Endometrial cavity fluid is associated with poor ovarian response and increased cancellation rates in ART cycles
BACKGROUND: Endometrial cavity fluid (ECF) is occasionally observed during assisted reproductive technology (ART) cycles. However, few reports have described its prevalence or significance. METHODS AND RESULTS: We examined the relationships between ECF, clinical pregnancy rate (CPR), tubal factor in...
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| Veröffentlicht in: | Human reproduction (Oxford) 2001-12, Vol.16 (12), p.2610-2615 |
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| creator | Levi, Andrew J. Segars, James H. Miller, Bradley T. Leondires, Mark P. |
| description | BACKGROUND: Endometrial cavity fluid (ECF) is occasionally observed during assisted reproductive technology (ART) cycles. However, few reports have described its prevalence or significance. METHODS AND RESULTS: We examined the relationships between ECF, clinical pregnancy rate (CPR), tubal factor infertility and ultrasound-visible (USV) hydrosalpinges. In 843 ART cycles involving 721 patients, ECF was observed during stimulation in 57 cycles and after human chorionic gonadotrophin (HCG) administration in 12 cycles, with an overall incidence of 8.2% (69/843). When ECF was observed during stimulation, the cancellation rate due to poor ovarian response was significantly higher (29.8 versus 16.9%, P |
| doi_str_mv | 10.1093/humrep/16.12.2610 |
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However, few reports have described its prevalence or significance. METHODS AND RESULTS: We examined the relationships between ECF, clinical pregnancy rate (CPR), tubal factor infertility and ultrasound-visible (USV) hydrosalpinges. In 843 ART cycles involving 721 patients, ECF was observed during stimulation in 57 cycles and after human chorionic gonadotrophin (HCG) administration in 12 cycles, with an overall incidence of 8.2% (69/843). When ECF was observed during stimulation, the cancellation rate due to poor ovarian response was significantly higher (29.8 versus 16.9%, P <0.05) and the CPR per started cycle was significantly lower (26.3 versus 42.4%, P <0.05) than cycles without ECF. When ECF developed after HCG administration, the CPR was similar compared with that of the group for which ECF was not observed. In the 327 cycles involving tubal factor infertility patients, USV hydrosalpinges were noted in 71 cycles (71/327; 21.7%), and ECF developed in five of those cycles (5/71; 7.0%). A total of 27 cycles during which ECF developed (27/57, 47.4%) involved non-tubal factor patients. CONCLUSIONS: ECF during stimulation was associated with increased cancellation rates and lower CPRs per started cycle, and was not associated with USV hydrosalpinges. Furthermore, ECF observed after HCG administration did not impact CPR and may represent a different clinical entity.</description><identifier>ISSN: 0268-1161</identifier><identifier>EISSN: 1460-2350</identifier><identifier>DOI: 10.1093/humrep/16.12.2610</identifier><identifier>PMID: 11726583</identifier><identifier>CODEN: HUREEE</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Biological and medical sciences ; Birth control ; cancellation rates ; Chorionic Gonadotropin - administration & dosage ; Embryo Transfer ; endometrium ; Endometrium - diagnostic imaging ; Estradiol - blood ; Exudates and Transudates - diagnostic imaging ; Fallopian Tube Diseases - complications ; Fallopian Tube Diseases - diagnostic imaging ; Female ; fluid ; Follicle Stimulating Hormone - blood ; Gynecology. Andrology. Obstetrics ; Humans ; hydrosalpinx ; Infertility, Female - etiology ; Infertility, Female - therapy ; Infertility, Male - therapy ; IVF ; Male ; Medical sciences ; Pregnancy ; Pregnancy Outcome ; Reproductive Techniques ; Sterility. Assisted procreation ; Treatment Failure ; Ultrasonography</subject><ispartof>Human reproduction (Oxford), 2001-12, Vol.16 (12), p.2610-2615</ispartof><rights>European Society of Human Reproduction and Embryology 2001</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-c6e3f72b8edc0b315b41ceb75bba8840ffe446bfd86f8cdaf403aedb4499ace73</citedby><cites>FETCH-LOGICAL-c402t-c6e3f72b8edc0b315b41ceb75bba8840ffe446bfd86f8cdaf403aedb4499ace73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,780,784,789,790,1584,23930,23931,25140,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13377817$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11726583$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Levi, Andrew J.