Regulation of Platelet Production: The Normal Response to Perturbation and Cyclical Platelet Disease
An age-structured model for the regulation of platelet production is developed, and compared with both normal and pathological platelet production. We consider the role of thrombopoietin (TPO) in this process, how TPO affects the transition between megakaryocytes of various ploidy classes, and their...
Gespeichert in:
| Veröffentlicht in: | Journal of theoretical biology 2000-10, Vol.206 (4), p.585-603 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 603 |
|---|---|
| container_issue | 4 |
| container_start_page | 585 |
| container_title | Journal of theoretical biology |
| container_volume | 206 |
| creator | SANTILLÁN, MOISÉS MAHAFFY, JOSEPH M BÉLAIR, JACQUES MACKEY, MICHAEL C |
| description | An age-structured model for the regulation of platelet production is developed, and compared with both normal and pathological platelet production. We consider the role of thrombopoietin (TPO) in this process, how TPO affects the transition between megakaryocytes of various ploidy classes, and their individual contributions to platelet production. After the estimation of the relevant parameters of the model from both in vivo and in vitro data, we use the model to numerically reproduce the normal human response to a bolus injection of TPO. We further show that our model reproduces the dynamic characteristics of autoimmune cyclical thromobocytopenia if the rate of platelet destruction in the circulation is elevated to more than twice the normal value. |
| doi_str_mv | 10.1006/jtbi.2000.2149 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72308646</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0022519300921490</els_id><sourcerecordid>72308646</sourcerecordid><originalsourceid>FETCH-LOGICAL-c340t-b41907a2aaea3ea49227b23fd9e70651a0f240c8e4112c539da27192b1ce84853</originalsourceid><addsrcrecordid>eNp1kE1r3DAQhkVpaDZprz0WnXrzdkaSP5Rb2HzC0ixhexayPG4VvNZGsgP772uzS3rqaYbheV-Yh7GvCEsEKH68DLVfCgBYClT6A1sg6DyrcoUf2QJAiCxHLc_ZRUovE6WVLD6xc0RAiVgsWPNMv8fODj70PLR8M63U0cA3MTSjm89XfPuH-M8Qd7bjz5T2oU_Eh8A3FIcx1ses7Ru-OrjOu4l6b7nxiWyiz-ystV2iL6d5yX7d3W5XD9n66f5xdb3OnFQwZLVCDaUV1pKVZJUWoqyFbBtNJRQ5WmiFAleRQhQul7qxokQtanRUqSqXl-z7sXcfw-tIaTA7nxx1ne0pjMmUQkJVqGICl0fQxZBSpNbso9_ZeDAIZvZqZq9m9mpmr1Pg26l5rHfU_MNPIiegOgI0_ffmKZrkPPWOGh_JDaYJ_n_dfwHln4cO</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72308646</pqid></control><display><type>article</type><title>Regulation of Platelet Production: The Normal Response to Perturbation and Cyclical Platelet Disease</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>SANTILLÁN, MOISÉS ; MAHAFFY, JOSEPH M ; BÉLAIR, JACQUES ; MACKEY, MICHAEL C</creator><creatorcontrib>SANTILLÁN, MOISÉS ; MAHAFFY, JOSEPH M ; BÉLAIR, JACQUES ; MACKEY, MICHAEL C</creatorcontrib><description>An age-structured model for the regulation of platelet production is developed, and compared with both normal and pathological platelet production. We consider the role of thrombopoietin (TPO) in this process, how TPO affects the transition between megakaryocytes of various ploidy classes, and their individual contributions to platelet production. After the estimation of the relevant parameters of the model from both in vivo and in vitro data, we use the model to numerically reproduce the normal human response to a bolus injection of TPO. We further show that our model reproduces the dynamic characteristics of autoimmune cyclical thromobocytopenia if the rate of platelet destruction in the circulation is elevated to more than twice the normal value.</description><identifier>ISSN: 0022-5193</identifier><identifier>EISSN: 1095-8541</identifier><identifier>DOI: 10.1006/jtbi.2000.2149</identifier><identifier>PMID: 11013116</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Aging - physiology ; Blood Platelets - physiology ; Hematopoiesis - physiology ; Humans ; Injections ; Megakaryocytes - cytology ; Models, Biological ; Platelet Count ; Ploidies ; Thrombocytopenia - blood ; Thrombopoietin - pharmacology ; Thrombopoietin - physiology</subject><ispartof>Journal of theoretical biology, 2000-10, Vol.206 (4), p.585-603</ispartof><rights>2000 Academic Press</rights><rights>Copyright 2000 Academic Press.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c340t-b41907a2aaea3ea49227b23fd9e70651a0f240c8e4112c539da27192b1ce84853</citedby><cites>FETCH-LOGICAL-c340t-b41907a2aaea3ea49227b23fd9e70651a0f240c8e4112c539da27192b1ce84853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1006/jtbi.2000.2149$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11013116$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SANTILLÁN, MOISÉS</creatorcontrib><creatorcontrib>MAHAFFY, JOSEPH M</creatorcontrib><creatorcontrib>BÉLAIR, JACQUES</creatorcontrib><creatorcontrib>MACKEY, MICHAEL C</creatorcontrib><title>Regulation of Platelet Production: The Normal Response to Perturbation and Cyclical Platelet Disease</title><title>Journal of theoretical biology</title><addtitle>J Theor Biol</addtitle><description>An age-structured model for the regulation of platelet production is developed, and compared with both normal and pathological platelet production. We consider the role of thrombopoietin (TPO) in this process, how TPO affects the transition between megakaryocytes of various ploidy classes, and their individual contributions to platelet production. After the estimation of the relevant parameters of the model from both in vivo and in vitro data, we use the model to numerically reproduce the normal human response to a bolus injection of TPO. We further show that our model reproduces the dynamic characteristics of autoimmune cyclical thromobocytopenia if the rate of platelet destruction in the circulation is elevated to more than twice the normal value.