Role of endogenous endothelin on coronary reflow after cardioplegic arrest
Objective: Endothelin plays a role in the regulation of basal coronary tone. We hypothesized that low coronary reflow and reduced cardiac function after prolonged ischemia may be due to increased release of endogenous endothelin. Methods: Using an isolated perfused rat heart, we examined the effect...
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| Veröffentlicht in: | Journal of thoracic and cardiovascular surgery 2001-12, Vol.122 (6), p.1167-1173 |
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| container_title | Journal of thoracic and cardiovascular surgery |
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| creator | Goodwin, Andrew T. Smolenski, Ryszard T. Gray, Caroline C. Jayakumar, Jay Amrani, Mohamed Yacoub, Magdi H. |
| description | Objective: Endothelin plays a role in the regulation of basal coronary tone. We hypothesized that low coronary reflow and reduced cardiac function after prolonged ischemia may be due to increased release of endogenous endothelin. Methods: Using an isolated perfused rat heart, we examined the effect of the addition of various endothelin antagonists during reperfusion after 4 hours of cardioplegic arrest at 4°C. Hearts were freeze-clamped at the end of reperfusion for analysis of high-energy phosphate levels. Results are expressed as the percentages of preischemic values. Results: The addition of bosentan or Ro61-0612 (nonselective endothelin antagonists) resulted in a significant increase in the recovery of coronary flow after 30 minutes of reperfusion (100.9% vs 85.3% [P =.03] and 122.4% vs 83.7% [P |
| doi_str_mv | 10.1067/mtc.2001.115427 |
| format | Article |
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We hypothesized that low coronary reflow and reduced cardiac function after prolonged ischemia may be due to increased release of endogenous endothelin. Methods: Using an isolated perfused rat heart, we examined the effect of the addition of various endothelin antagonists during reperfusion after 4 hours of cardioplegic arrest at 4°C. Hearts were freeze-clamped at the end of reperfusion for analysis of high-energy phosphate levels. Results are expressed as the percentages of preischemic values. Results: The addition of bosentan or Ro61-0612 (nonselective endothelin antagonists) resulted in a significant increase in the recovery of coronary flow after 30 minutes of reperfusion (100.9% vs 85.3% [P =.03] and 122.4% vs 83.7% [P <.001], respectively, versus controls). The addition of PD155080 (endothelin A antagonist) had a similar effect (129.5% vs 91.4%, P =.008). BQ788 (endothelin B antagonist) and phosphoramidon (endothelin-converting enzyme inhibitor) had no effect. Myocardial adenosine triphosphate levels were significantly (12.1%) higher after reperfusion with Ro61-0612 (18.1 ± 0.4 μmol/g vs 16.2 ± 0.5 μmol/g, P =.01). There was no difference in the recovery of cardiac mechanical function with any of the antagonists studied. Conclusion: These results suggest that endogenous endothelin plays a role in low coronary reflow after prolonged cardioplegic arrest but does not impair recovery of myocardial function.</description><identifier>ISSN: 0022-5223</identifier><identifier>EISSN: 1097-685X</identifier><identifier>DOI: 10.1067/mtc.2001.115427</identifier><identifier>PMID: 11726892</identifier><identifier>CODEN: JTCSAQ</identifier><language>eng</language><publisher>Philadelphia, PA: Elsevier Inc</publisher><subject>Anesthesia ; Anesthesia depending on type of surgery ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Animals ; Biological and medical sciences ; Chromatography, High Pressure Liquid ; Coronary Circulation - physiology ; Dioxoles - pharmacology ; Endothelin Receptor Antagonists ; Endothelins - antagonists & inhibitors ; Endothelins - physiology ; Heart Arrest, Induced ; Male ; Medical sciences ; Myocardial Reperfusion Injury - physiopathology ; Perfusion ; Pyridines - pharmacology ; Rats ; Rats, Sprague-Dawley ; Sulfonamides - pharmacology ; Tetrazoles - pharmacology ; Thoracic and cardiovascular surgery. Cardiopulmonary bypass</subject><ispartof>Journal of thoracic and cardiovascular surgery, 2001-12, Vol.122 (6), p.1167-1173</ispartof><rights>2001 American Association for Thoracic Surgery</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-96e84322ac074cd0c78f43ed3fafc49433143567ee3c4d50300bb444932a98183</citedby><cites>FETCH-LOGICAL-c447t-96e84322ac074cd0c78f43ed3fafc49433143567ee3c4d50300bb444932a98183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022522301716935$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13383205$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11726892$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goodwin, Andrew T.