Regulation of c-fos Induction in Lens Epithelial Cells by 12(S)HETE-Dependent Activation of PKC

12(S)-Hydroxyeicosatetraenoic acid (12(S)HETE), a 12-lipoxygenase metabolite of arachidonic acid, is required for epidermal growth factor (EGF)-dependent DNA synthesis and c-fos induction in lens epithelial cells. The present study was undertaken to identify signal transduction events upstream of c-...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2001-12, Vol.42 (13), p.3239-3246
Hauptverfasser:	Seth, Ranjana K, Haque, M. S. Reza, Zelenka, Peggy S
Format:	Artikel
Sprache:	eng
Schlagworte:	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid - pharmacology Animals Biological and medical sciences Biological Transport Cell Line Enzyme Activation - physiology Enzyme Inhibitors - pharmacology Epidermal Growth Factor - pharmacology Epithelial Cells - drug effects Epithelial Cells - physiology Eye and associated structures. Visual pathways and centers. Vision Flavanones Flavonoids - pharmacology Fundamental and applied biological sciences. Psychology Gene Expression Regulation Genes, fos Indoles - pharmacology Isoenzymes - metabolism Lens, Crystalline - cytology Lens, Crystalline - drug effects Lens, Crystalline - physiology Maleimides - pharmacology Mitogen-Activated Protein Kinases - metabolism Protein Kinase C - antagonists & inhibitors Protein Kinase C - metabolism Protein Kinase C - physiology Rabbits Subcellular Fractions - enzymology Tissue Distribution Vertebrates: nervous system and sense organs
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