Clinical evaluation of 'local contrast enhancement' for oral fluorescein angiograms
Purpose : To describe and assess the clinical impact of ‘local contrast enhancement’ on oral fluorescein angiograms. Methods : Oral fluorescein angiograms (OFA) were performed on 12 patients with a range of diabetic retinopathy. The digital images were processed using two enhancement techniques: his...
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| Veröffentlicht in: | Eye (London) 2000-06, Vol.14 (3a), p.318-318 |
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| creator | Newsom, Richard S B Sinthanayothin, Chanjira Boyce, James Casswell, Anthony G Williamson, Tom H |
| description | Purpose
: To describe and assess the clinical impact of ‘local contrast enhancement’ on oral fluorescein angiograms.
Methods
: Oral fluorescein angiograms (OFA) were performed on 12 patients with a range of diabetic retinopathy. The digital images were processed using two enhancement techniques: histogram equalisation, a widely available method; and ‘local contrast enhancement’. Twelve control images and 24 enhanced images were randomised and subjectively graded for clarity between 1 and 100 on a visual analogue scale by two masked observers. A score of 50% was chosen as the cut-off for clinically useful images.
Results
: The mean score for the unenhanced images was 38.8% (SD 19.4); the histogram equalisation performed better at 54.7% (SD 10.0) (
p
= 0.016) and ‘local contrast enhancement at 69.4% (SD 13.6) (
p
< 0.001). These results equate to a 14.7% improvement in comparison with histogram equalisation and a 30.3% improvement with the ‘local contrast enhancement’ technique. All the ‘local contrast enhancement’ images were clinically useful, compared with 58.3% of the histogram equalisation images (χ
2
2.08,
p
= 0.2), and 33.3% of the control images (χ
2
= 6.75,
p
= 0.01).
Conclusion
: This pilot study has demonstrated the power of ‘local contrast enhancement’ techniques for low-contrast fluorescein angiograms. Using ‘local contrast enhancement’ oral fluorescein angiograms can give high-quality images and may allow safer patient investigation. |
| doi_str_mv | 10.1038/eye.2000.80 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72312234</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72312234</sourcerecordid><originalsourceid>FETCH-LOGICAL-c412t-90ddc3e7b1ce5b2a900b3a4973029c15fa4354c1325110ab7e5d2e331ced1db73</originalsourceid><addsrcrecordid>eNp10M9LwzAUwPEgipvTk3ftQdxBO19-dF2PMvwFAw8qeAtp-jo72mQmrbD_3owOd_IUyPvwEr6EnFOYUOCzO9zghAHAZAYHZEhFOo0TkYhDMoQsgZgx9jkgJ96vAMIwhWMyoBTYNMvYkLzN68pUWtUR_qi6U21lTWTLaFzb7aW2pnXKtxGaL2U0NmjacVRaF1kXxmXdWYdeY2UiZZaVXTrV-FNyVKra49nuHJGPx4f3-XO8eH16md8vYi0oa-MMikJzTHOqMcmZygByrkSWcmCZpkmpBE-Eppwl4b8qTzEpGHIeeEGLPOUjct3vXTv73aFvZVOFv9S1Mmg7L1PGKWNcBHjTQ-2s9w5LuXZVo9xGUpDbhjI0lNuGcgZBX-zWdnmDxd7uogVwtQPKh0ilC2Uqv3eCTlOeBXbbMx8mZolOrmznTCjyz7OXPTeq7Rz-rQtmS4L4BdC9k0U</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72312234</pqid></control><display><type>article</type><title>Clinical evaluation of 'local contrast enhancement' for oral fluorescein angiograms</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Newsom, Richard S B ; Sinthanayothin, Chanjira ; Boyce, James ; Casswell, Anthony G ; Williamson, Tom H</creator><creatorcontrib>Newsom, Richard S B ; Sinthanayothin, Chanjira ; Boyce, James ; Casswell, Anthony G ; Williamson, Tom H</creatorcontrib><description>Purpose
: To describe and assess the clinical impact of ‘local contrast enhancement’ on oral fluorescein angiograms.
Methods
: Oral fluorescein angiograms (OFA) were performed on 12 patients with a range of diabetic retinopathy. The digital images were processed using two enhancement techniques: histogram equalisation, a widely available method; and ‘local contrast enhancement’. Twelve control images and 24 enhanced images were randomised and subjectively graded for clarity between 1 and 100 on a visual analogue scale by two masked observers. A score of 50% was chosen as the cut-off for clinically useful images.
Results
: The mean score for the unenhanced images was 38.8% (SD 19.4); the histogram equalisation performed better at 54.7% (SD 10.0) (
p
= 0.016) and ‘local contrast enhancement at 69.4% (SD 13.6) (
p
< 0.001). These results equate to a 14.7% improvement in comparison with histogram equalisation and a 30.3% improvement with the ‘local contrast enhancement’ technique. All the ‘local contrast enhancement’ images were clinically useful, compared with 58.3% of the histogram equalisation images (χ
2
2.08,
p
= 0.2), and 33.3% of the control images (χ
2
= 6.75,
p
= 0.01).
