Porous polyethylene implant fibrovascularization rate is affected by tissue wrapping, agarose coating, and insertion site
Often used in facial and ocular reconstruction, biointegratable materials, such as hydroxyapatite and high density porous polyethylene, can be associated with migration, exposure, and infection. Complications are less likely after implants become fibrovascularly integrated. A model was sought to stu...
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Veröffentlicht in: | Ophthalmic plastic and reconstructive surgery 2000-09, Vol.16 (5), p.330-336 |
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creator | SOPARKAR, Charles N. S WONG, Jamie F PATRINELY, James R DAVIDSON, Joseph K APPLING, Douglas |
description | Often used in facial and ocular reconstruction, biointegratable materials, such as hydroxyapatite and high density porous polyethylene, can be associated with migration, exposure, and infection. Complications are less likely after implants become fibrovascularly integrated. A model was sought to study the influence of multiple factors on the rate of fibrovascular ingrowth into porous implants.
High density porous polyethylene cubes were implanted into paraspinous skeletal muscles in rabbits. The cubes were explanted at weekly intervals using survival surgery. The number of fibroblasts at the center of each cube was counted, generating a time-dependent standard curve of cell accumulation. Porous polyethylene cubes uncoated, coated with agarose (a plant-derived carbohydrate), or coated with nonperforated sclera (human or rabbit) were implanted into suprascapular adipose and paraspinous skeletal muscle in other rabbits.
Fibrovascular ingrowth occurred more rapidly with cube implantation into skeletal muscle versus adipose, with increased surface area contact between implants and muscle, and with removal of muscle capsules. While the rate of fibroblast accumulation decreased in cubes coated with sclera, coating the cubes with agarose increased the fibrous capsule formation without altering the rate of biointegration.
This study provides a novel approach for the study of fibrovascular ingrowth into implants treated under a variety of conditions. Modification of current surgical techniques may increase the rate of porous polyethylene implant biointegration. |
doi_str_mv | 10.1097/00002341-200009000-00005 |
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High density porous polyethylene cubes were implanted into paraspinous skeletal muscles in rabbits. The cubes were explanted at weekly intervals using survival surgery. The number of fibroblasts at the center of each cube was counted, generating a time-dependent standard curve of cell accumulation. Porous polyethylene cubes uncoated, coated with agarose (a plant-derived carbohydrate), or coated with nonperforated sclera (human or rabbit) were implanted into suprascapular adipose and paraspinous skeletal muscle in other rabbits.
Fibrovascular ingrowth occurred more rapidly with cube implantation into skeletal muscle versus adipose, with increased surface area contact between implants and muscle, and with removal of muscle capsules. While the rate of fibroblast accumulation decreased in cubes coated with sclera, coating the cubes with agarose increased the fibrous capsule formation without altering the rate of biointegration.
This study provides a novel approach for the study of fibrovascular ingrowth into implants treated under a variety of conditions. Modification of current surgical techniques may increase the rate of porous polyethylene implant biointegration.</description><identifier>ISSN: 0740-9303</identifier><identifier>EISSN: 1537-2677</identifier><identifier>DOI: 10.1097/00002341-200009000-00005</identifier><identifier>PMID: 11021381</identifier><identifier>CODEN: OPRSEU</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams and Wilkins</publisher><subject>Adipose Tissue - blood supply ; Adipose Tissue - cytology ; Adipose Tissue - surgery ; Animals ; Biological and medical sciences ; Cell Count ; Coated Materials, Biocompatible ; Fibroblasts - cytology ; Male ; Medical sciences ; Muscle, Skeletal - blood supply ; Muscle, Skeletal - cytology ; Muscle, Skeletal - surgery ; Neovascularization, Physiologic ; Orbital Implants ; Polyethylene ; Porosity ; Prosthesis Implantation ; Rabbits ; Sclera ; Sepharose ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the eye and orbit ; Time Factors</subject><ispartof>Ophthalmic plastic and reconstructive surgery, 2000-09, Vol.16 (5), p.330-336</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-acd7d61a3d6a3a36305faa9be096789e4e3c0d9c8ccf9c152268a062662521433</citedby><cites>FETCH-LOGICAL-c434t-acd7d61a3d6a3a36305faa9be096789e4e3c0d9c8ccf9c152268a062662521433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=788482$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11021381$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SOPARKAR, Charles N. S</creatorcontrib><creatorcontrib>WONG, Jamie F</creatorcontrib><creatorcontrib>PATRINELY, James R</creatorcontrib><creatorcontrib>DAVIDSON, Joseph K</creatorcontrib><creatorcontrib>APPLING, Douglas</creatorcontrib><title>Porous polyethylene implant fibrovascularization rate is affected by tissue wrapping, agarose coating, and insertion site</title><title>Ophthalmic plastic and reconstructive surgery</title><addtitle>Ophthalmic Plast Reconstr Surg</addtitle><description>Often used in facial and ocular reconstruction, biointegratable materials, such as hydroxyapatite and high density porous polyethylene, can be associated with migration, exposure, and infection. Complications are less likely after implants become fibrovascularly integrated. A model was sought to study the influence of multiple factors on the rate of fibrovascular ingrowth into porous implants.