</creatorcontrib><creatorcontrib>Segars, James H.</creatorcontrib><creatorcontrib>Miller, Bradley T.</creatorcontrib><creatorcontrib>Leondires, Mark P.</creatorcontrib><title>Endometrial cavity fluid is associated with poor ovarian response and increased cancellation rates in ART cycles</title><title>Human reproduction (Oxford)</title><addtitle>Hum. Reprod</addtitle><addtitle>Hum. Reprod</addtitle><description>BACKGROUND: Endometrial cavity fluid (ECF) is occasionally observed during assisted reproductive technology (ART) cycles. However, few reports have described its prevalence or significance. METHODS AND RESULTS: We examined the relationships between ECF, clinical pregnancy rate (CPR), tubal factor infertility and ultrasound-visible (USV) hydrosalpinges. In 843 ART cycles involving 721 patients, ECF was observed during stimulation in 57 cycles and after human chorionic gonadotrophin (HCG) administration in 12 cycles, with an overall incidence of 8.2% (69/843). When ECF was observed during stimulation, the cancellation rate due to poor ovarian response was significantly higher (29.8 versus 16.9%, P <0.05) and the CPR per started cycle was significantly lower (26.3 versus 42.4%, P <0.05) than cycles without ECF. When ECF developed after HCG administration, the CPR was similar compared with that of the group for which ECF was not observed. In the 327 cycles involving tubal factor infertility patients, USV hydrosalpinges were noted in 71 cycles (71/327; 21.7%), and ECF developed in five of those cycles (5/71; 7.0%). A total of 27 cycles during which ECF developed (27/57, 47.4%) involved non-tubal factor patients. CONCLUSIONS: ECF during stimulation was associated with increased cancellation rates and lower CPRs per started cycle, and was not associated with USV hydrosalpinges. Furthermore, ECF observed after HCG administration did not impact CPR and may represent a different clinical entity.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Birth control</subject><subject>cancellation rates</subject><subject>Chorionic Gonadotropin - administration & dosage</subject><subject>Embryo Transfer</subject><subject>endometrium</subject><subject>Endometrium - diagnostic imaging</subject><subject>Estradiol - blood</subject><subject>Exudates and Transudates - diagnostic imaging</subject><subject>Fallopian Tube Diseases - complications</subject><subject>Fallopian Tube Diseases - diagnostic imaging</subject><subject>Female</subject><subject>fluid</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>hydrosalpinx</subject><subject>Infertility, Female - etiology</subject><subject>Infertility, Female - therapy</subject><subject>Infertility, Male - therapy</subject><subject>IVF</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Reproductive Techniques</subject><subject>Sterility. Assisted procreation</subject><subject>Treatment Failure</subject><subject>Ultrasonography</subject><issn>0268-1161</issn><issn>1460-2350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0MFu1DAQBmALgehSeAAuyBc4ka0nThzvsSqFIq2EqBYJcbEcZ6wasnHwJIV9e7xkRa-cbMnfPx79jL0EsQaxkRd38z7heAFqDeW6VCAesRVUShSlrMVjthKl0gWAgjP2jOi7EPmq1VN2BtCUqtZyxcbroYt7nFKwPXf2PkwH7vs5dDwQt0TRBTthx3-F6Y6PMSYe723GA09IYxwIuR0yHlxCSxk6OzjsezuFmE3OUn7kl7c77g6uR3rOnnjbE744nefsy_vr3dVNsf304ePV5bZwlSinwimUvilbjZ0TrYS6rcBh29Rta7WuhPdYVar1nVZeu876SkiLXVtVm4112Mhz9maZO6b4c0aazD7Q380GjDOZppQAQtQZwgJdikQJvRlT2Nt0MCDMsWaz1GxAGSjNseaceXUaPrd77B4Sp14zeH0ClpztfcqtBHpwUjaNhuOWbxcX5_G__i0WHmjC3_8CNv0wqpFNbW6-fjM7fbvR7z7vzFb-AR1bp-Y</recordid><startdate>20011201</startdate><enddate>20011201</enddate><creator>Levi, Andrew J.</creator><creator>Segars, James H.</creator><creator>Miller, Bradley T.</creator><creator>Leondires, Mark P.