</creatorcontrib><creatorcontrib>Smolenski, Ryszard T.</creatorcontrib><creatorcontrib>Gray, Caroline C.</creatorcontrib><creatorcontrib>Jayakumar, Jay</creatorcontrib><creatorcontrib>Amrani, Mohamed</creatorcontrib><creatorcontrib>Yacoub, Magdi H.</creatorcontrib><title>Role of endogenous endothelin on coronary reflow after cardioplegic arrest</title><title>Journal of thoracic and cardiovascular surgery</title><addtitle>J Thorac Cardiovasc Surg</addtitle><description>Objective: Endothelin plays a role in the regulation of basal coronary tone. We hypothesized that low coronary reflow and reduced cardiac function after prolonged ischemia may be due to increased release of endogenous endothelin. Methods: Using an isolated perfused rat heart, we examined the effect of the addition of various endothelin antagonists during reperfusion after 4 hours of cardioplegic arrest at 4°C. Hearts were freeze-clamped at the end of reperfusion for analysis of high-energy phosphate levels. Results are expressed as the percentages of preischemic values. Results: The addition of bosentan or Ro61-0612 (nonselective endothelin antagonists) resulted in a significant increase in the recovery of coronary flow after 30 minutes of reperfusion (100.9% vs 85.3% [P =.03] and 122.4% vs 83.7% [P <.001], respectively, versus controls). The addition of PD155080 (endothelin A antagonist) had a similar effect (129.5% vs 91.4%, P =.008). BQ788 (endothelin B antagonist) and phosphoramidon (endothelin-converting enzyme inhibitor) had no effect. Myocardial adenosine triphosphate levels were significantly (12.1%) higher after reperfusion with Ro61-0612 (18.1 ± 0.4 μmol/g vs 16.2 ± 0.5 μmol/g, P =.01). There was no difference in the recovery of cardiac mechanical function with any of the antagonists studied. Conclusion: These results suggest that endogenous endothelin plays a role in low coronary reflow after prolonged cardioplegic arrest but does not impair recovery of myocardial function.</description><subject>Anesthesia</subject><subject>Anesthesia depending on type of surgery</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Coronary Circulation - physiology</subject><subject>Dioxoles - pharmacology</subject><subject>Endothelin Receptor Antagonists</subject><subject>Endothelins - antagonists & inhibitors</subject><subject>Endothelins - physiology</subject><subject>Heart Arrest, Induced</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Myocardial Reperfusion Injury - physiopathology</subject><subject>Perfusion</subject><subject>Pyridines - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Sulfonamides - pharmacology</subject><subject>Tetrazoles - pharmacology</subject><subject>Thoracic and cardiovascular surgery. Cardiopulmonary bypass</subject><issn>0022-5223</issn><issn>1097-685X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1v1DAQhi0EotvCmRvKBdRLtuOPxPERVbSAKiFVIHGzvJPJrisnXuwsFf--XrJST5zswzPvvPMw9o7DmkOrr8YZ1wKArzlvlNAv2IqD0XXbNb9eshWAEHUjhDxj5zk_AIAGbl6zM861aDsjVuzbfQxUxaGiqY9bmuIh__vOOwp-quJUYUxxculvlWgI8bFyw0ypQpd6H_eBth4rlxLl-Q17NbiQ6e3pvWA_bz7_uP5S332__Xr96a5GpfRcm5Y6JYVwCFphD6i7QUnq5eAGVEZJyZVsWk0kUfUNSIDNRillpHCm4528YB-X3H2Kvw9lsR19RgrBTVTqWy0kmEbLAl4tIKaYc6lv98mP5RTLwR712aLPHvXZRV-ZeH-KPmxG6p_5k68CfDgBLqMLQ3IT-vzMSdlJAU3hLhdu57e7R5_I5tGFUGK5fZgxcyFsW2Lb406zoFSc_fGUbEZPE1JfxnC2ffT_7fsEqruYqA</recordid><startdate>20011201</startdate><enddate>20011201</enddate><creator>Goodwin, Andrew T.</creator><creator>Smolenski, Ryszard T.</creator><creator>Gray, Caroline C.</creator><creator>Jayakumar, Jay</creator><creator>Amrani, Mohamed</creator><creator>Yacoub, Magdi H.