Relative roles of endothelial cell damage and platelet activation in primary Raynaud's phenomenon (RP) and RP secondary to systemic sclerosis
Objective : To evaluate the relative roles of endothelium and platelets in the pathogenesis of primary RP and RP secondary to SSc. Methods : Endothelial derived ET-1, t-PA, PAI-1, and platelet derived g -TG, PDGF, TGF- g were measured in 36 patients with primary RP, 14 patients with...
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| Veröffentlicht in: | Scandinavian journal of rheumatology 2001, Vol.30 (5), p.290-296 |
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| container_title | Scandinavian journal of rheumatology |
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| creator | Silveri, Rossella De Angelis, Andreina Poggi, Stefania Muti, Giuseppe Bonapace, Franco Argentati, Claudio Cervini, Ferdinando |
| description | Objective : To evaluate the relative roles of endothelium and platelets in the pathogenesis of primary RP and RP secondary to SSc. Methods : Endothelial derived ET-1, t-PA, PAI-1, and platelet derived g -TG, PDGF, TGF- g were measured in 36 patients with primary RP, 14 patients with RP secondary to SSc and 30 age and sex matched controls. Results : A significative increase of ET-1, t-PA, PAI-1, TGF- g, and g -TG were the most relevant changes in patients with RP secondary to SSc with respect to the controls. Less relevant increases of t-PA, PAI-1, PDGF, and g -TG levels were observed in patients with primary RP vs controls. Conclusions : These data seem to confirm the involvement of endothelial cells and platelets in the pathogenesis of RP, with mild changes in primary RP and more relevant changes in RP secondary to SSc. |
| doi_str_mv | 10.1080/030097401753180372 |
| format | Article |
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Methods : Endothelial derived ET-1, t-PA, PAI-1, and platelet derived &#103 -TG, PDGF, TGF- &#103 were measured in 36 patients with primary RP, 14 patients with RP secondary to SSc and 30 age and sex matched controls. Results : A significative increase of ET-1, t-PA, PAI-1, TGF- &#103, and &#103 -TG were the most relevant changes in patients with RP secondary to SSc with respect to the controls. Less relevant increases of t-PA, PAI-1, PDGF, and &#103 -TG levels were observed in patients with primary RP vs controls. Conclusions : These data seem to confirm the involvement of endothelial cells and platelets in the pathogenesis of RP, with mild changes in primary RP and more relevant changes in RP secondary to SSc.</description><identifier>ISSN: 0300-9742</identifier><identifier>EISSN: 1502-7732</identifier><identifier>DOI: 10.1080/030097401753180372</identifier><identifier>PMID: 11727844</identifier><identifier>CODEN: SJRHAT</identifier><language>eng</language><publisher>Colchester: Informa UK Ltd</publisher><subject>Adult ; beta-Thromboglobulin - analysis ; Biological and medical sciences ; Biomarkers - blood ; Endothelin-1 - blood ; Endothelium - cytology ; Endothelium - pathology ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Plasminogen Activator Inhibitor 1 - blood ; Platelet Activation ; Platelet-Derived Growth Factor - analysis ; Raynaud Disease - physiopathology ; Raynaud'S Phenomenon Systemic Sclerosis Endothelial Cells Platelet Release Reaction ; Sarcoidosis. 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Vasculitis ; Scleroderma, Systemic - complications ; Tissue Plasminogen Activator - blood ; Transforming Growth Factor beta - blood</subject><ispartof>Scandinavian journal of rheumatology, 2001, Vol.30 (5), p.290-296</ispartof><rights>2001 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2001</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-a904d44f3e53e695b72c0e0d9f88258acb946019b127384c9c5cf778b63501083</citedby><cites>FETCH-LOGICAL-c466t-a904d44f3e53e695b72c0e0d9f88258acb946019b127384c9c5cf778b63501083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/030097401753180372$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/030097401753180372$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,776,780,4010,27900,27901,27902,59620,59726,60409,60515,61194,61229,61375,61410</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14103546$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14122480$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11727844$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Silveri, Rossella De Angelis, Andreina Poggi, Stefania Muti, Giuseppe Bonapace, Franco Argentati, Claudio Cervini, Ferdinando</creatorcontrib><title>Relative roles of endothelial cell damage and platelet activation in primary Raynaud's phenomenon (RP) and RP secondary to systemic sclerosis</title><title>Scandinavian journal of rheumatology</title><addtitle>Scand J Rheumatol</addtitle><description>Objective : To evaluate the relative roles of endothelium and platelets in the pathogenesis of primary RP and RP secondary to SSc. Methods : Endothelial derived ET-1, t-PA, PAI-1, and platelet derived &#103 -TG, PDGF, TGF- &#103 were measured in 36 patients with primary RP, 14 patients with RP secondary to SSc and 30 age and sex matched controls. Results : A significative increase of ET-1, t-PA, PAI-1, TGF- &#103, and &#103 -TG were the most relevant changes in patients with RP secondary to SSc with respect to the controls. Less relevant increases of t-PA, PAI-1, PDGF, and &#103 -TG levels were observed in patients with primary RP vs controls. Conclusions : These data seem to confirm the involvement of endothelial cells and platelets in the pathogenesis of RP, with mild changes in primary RP and more relevant changes in RP secondary to SSc.