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20011201</creationdate><title>Endometrial cavity fluid is associated with poor ovarian response and increased cancellation rates in ART cycles</title><author>Levi, Andrew J. ; Segars, James H. ; Miller, Bradley T. ; Leondires, Mark P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-c6e3f72b8edc0b315b41ceb75bba8840ffe446bfd86f8cdaf403aedb4499ace73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Birth control</topic><topic>cancellation rates</topic><topic>Chorionic Gonadotropin - administration & dosage</topic><topic>Embryo Transfer</topic><topic>endometrium</topic><topic>Endometrium - diagnostic imaging</topic><topic>Estradiol - blood</topic><topic>Exudates and Transudates - diagnostic imaging</topic><topic>Fallopian Tube Diseases - complications</topic><topic>Fallopian Tube Diseases - diagnostic imaging</topic><topic>Female</topic><topic>fluid</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>hydrosalpinx</topic><topic>Infertility, Female - etiology</topic><topic>Infertility, Female - therapy</topic><topic>Infertility, Male - therapy</topic><topic>IVF</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Reproductive Techniques</topic><topic>Sterility. Assisted procreation</topic><topic>Treatment Failure</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Levi, Andrew J.</creatorcontrib><creatorcontrib>Segars, James H.</creatorcontrib><creatorcontrib>Miller, Bradley T.</creatorcontrib><creatorcontrib>Leondires, Mark P.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human reproduction (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Levi, Andrew J.</au><au>Segars, James H.</au><au>Miller, Bradley T.</au><au>Leondires, Mark P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endometrial cavity fluid is associated with poor ovarian response and increased cancellation rates in ART cycles</atitle><jtitle>Human reproduction (Oxford)</jtitle><stitle>Hum. Reprod</stitle><addtitle>Hum. Reprod</addtitle><date>2001-12-01</date><risdate>2001</risdate><volume>16</volume><issue>12</issue><spage>2610</spage><epage>2615</epage><pages>2610-2615</pages><issn>0268-1161</issn><eissn>1460-2350</eissn><coden>HUREEE</coden><abstract>BACKGROUND: Endometrial cavity fluid (ECF) is occasionally observed during assisted reproductive technology (ART) cycles. However, few reports have described its prevalence or significance. METHODS AND RESULTS: We examined the relationships between ECF, clinical pregnancy rate (CPR), tubal factor infertility and ultrasound-visible (USV) hydrosalpinges. In 843 ART cycles involving 721 patients, ECF was observed during stimulation in 57 cycles and after human chorionic gonadotrophin (HCG) administration in 12 cycles, with an overall incidence of 8.2% (69/843). When ECF was observed during stimulation, the cancellation rate due to poor ovarian response was significantly higher (29.8 versus 16.9%, P <0.05) and the CPR per started cycle was significantly lower (26.3 versus 42.4%, P <0.05) than cycles without ECF. When ECF developed after HCG administration, the CPR was similar compared with that of the group for which ECF was not observed. In the 327 cycles involving tubal factor infertility patients, USV hydrosalpinges were noted in 71 cycles (71/327; 21.7%), and ECF developed in five of those cycles (5/71; 7.0%). A total of 27 cycles during which ECF developed (27/57, 47.4%) involved non-tubal factor patients. CONCLUSIONS: ECF during stimulation was associated with increased cancellation rates and lower CPRs per started cycle, and was not associated with USV hydrosalpinges. Furthermore, ECF observed after HCG administration did not impact CPR and may represent a different clinical entity.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>11726583</pmid><doi>10.1093/humrep/16.12.2610</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Birth control cancellation rates Chorionic Gonadotropin - administration & dosage Embryo Transfer endometrium Endometrium - diagnostic imaging Estradiol - blood Exudates and Transudates - diagnostic imaging Fallopian Tube Diseases - complications Fallopian Tube Diseases - diagnostic imaging Female fluid Follicle Stimulating Hormone - blood Gynecology. Andrology. Obstetrics Humans hydrosalpinx Infertility, Female - etiology Infertility, Female - therapy Infertility, Male - therapy IVF Male Medical sciences Pregnancy Pregnancy Outcome Reproductive Techniques Sterility. Assisted procreation Treatment Failure Ultrasonography |
| title | Endometrial cavity fluid is associated with poor ovarian response and increased cancellation rates in ART cycles |
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