creatorcontrib><creatorcontrib>Blankenberg, Francis G</creatorcontrib><creatorcontrib>Jain, Diwakar</creatorcontrib><creatorcontrib>Strauss, H. William</creatorcontrib><title>Annexin-V imaging for noninvasive detection of cardiac allograft rejection</title><title>Nature medicine</title><addtitle>Nat Med</addtitle><description>Heart transplant rejection is characterized pathologically by myocyte necrosis and apoptosis associated with interstitial mononuclear cell infiltration. Any one of these components can be targeted for noninvasive detection of transplant rejection. During apoptotic cell death, phosphatidylserine, a phospholipid that is normally confined to the inner leaflet of cell membrane bilayer, gets exteriorized. Technetium-99m-labeled annexin-V, an endogenous protein that has high affinity for binding to phosphatidylserine, has been administered intravenously for noninvasive identification of apoptotic cell death. In the present study of 18 cardiac allograft recipients, 13 patients had negative and five had positive myocardial uptake of annexin. These latter five demonstrated at least moderate transplant rejection and caspase-3 staining, suggesting apoptosis in their biopsy specimens. This study reveals the clinical feasibility and safety of annexin-V imaging for noninvasive detection of transplant rejection by targeting cell membrane phospholipid alterations that are commonly associated with the process of apoptosis.</description><subject>Adult</subject><subject>Aged</subject><subject>Annexin A5</subject><subject>annexin V</subject><subject>Apoptosis</subject><subject>Biological Transport</subject><subject>Biopsy</subject><subject>Breath tests</subject><subject>Cardiomyopathy</subject><subject>Cell death</subject><subject>Female</subject><subject>Graft Rejection - diagnostic imaging</subject><subject>Heart Transplantation - diagnostic imaging</subject><subject>Heart Transplantation - immunology</subject><subject>Heart transplants</subject><subject>Humans</subject><subject>Infiltration</subject><subject>Injections, Intravenous</subject><subject>Male</subject><subject>Membranes</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Myocardium - immunology</subject><subject>Myocardium - pathology</subject><subject>Organotechnetium Compounds</subject><subject>Patients</subject><subject>Publishing</subject><subject>Radionuclide Imaging - methods</subject><subject>Technetium</subject><subject>technetium-99m</subject><issn>1078-8956</issn><issn>1546-170X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0strFDEcB_Agiq2rJ-8yeiiITM1rMpPjUnxUCgUfxVvIZn6ZZplNapIp7X_fLLNoVwpKDgnJJz_y-CL0kuBjgln33m8IxaQmjLeP0CFpuKhJi38-LmPcdnUnG3GAnqW0xhgz3Min6ICQlgrZikP0Zek93DhfX1Ruowfnh8qGWPngnb_WyV1D1UMGk13wVbCV0bF32lR6HMMQtc1VhPW8_Bw9sXpM8GLXL9CPjx--n3yuz84_nZ4sz2ojCMs1B6t5L6XgDHjHMaZWN420BDdCGpA9bntNoaMrQ6DMCimYZFSYbiUkawRboKO57lUMvyZIWW1cMjCO2kOYkmopI5yy5p-QdFQI2pEC3_wF12GKvlxC0VKMdLwcdoHqGQ16BOW8DTlqM4CHqMfgwboyvSSS8XJM3hV__IAvrYeNMw9ueLu3oZgMN3nQU0rq9NvX_7fnF_v26J69BD3myxTGaftnaR--m6GJIaUIVl3FEop4qwhW26ipOWpqG7WiX-0ebVptoP9jd9kq4PUMvM5ThN_gXl7ZHc_u1Fo</recordid><startdate>20011201</startdate><enddate>20011201</enddate><creator>Narula, Jagat</creator><creator>Acio, Elmo R</creator><creator>Narula, Navneet</creator><creator>Samuels, Louis E</creator><creator>Fyfe, Billy</creator><creator>Wood, Diana</creator><creator>Fitzpatrick, Jane M</creator><creator>Raghunath, P.N</creator><creator>Tomaszewski, John E</creator><creator>Kelly, Christine</creator><creator>Steinmetz, Neil</creator><creator>Green, Allan</creator><creator>Tait, John F</creator><creator>Leppo, Jeffrey</creator><creator>Blankenberg, Francis G</creator><creator>Jain, Diwakar</creator><creator>Strauss, H. 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William</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Annexin-V imaging for noninvasive detection of cardiac allograft rejection</atitle><jtitle>Nature medicine</jtitle><addtitle>Nat Med</addtitle><date>2001-12-01</date><risdate>2001</risdate><volume>7</volume><issue>12</issue><spage>1347</spage><epage>1352</epage><pages>1347-1352</pages><issn>1078-8956</issn><eissn>1546-170X</eissn><abstract>Heart transplant rejection is characterized pathologically by myocyte necrosis and apoptosis associated with interstitial mononuclear cell infiltration. Any one of these components can be targeted for noninvasive detection of transplant rejection. During apoptotic cell death, phosphatidylserine, a phospholipid that is normally confined to the inner leaflet of cell membrane bilayer, gets exteriorized. Technetium-99m-labeled annexin-V, an endogenous protein that has high affinity for binding to phosphatidylserine, has been administered intravenously for noninvasive identification of apoptotic cell death. In the present study of 18 cardiac allograft recipients, 13 patients had negative and five had positive myocardial uptake of annexin. These latter five demonstrated at least moderate transplant rejection and caspase-3 staining, suggesting apoptosis in their biopsy specimens. This study reveals the clinical feasibility and safety of annexin-V imaging for noninvasive detection of transplant rejection by targeting cell membrane phospholipid alterations that are commonly associated with the process of apoptosis.</abstract><cop>United States</cop><pub>Nature Publishing Group</pub><pmid>11726976</pmid><doi>10.1038/nm1201-1347</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Aged Annexin A5 annexin V Apoptosis Biological Transport Biopsy Breath tests Cardiomyopathy Cell death Female Graft Rejection - diagnostic imaging Heart Transplantation - diagnostic imaging Heart Transplantation - immunology Heart transplants Humans Infiltration Injections, Intravenous Male Membranes Middle Aged Mortality Myocardium - immunology Myocardium - pathology Organotechnetium Compounds Patients Publishing Radionuclide Imaging - methods Technetium technetium-99m |
| title | Annexin-V imaging for noninvasive detection of cardiac allograft rejection |
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