High density porous polyethylene cubes were implanted into paraspinous skeletal muscles in rabbits. The cubes were explanted at weekly intervals using survival surgery. The number of fibroblasts at the center of each cube was counted, generating a time-dependent standard curve of cell accumulation. Porous polyethylene cubes uncoated, coated with agarose (a plant-derived carbohydrate), or coated with nonperforated sclera (human or rabbit) were implanted into suprascapular adipose and paraspinous skeletal muscle in other rabbits.
Fibrovascular ingrowth occurred more rapidly with cube implantation into skeletal muscle versus adipose, with increased surface area contact between implants and muscle, and with removal of muscle capsules. While the rate of fibroblast accumulation decreased in cubes coated with sclera, coating the cubes with agarose increased the fibrous capsule formation without altering the rate of biointegration.
This study provides a novel approach for the study of fibrovascular ingrowth into implants treated under a variety of conditions. Modification of current surgical techniques may increase the rate of porous polyethylene implant biointegration.</description><subject>Adipose Tissue - blood supply</subject><subject>Adipose Tissue - cytology</subject><subject>Adipose Tissue - surgery</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Count</subject><subject>Coated Materials, Biocompatible</subject><subject>Fibroblasts - cytology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Muscle, Skeletal - blood supply</subject><subject>Muscle, Skeletal - cytology</subject><subject>Muscle, Skeletal - surgery</subject><subject>Neovascularization, Physiologic</subject><subject>Orbital Implants</subject><subject>Polyethylene</subject><subject>Porosity</subject><subject>Prosthesis Implantation</subject><subject>Rabbits</subject><subject>Sclera</subject><subject>Sepharose</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the eye and orbit</subject><subject>Time Factors</subject><issn>0740-9303</issn><issn>1537-2677</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkNlKxTAQhoMoelxeQQKCV1aztElzKeIGgl7odZmTTjXS09YkVerTm7OoA2GG4ftnMj8hlLNzzoy-YCmEzHkmlpVJL1sWxRaZ8ULqTCitt8mM6ZxlRjK5R_ZDeGeMa1kUu2SPcya4LPmMTE-978dAh76dML5NLXZI3WJooYu0cXPff0KwYwvefUN0fUc9xEQECk2DNmJN5xONLoQR6ZeHYXDd6xmFV_B9QGr7JFo1upq6LqBfzQgu4iHZaaANeLTJB-Tl5vr56i57eLy9v7p8yGwu85iBrXWtOMhagQSpJCsaADNHZpQuDeYoLauNLa1tjOWFEKoEpoRSohA8l_KAnK7nDr7_GDHEauGCxTZdiOnySgvJTK5MAss1aNPXg8emGrxbgJ8qzqql7dWv7dWf7atWkaTHmx3jfIH1v3DjcwJONkByE9rGQ2dd-ON0WealkD_bm4w2</recordid><startdate>20000901</startdate><enddate>20000901</enddate><creator>SOPARKAR, Charles N. 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S ; WONG, Jamie F ; PATRINELY, James R ; DAVIDSON, Joseph K ; APPLING, Douglas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-acd7d61a3d6a3a36305faa9be096789e4e3c0d9c8ccf9c152268a062662521433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adipose Tissue - blood supply</topic><topic>Adipose Tissue - cytology</topic><topic>Adipose Tissue - surgery</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Count</topic><topic>Coated Materials, Biocompatible</topic><topic>Fibroblasts - cytology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Muscle, Skeletal - blood supply</topic><topic>Muscle, Skeletal - cytology</topic><topic>Muscle, Skeletal - surgery</topic><topic>Neovascularization, Physiologic</topic><topic>Orbital Implants</topic><topic>Polyethylene</topic><topic>Porosity</topic><topic>Prosthesis Implantation</topic><topic>Rabbits</topic><topic>Sclera</topic><topic>Sepharose</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the