Conclusion
: This pilot study has demonstrated the power of ‘local contrast enhancement’ techniques for low-contrast fluorescein angiograms. Using ‘local contrast enhancement’ oral fluorescein angiograms can give high-quality images and may allow safer patient investigation.</description><identifier>ISSN: 0950-222X</identifier><identifier>EISSN: 1476-5454</identifier><identifier>DOI: 10.1038/eye.2000.80</identifier><identifier>PMID: 11026992</identifier><identifier>CODEN: EYEEEC</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Administration, Oral ; Biological and medical sciences ; clinical-study ; Contrast Media - administration & dosage ; Diabetic Retinopathy - diagnosis ; Evaluation Studies as Topic ; Fluorescein - administration & dosage ; Fluorescein Angiography - methods ; Humans ; Image Processing, Computer-Assisted - methods ; Investigative techniques, diagnostic techniques (general aspects) ; Laboratory Medicine ; Medical sciences ; Medicine ; Medicine & Public Health ; Ophthalmology ; Otorhinolaryngology. Stomatology. Orbit ; Pharmaceutical Sciences/Technology ; Pilot Projects ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Surgery ; Surgical Oncology</subject><ispartof>Eye (London), 2000-06, Vol.14 (3a), p.318-318</ispartof><rights>College of Ophthalmologists 2000</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-90ddc3e7b1ce5b2a900b3a4973029c15fa4354c1325110ab7e5d2e331ced1db73</citedby><cites>FETCH-LOGICAL-c412t-90ddc3e7b1ce5b2a900b3a4973029c15fa4354c1325110ab7e5d2e331ced1db73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1416739$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11026992$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Newsom, Richard S B</creatorcontrib><creatorcontrib>Sinthanayothin, Chanjira</creatorcontrib><creatorcontrib>Boyce, James</creatorcontrib><creatorcontrib>Casswell, Anthony G</creatorcontrib><creatorcontrib>Williamson, Tom H</creatorcontrib><title>Clinical evaluation of 'local contrast enhancement' for oral fluorescein angiograms</title><title>Eye (London)</title><addtitle>Eye</addtitle><addtitle>Eye (Lond)</addtitle><description>Purpose
: To describe and assess the clinical impact of ‘local contrast enhancement’ on oral fluorescein angiograms.
Methods
: Oral fluorescein angiograms (OFA) were performed on 12 patients with a range of diabetic retinopathy. The digital images were processed using two enhancement techniques: histogram equalisation, a widely available method; and ‘local contrast enhancement’. Twelve control images and 24 enhanced images were randomised and subjectively graded for clarity between 1 and 100 on a visual analogue scale by two masked observers. A score of 50% was chosen as the cut-off for clinically useful images.
Results
: The mean score for the unenhanced images was 38.8% (SD 19.4); the histogram equalisation performed better at 54.7% (SD 10.0) (
p
= 0.016) and ‘local contrast enhancement at 69.4% (SD 13.6) (
p
< 0.001). These results equate to a 14.7% improvement in comparison with histogram equalisation and a 30.3% improvement with the ‘local contrast enhancement’ technique. All the ‘local contrast enhancement’ images were clinically useful, compared with 58.3% of the histogram equalisation images (χ
2
2.08,
p
= 0.2), and 33.3% of the control images (χ
2
= 6.75,
p
= 0.01).
Conclusion
: This pilot study has demonstrated the power of ‘local contrast enhancement’ techniques for low-contrast fluorescein angiograms. Using ‘local contrast enhancement’ oral fluorescein angiograms can give high-quality images and may allow safer patient investigation.</description><subject>Administration, Oral</subject><subject>Biological and medical sciences</subject><subject>clinical-study</subject><subject>Contrast Media - administration & dosage</subject><subject>Diabetic Retinopathy - diagnosis</subject><subject>Evaluation Studies as Topic</subject><subject>Fluorescein - administration & dosage</subject><subject>Fluorescein Angiography - methods</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted - methods</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Laboratory Medicine</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Ophthalmology</subject><subject>Otorhinolaryngology. Stomatology. Orbit</subject><subject>Pharmaceutical Sciences/Technology</subject><subject>Pilot Projects</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><issn>0950-222X</issn><issn>1476-5454</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10M9LwzAUwPEgipvTk3ftQdxBO19-dF2PMvwFAw8qeAtp-jo72mQmrbD_3owOd_IUyPvwEr6EnFOYUOCzO9zghAHAZAYHZEhFOo0TkYhDMoQsgZgx9jkgJ96vAMIwhWMyoBTYNMvYkLzN68pUWtUR_qi6U21lTWTLaFzb7aW2pnXKtxGaL2U0NmjacVRaF1kXxmXdWYdeY2UiZZaVXTrV-FNyVKra49nuHJGPx4f3-XO8eH16md8vYi0oa-MMikJzTHOqMcmZygByrkSWcmCZpkmpBE-Eppwl4b8qTzEpGHIeeEGLPOUjct3vXTv73aFvZVOFv9S1Mmg7L1PGKWNcBHjTQ-2s9w5LuXZVo9xGUpDbhjI0lNuGcgZBX-zWdnmDxd7uogVwtQPKh0ilC2Uqv3eCTlOeBXbbMx8mZolOrmznTCjyz7OXPTeq7Rz-rQtmS4L4BdC9k0U</recordid><startdate>20000601</startdate><enddate>20000601</enddate><creator>Newsom, Richard