</creator><general>Elsevier Inc</general><general>AATS/WTSA</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20011201</creationdate><title>Role of endogenous endothelin on coronary reflow after cardioplegic arrest</title><author>Goodwin, Andrew T. ; Smolenski, Ryszard T. ; Gray, Caroline C. ; Jayakumar, Jay ; Amrani, Mohamed ; Yacoub, Magdi H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-96e84322ac074cd0c78f43ed3fafc49433143567ee3c4d50300bb444932a98183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Anesthesia</topic><topic>Anesthesia depending on type of surgery</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Coronary Circulation - physiology</topic><topic>Dioxoles - pharmacology</topic><topic>Endothelin Receptor Antagonists</topic><topic>Endothelins - antagonists & inhibitors</topic><topic>Endothelins - physiology</topic><topic>Heart Arrest, Induced</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Myocardial Reperfusion Injury - physiopathology</topic><topic>Perfusion</topic><topic>Pyridines - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Sulfonamides - pharmacology</topic><topic>Tetrazoles - pharmacology</topic><topic>Thoracic and cardiovascular surgery. Cardiopulmonary bypass</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goodwin, Andrew T.</creatorcontrib><creatorcontrib>Smolenski, Ryszard T.</creatorcontrib><creatorcontrib>Gray, Caroline C.</creatorcontrib><creatorcontrib>Jayakumar, Jay</creatorcontrib><creatorcontrib>Amrani, Mohamed</creatorcontrib><creatorcontrib>Yacoub, Magdi H.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of thoracic and cardiovascular surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goodwin, Andrew T.</au><au>Smolenski, Ryszard T.</au><au>Gray, Caroline C.</au><au>Jayakumar, Jay</au><au>Amrani, Mohamed</au><au>Yacoub, Magdi H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of endogenous endothelin on coronary reflow after cardioplegic arrest</atitle><jtitle>Journal of thoracic and cardiovascular surgery</jtitle><addtitle>J Thorac Cardiovasc Surg</addtitle><date>2001-12-01</date><risdate>2001</risdate><volume>122</volume><issue>6</issue><spage>1167</spage><epage>1173</epage><pages>1167-1173</pages><issn>0022-5223</issn><eissn>1097-685X</eissn><coden>JTCSAQ</coden><abstract>Objective: Endothelin plays a role in the regulation of basal coronary tone. We hypothesized that low coronary reflow and reduced cardiac function after prolonged ischemia may be due to increased release of endogenous endothelin. Methods: Using an isolated perfused rat heart, we examined the effect of the addition of various endothelin antagonists during reperfusion after 4 hours of cardioplegic arrest at 4°C. Hearts were freeze-clamped at the end of reperfusion for analysis of high-energy phosphate levels. Results are expressed as the percentages of preischemic values. Results: The addition of bosentan or Ro61-0612 (nonselective endothelin antagonists) resulted in a significant increase in the recovery of coronary flow after 30 minutes of reperfusion (100.9% vs 85.3% [P =.03] and 122.4% vs 83.7% [P <.001], respectively, versus controls). The addition of PD155080 (endothelin A antagonist) had a similar effect (129.5% vs 91.4%, P =.008). BQ788 (endothelin B antagonist) and phosphoramidon (endothelin-converting enzyme inhibitor) had no effect. Myocardial adenosine triphosphate levels were significantly (12.1%) higher after reperfusion with Ro61-0612 (18.1 ± 0.4 μmol/g vs 16.2 ± 0.5 μmol/g, P =.01). There was no difference in the recovery of cardiac mechanical function with any of the antagonists studied. Conclusion: These results suggest that endogenous endothelin plays a role in low coronary reflow after prolonged cardioplegic arrest but does not impair recovery of myocardial function.</abstract><cop>Philadelphia, PA</cop><pub>Elsevier Inc</pub><pmid>11726892</pmid><doi>10.1067/mtc.2001.115427</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Anesthesia Anesthesia depending on type of surgery Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Chromatography, High Pressure Liquid Coronary Circulation - physiology Dioxoles - pharmacology Endothelin Receptor Antagonists Endothelins - antagonists & inhibitors Endothelins - physiology Heart Arrest, Induced Male Medical sciences Myocardial Reperfusion Injury - physiopathology Perfusion Pyridines - pharmacology Rats Rats, Sprague-Dawley Sulfonamides - pharmacology Tetrazoles - pharmacology Thoracic and cardiovascular surgery. Cardiopulmonary bypass |
| title | Role of endogenous endothelin on coronary reflow after cardioplegic arrest |
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