</description><subject>Aging - physiology</subject><subject>Blood Platelets - physiology</subject><subject>Hematopoiesis - physiology</subject><subject>Humans</subject><subject>Injections</subject><subject>Megakaryocytes - cytology</subject><subject>Models, Biological</subject><subject>Platelet Count</subject><subject>Ploidies</subject><subject>Thrombocytopenia - blood</subject><subject>Thrombopoietin - pharmacology</subject><subject>Thrombopoietin - physiology</subject><issn>0022-5193</issn><issn>1095-8541</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1r3DAQhkVpaDZprz0WnXrzdkaSP5Rb2HzC0ixhexayPG4VvNZGsgP772uzS3rqaYbheV-Yh7GvCEsEKH68DLVfCgBYClT6A1sg6DyrcoUf2QJAiCxHLc_ZRUovE6WVLD6xc0RAiVgsWPNMv8fODj70PLR8M63U0cA3MTSjm89XfPuH-M8Qd7bjz5T2oU_Eh8A3FIcx1ses7Ru-OrjOu4l6b7nxiWyiz-ystV2iL6d5yX7d3W5XD9n66f5xdb3OnFQwZLVCDaUV1pKVZJUWoqyFbBtNJRQ5WmiFAleRQhQul7qxokQtanRUqSqXl-z7sXcfw-tIaTA7nxx1ne0pjMmUQkJVqGICl0fQxZBSpNbso9_ZeDAIZvZqZq9m9mpmr1Pg26l5rHfU_MNPIiegOgI0_ffmKZrkPPWOGh_JDaYJ_n_dfwHln4cO</recordid><startdate>20001021</startdate><enddate>20001021</enddate><creator>SANTILLÁN, MOISÉS</creator><creator>MAHAFFY, JOSEPH M</creator><creator>BÉLAIR, JACQUES</creator><creator>MACKEY, MICHAEL C</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20001021</creationdate><title>Regulation of Platelet Production: The Normal Response to Perturbation and Cyclical Platelet Disease</title><author>SANTILLÁN, MOISÉS ; MAHAFFY, JOSEPH M ; BÉLAIR, JACQUES ; MACKEY, MICHAEL C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c340t-b41907a2aaea3ea49227b23fd9e70651a0f240c8e4112c539da27192b1ce84853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Aging - physiology</topic><topic>Blood Platelets - physiology</topic><topic>Hematopoiesis - physiology</topic><topic>Humans</topic><topic>Injections</topic><topic>Megakaryocytes - cytology</topic><topic>Models, Biological</topic><topic>Platelet Count</topic><topic>Ploidies</topic><topic>Thrombocytopenia - blood</topic><topic>Thrombopoietin - pharmacology</topic><topic>Thrombopoietin - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SANTILLÁN, MOISÉS</creatorcontrib><creatorcontrib>MAHAFFY, JOSEPH M</creatorcontrib><creatorcontrib>BÉLAIR, JACQUES</creatorcontrib><creatorcontrib>MACKEY, MICHAEL C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of theoretical biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SANTILLÁN, MOISÉS</au><au>MAHAFFY, JOSEPH M</au><au>BÉLAIR, JACQUES</au><au>MACKEY, MICHAEL C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regulation of Platelet Production: The Normal Response to Perturbation and Cyclical Platelet Disease</atitle><jtitle>Journal of theoretical biology</jtitle><addtitle>J Theor Biol</addtitle><date>2000-10-21</date><risdate>2000</risdate><volume>206</volume><issue>4</issue><spage>585</spage><epage>603</epage><pages>585-603</pages><issn>0022-5193</issn><eissn>1095-8541</eissn><abstract>An age-structured model for the regulation of platelet production is developed, and compared with both normal and pathological platelet production. We consider the role of thrombopoietin (TPO) in this process, how TPO affects the transition between megakaryocytes of various ploidy classes, and their individual contributions to platelet production. After the estimation of the relevant parameters of the model from both in vivo and in vitro data, we use the model to numerically reproduce the normal human response to a bolus injection of TPO. We further show that our model reproduces the dynamic characteristics of autoimmune cyclical thromobocytopenia if the rate of platelet destruction in the circulation is elevated to more than twice the normal value.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>11013116</pmid><doi>10.1006/jtbi.2000.2149</doi><tpages>19</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-5193 |
| ispartof | Journal of theoretical biology, 2000-10, Vol.206 (4), p.585-603 |
| issn | 0022-5193 1095-8541 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72308646 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Aging - physiology Blood Platelets - physiology Hematopoiesis - physiology Humans Injections Megakaryocytes - cytology Models, Biological Platelet Count Ploidies Thrombocytopenia - blood Thrombopoietin - pharmacology Thrombopoietin - physiology |
| title | Regulation of Platelet Production: The Normal Response to Perturbation and Cyclical Platelet Disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T09%3A58%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Regulation%20of%20Platelet%20Production:%20The%20Normal%20Response%20to%20Perturbation%20and%20Cyclical%20Platelet%20Disease&rft.jtitle=Journal%20of%20theoretical%20biology&rft.au=SANTILL%C3%81N,%20MOIS%C3%89S&rft.date=2000-10-21&rft.volume=206&rft.issue=4&rft.spage=585&rft.epage=603&rft.pages=585-603&rft.issn=0022-5193&rft.eissn=1095-8541&rft_id=info:doi/10.1006/jtbi.2000.2149&rft_dat=%3Cproquest_cross%3E72308646%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=72308646&rft_id=info:pmid/11013116&rft_els_id=S0022519300921490&rfr_iscdi=true |