eye and orbit</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SOPARKAR, Charles N. S</creatorcontrib><creatorcontrib>WONG, Jamie F</creatorcontrib><creatorcontrib>PATRINELY, James R</creatorcontrib><creatorcontrib>DAVIDSON, Joseph K</creatorcontrib><creatorcontrib>APPLING, Douglas</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Ophthalmic plastic and reconstructive surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SOPARKAR, Charles N. S</au><au>WONG, Jamie F</au><au>PATRINELY, James R</au><au>DAVIDSON, Joseph K</au><au>APPLING, Douglas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Porous polyethylene implant fibrovascularization rate is affected by tissue wrapping, agarose coating, and insertion site</atitle><jtitle>Ophthalmic plastic and reconstructive surgery</jtitle><addtitle>Ophthalmic Plast Reconstr Surg</addtitle><date>2000-09-01</date><risdate>2000</risdate><volume>16</volume><issue>5</issue><spage>330</spage><epage>336</epage><pages>330-336</pages><issn>0740-9303</issn><eissn>1537-2677</eissn><coden>OPRSEU</coden><abstract>Often used in facial and ocular reconstruction, biointegratable materials, such as hydroxyapatite and high density porous polyethylene, can be associated with migration, exposure, and infection. Complications are less likely after implants become fibrovascularly integrated. A model was sought to study the influence of multiple factors on the rate of fibrovascular ingrowth into porous implants.
High density porous polyethylene cubes were implanted into paraspinous skeletal muscles in rabbits. The cubes were explanted at weekly intervals using survival surgery. The number of fibroblasts at the center of each cube was counted, generating a time-dependent standard curve of cell accumulation. Porous polyethylene cubes uncoated, coated with agarose (a plant-derived carbohydrate), or coated with nonperforated sclera (human or rabbit) were implanted into suprascapular adipose and paraspinous skeletal muscle in other rabbits.
Fibrovascular ingrowth occurred more rapidly with cube implantation into skeletal muscle versus adipose, with increased surface area contact between implants and muscle, and with removal of muscle capsules. While the rate of fibroblast accumulation decreased in cubes coated with sclera, coating the cubes with agarose increased the fibrous capsule formation without altering the rate of biointegration.
This study provides a novel approach for the study of fibrovascular ingrowth into implants treated under a variety of conditions. Modification of current surgical techniques may increase the rate of porous polyethylene implant biointegration.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams and Wilkins</pub><pmid>11021381</pmid><doi>10.1097/00002341-200009000-00005</doi><tpages>7</tpages></addata></record> |
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subjects | Adipose Tissue - blood supply Adipose Tissue - cytology Adipose Tissue - surgery Animals Biological and medical sciences Cell Count Coated Materials, Biocompatible Fibroblasts - cytology Male Medical sciences Muscle, Skeletal - blood supply Muscle, Skeletal - cytology Muscle, Skeletal - surgery Neovascularization, Physiologic Orbital Implants Polyethylene Porosity Prosthesis Implantation Rabbits Sclera Sepharose Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the eye and orbit Time Factors |
title | Porous polyethylene implant fibrovascularization rate is affected by tissue wrapping, agarose coating, and insertion site |
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