Recombinant FVIIa (NovoSeven) continuous infusion and total hip replacement in patients with haemophilia and high titre of inhibitors to FVIII: experience of two cases

In this report we describe our experience of total hip replacement in two patients with severe haemophilia A and high titres of inhibitors to FVIII. We used rFVIIa replacement therapy by continuous infusion to perform the surgery. The total amount of rFVIIa used in these two patients was very simila...

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Veröffentlicht in:	Haemophilia : the official journal of the World Federation of Hemophilia 2000-09, Vol.6 (5), p.581-583
Hauptverfasser:	Tagariello, G, De Biasi, E, Gajo, G B, Risato, R, Radossi, P, Davoli, P G, Traldi, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Arthroplasty, Replacement, Hip - adverse effects Arthroplasty, Replacement, Hip - methods Blood Loss, Surgical - prevention & control continuous infusion Factor VIIa - administration & dosage Factor VIII - adverse effects Factor VIII - immunology haemophilia Hemophilia A - complications Hemophilia A - drug therapy Hemophilia A - surgery Hemostasis - drug effects Humans Infusions, Parenteral inhibitors Isoantibodies - blood Male Recombinant Proteins - administration & dosage rFVIIa Sodium Chloride - administration & dosage Tranexamic Acid - administration & dosage
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