Sphingosylphosphorylcholine induces Ca(2+)-sensitization of vascular smooth muscle contraction: possible involvement of rho-kinase

Sphingosylphosphorylcholine (SPC), a sphingolipid, concentration-dependently (1-50 microM) induced contraction and slight elevation of the cytosolic Ca(2+) concentration ([Ca(2+)](i)) in smooth muscle of the pig coronary artery, the result being a marked increase in the force/[Ca(2+)](i) ratio. In a...

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Veröffentlicht in:	FEBS letters 2000-09, Vol.482 (1-2), p.85-90
Hauptverfasser:	Todoroki-Ikeda, N, Mizukami, Y, Mogami, K, Kusuda, T, Yamamoto, K, Miyake, T, Sato, M, Suzuki, S, Yamagata, H, Hokazono, Y, Kobayashi, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - pharmacology Animals Calcium - metabolism Coronary Vessels - drug effects Coronary Vessels - physiology Cytosol - metabolism Enzyme Inhibitors - pharmacology Guanosine Triphosphate - metabolism Histamine - pharmacology In Vitro Techniques Intracellular Signaling Peptides and Proteins Kinetics Muscle Contraction - drug effects Muscle Contraction - physiology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - physiology Phosphorylcholine - analogs & derivatives Phosphorylcholine - pharmacology Potassium - pharmacology Protein-Serine-Threonine Kinases - metabolism Pyridines - pharmacology rho-Associated Kinases Sphingosine - analogs & derivatives Sphingosine - pharmacology Swine
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