S B</creator><creator>Sinthanayothin, Chanjira</creator><creator>Boyce, James</creator><creator>Casswell, Anthony G</creator><creator>Williamson, Tom H</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000601</creationdate><title>Clinical evaluation of 'local contrast enhancement' for oral fluorescein angiograms</title><author>Newsom, Richard S B ; Sinthanayothin, Chanjira ; Boyce, James ; Casswell, Anthony G ; Williamson, Tom H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-90ddc3e7b1ce5b2a900b3a4973029c15fa4354c1325110ab7e5d2e331ced1db73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Administration, Oral</topic><topic>Biological and medical sciences</topic><topic>clinical-study</topic><topic>Contrast Media - administration & dosage</topic><topic>Diabetic Retinopathy - diagnosis</topic><topic>Evaluation Studies as Topic</topic><topic>Fluorescein - administration & dosage</topic><topic>Fluorescein Angiography - methods</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted - methods</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Laboratory Medicine</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Ophthalmology</topic><topic>Otorhinolaryngology. Stomatology. Orbit</topic><topic>Pharmaceutical Sciences/Technology</topic><topic>Pilot Projects</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Newsom, Richard S B</creatorcontrib><creatorcontrib>Sinthanayothin, Chanjira</creatorcontrib><creatorcontrib>Boyce, James</creatorcontrib><creatorcontrib>Casswell, Anthony G</creatorcontrib><creatorcontrib>Williamson, Tom H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Eye (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Newsom, Richard S B</au><au>Sinthanayothin, Chanjira</au><au>Boyce, James</au><au>Casswell, Anthony G</au><au>Williamson, Tom H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical evaluation of 'local contrast enhancement' for oral fluorescein angiograms</atitle><jtitle>Eye (London)</jtitle><stitle>Eye</stitle><addtitle>Eye (Lond)</addtitle><date>2000-06-01</date><risdate>2000</risdate><volume>14</volume><issue>3a</issue><spage>318</spage><epage>318</epage><pages>318-318</pages><issn>0950-222X</issn><eissn>1476-5454</eissn><coden>EYEEEC</coden><abstract>Purpose
: To describe and assess the clinical impact of ‘local contrast enhancement’ on oral fluorescein angiograms.
Methods
: Oral fluorescein angiograms (OFA) were performed on 12 patients with a range of diabetic retinopathy. The digital images were processed using two enhancement techniques: histogram equalisation, a widely available method; and ‘local contrast enhancement’. Twelve control images and 24 enhanced images were randomised and subjectively graded for clarity between 1 and 100 on a visual analogue scale by two masked observers. A score of 50% was chosen as the cut-off for clinically useful images.
Results
: The mean score for the unenhanced images was 38.8% (SD 19.4); the histogram equalisation performed better at 54.7% (SD 10.0) (
p
= 0.016) and ‘local contrast enhancement at 69.4% (SD 13.6) (
p
< 0.001). These results equate to a 14.7% improvement in comparison with histogram equalisation and a 30.3% improvement with the ‘local contrast enhancement’ technique. All the ‘local contrast enhancement’ images were clinically useful, compared with 58.3% of the histogram equalisation images (χ
2
2.08,
p
= 0.2), and 33.3% of the control images (χ
2
= 6.75,
p
= 0.01).
Conclusion
: This pilot study has demonstrated the power of ‘local contrast enhancement’ techniques for low-contrast fluorescein angiograms. Using ‘local contrast enhancement’ oral fluorescein angiograms can give high-quality images and may allow safer patient investigation.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>11026992</pmid><doi>10.1038/eye.2000.80</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Eye (London), 2000-06, Vol.14 (3a), p.318-318 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Administration, Oral Biological and medical sciences clinical-study Contrast Media - administration & dosage Diabetic Retinopathy - diagnosis Evaluation Studies as Topic Fluorescein - administration & dosage Fluorescein Angiography - methods Humans Image Processing, Computer-Assisted - methods Investigative techniques, diagnostic techniques (general aspects) Laboratory Medicine Medical sciences Medicine Medicine & Public Health Ophthalmology Otorhinolaryngology. Stomatology. Orbit Pharmaceutical Sciences/Technology Pilot Projects Radiodiagnosis. Nmr imagery. Nmr spectrometry Surgery Surgical Oncology |
| title | Clinical evaluation of 'local contrast enhancement' for oral fluorescein angiograms |
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