</description><subject>Adult</subject><subject>beta-Thromboglobulin - analysis</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Endothelin-1 - blood</subject><subject>Endothelium - cytology</subject><subject>Endothelium - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Plasminogen Activator Inhibitor 1 - blood</subject><subject>Platelet Activation</subject><subject>Platelet-Derived Growth Factor - analysis</subject><subject>Raynaud Disease - physiopathology</subject><subject>Raynaud'S Phenomenon Systemic Sclerosis Endothelial Cells Platelet Release Reaction</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>Scleroderma, Systemic - complications</subject><subject>Tissue Plasminogen Activator - blood</subject><subject>Transforming Growth Factor beta - blood</subject><issn>0300-9742</issn><issn>1502-7732</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2LFDEQhoMo7rj6BzxILrp6aK18dKcb9LAsfsGCy6DnpiZd7fSSTsakW5kf4X8247QsIqyHkMvzvFTVy9hjAS8F1PAKFEBjNAhTKlGDMvIOW4kSZGGMknfZ6gAUmZAn7EFK1wCgG9PcZydCGGlqrVfs55ocTsN34jE4Sjz0nHwXpi25AR235BzvcMSvxNF3fJdhcjRxtFnKYvB88HwXhxHjnq9x73HuzhLfbcmHMT_Pn6-vXvyW11c8kQ2-O6BT4GmfJhoHy5N1FEMa0kN2r0eX6NHyn7Iv795-vvhQXH56__Hi_LKwuqqmAhvQnda9olJR1ZQbIy0QdE1f17Ks0W4aXYFoNkIaVWvb2NL2xtSbSpWQT6dO2bNj7i6GbzOlqR2HdNgVPYU5tUYqoUphMiiPoM3zpUh9u6zaCmgPJbT_lpClJ0v6vBmpu1GWq2fg6QJgsuj6iN4O6YbTQkqds_7PgSp1lbk3R27wfYgj_gjRde2EexfiH0ndOvDrv_wtoZu2FiO112GOPldx276_ALzmwfM</recordid><startdate>2001</startdate><enddate>2001</enddate><creator>Silveri, Rossella De Angelis, Andreina Poggi, Stefania Muti, Giuseppe Bonapace, Franco Argentati, Claudio Cervini, Ferdinando</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2001</creationdate><title>Relative roles of endothelial cell damage and platelet activation in primary Raynaud's phenomenon (RP) and RP secondary to systemic sclerosis</title><author>Silveri, Rossella De Angelis, Andreina Poggi, Stefania Muti, Giuseppe Bonapace, Franco Argentati, Claudio Cervini, Ferdinando</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-a904d44f3e53e695b72c0e0d9f88258acb946019b127384c9c5cf778b63501083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>beta-Thromboglobulin - analysis</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Endothelin-1 - blood</topic><topic>Endothelium - cytology</topic><topic>Endothelium - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Plasminogen Activator Inhibitor 1 - blood</topic><topic>Platelet Activation</topic><topic>Platelet-Derived Growth Factor - analysis</topic><topic>Raynaud Disease - physiopathology</topic><topic>Raynaud'S Phenomenon Systemic Sclerosis Endothelial Cells Platelet Release Reaction</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Scleroderma, Systemic - complications</topic><topic>Tissue Plasminogen Activator - blood</topic><topic>Transforming Growth Factor beta - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Silveri, Rossella De Angelis, Andreina Poggi, Stefania Muti, Giuseppe Bonapace, Franco Argentati, Claudio Cervini, Ferdinando</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Silveri, Rossella De Angelis, Andreina Poggi, Stefania Muti, Giuseppe Bonapace, Franco Argentati, Claudio Cervini, Ferdinando</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relative roles of endothelial cell damage and platelet activation in primary Raynaud's phenomenon (RP) and RP secondary to systemic sclerosis</atitle><jtitle>Scandinavian journal of rheumatology</jtitle><addtitle>Scand J Rheumatol</addtitle><date>2001</date><risdate>2001</risdate><volume>30</volume><issue>5</issue><spage>290</spage><epage>296</epage><pages>290-296</pages><issn>0300-9742</issn><eissn>1502-7732</eissn><coden>SJRHAT</coden><abstract>Objective : To evaluate the relative roles of endothelium and platelets in the pathogenesis of primary RP and RP secondary to SSc. Methods : Endothelial derived ET-1, t-PA, PAI-1, and platelet derived &#103 -TG, PDGF, TGF- &#103 were measured in 36 patients with primary RP, 14 patients with RP secondary to SSc and 30 age and sex matched controls. Results : A significative increase of ET-1, t-PA, PAI-1, TGF- &#103, and &#103 -TG were the most relevant changes in patients with RP secondary to SSc with respect to the controls. Less relevant increases of t-PA, PAI-1, PDGF, and &#103 -TG levels were observed in patients with primary RP vs controls. Conclusions : These data seem to confirm the involvement of endothelial cells and platelets in the pathogenesis of RP, with mild changes in primary RP and more relevant changes in RP secondary to SSc.</abstract><cop>Colchester</cop><pub>Informa UK Ltd</pub><pmid>11727844</pmid><doi>10.1080/030097401753180372</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Adult beta-Thromboglobulin - analysis Biological and medical sciences Biomarkers - blood Endothelin-1 - blood Endothelium - cytology Endothelium - pathology Female Humans Male Medical sciences Middle Aged Plasminogen Activator Inhibitor 1 - blood Platelet Activation Platelet-Derived Growth Factor - analysis Raynaud Disease - physiopathology Raynaud'S Phenomenon Systemic Sclerosis Endothelial Cells Platelet Release Reaction Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Scleroderma, Systemic - complications Tissue Plasminogen Activator - blood Transforming Growth Factor beta - blood |
| title | Relative roles of endothelial cell damage and platelet activation in primary Raynaud's phenomenon (RP) and RP secondary to systemic sclerosis |
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