Methicillin-resistant Staphylococcus aureus sepsis associated with the transfusion of contaminated platelets: a case report
BACKGROUND: Platelet transfusion‐associated sepsis is usually due to donor skin flora introduced into the unit during phlebotomy. An unusual case of a platelet component contaminated with methicillin‐resistant Staphylococcus aureus (MRSA) is reported. CASE REPORT: A 54‐year‐old man, terminally ill w...
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| Veröffentlicht in: | Transfusion (Philadelphia, Pa.) Pa.), 2001-11, Vol.41 (11), p.1426-1430 |
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| container_title | Transfusion (Philadelphia, Pa.) |
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| creator | Sapatnekar, Suneeti Wood, Erica M. Miller, John P. Jacobs, Michael R. Arduino, Matthew J. McAllister, Sigrid K. Kellum, Molly E. Roth, Virginia Yomtovian, Roslyn |
| description | BACKGROUND: Platelet transfusion‐associated sepsis is usually due to donor skin flora introduced into the unit during phlebotomy. An unusual case of a platelet component contaminated with methicillin‐resistant Staphylococcus aureus (MRSA) is reported.
CASE REPORT: A 54‐year‐old man, terminally ill with progressive non‐Hodgkin's lymphoma, developed fever and hypotension during a platelet transfusion. He was receiving multiple antibiotics, including vancomycin. Blood cultures taken soon after transfusion were negative. An aliquot taken from the platelet pool grew MRSA at a count of 1.6 × 108 CFUs per mL. One of the individual bags constituting the pool showed MRSA at a count of 5.1 × 108 CFUs per mL. The patient died soon after the platelet transfusion. This case was reported to the FDA and submitted to the BaCon Study. The identity of the isolate and its methicillin resistance were confirmed by the CDC as part of the BaCon Study protocol. The source of contamination of the implicated unit could not be established with certainty.
CONCLUSION: The emergence of antimicrobial‐resistant organisms poses additional challenges for the diagnosis and treatment of transfusion‐associated sepsis. Measures to prevent or intercept the transfusion of contaminated platelets should be developed. |
| doi_str_mv | 10.1046/j.1537-2995.2001.41111426.x |
| format | Article |
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CASE REPORT: A 54‐year‐old man, terminally ill with progressive non‐Hodgkin's lymphoma, developed fever and hypotension during a platelet transfusion. He was receiving multiple antibiotics, including vancomycin. Blood cultures taken soon after transfusion were negative. An aliquot taken from the platelet pool grew MRSA at a count of 1.6 × 108 CFUs per mL. One of the individual bags constituting the pool showed MRSA at a count of 5.1 × 108 CFUs per mL. The patient died soon after the platelet transfusion. This case was reported to the FDA and submitted to the BaCon Study. The identity of the isolate and its methicillin resistance were confirmed by the CDC as part of the BaCon Study protocol. The source of contamination of the implicated unit could not be established with certainty.
CONCLUSION: The emergence of antimicrobial‐resistant organisms poses additional challenges for the diagnosis and treatment of transfusion‐associated sepsis. Measures to prevent or intercept the transfusion of contaminated platelets should be developed.</description><identifier>ISSN: 0041-1132</identifier><identifier>EISSN: 1537-2995</identifier><identifier>DOI: 10.1046/j.1537-2995.2001.41111426.x</identifier><identifier>PMID: 11724990</identifier><identifier>CODEN: TRANAT</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Inc</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Bacterial diseases ; Bacterial sepsis ; Biological and medical sciences ; Blood Platelets - microbiology ; Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis ; Centers for Disease Control and Prevention (U.S.) ; Colony Count, Microbial ; Fatal Outcome ; Human bacterial diseases ; Humans ; Infectious diseases ; Male ; Medical sciences ; Methicillin Resistance ; Middle Aged ; MRSA = methicillin-resistant Staphylococcus aureus: PFGE = pulsed-field gel electrophoresis ; Platelet Transfusion - adverse effects ; Staphylococcal Infections - etiology ; Staphylococcal Infections - microbiology ; Staphylococcal Infections - transmission ; Staphylococcus aureus - physiology ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy ; United States</subject><ispartof>Transfusion (Philadelphia, Pa.), 2001-11, Vol.41 (11), p.1426-1430</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4466-72c41077c350a549d88ae3d164944463bf9726f54c3f7950577a149e95b1abc3</citedby><cites>FETCH-LOGICAL-c4466-72c41077c350a549d88ae3d164944463bf9726f54c3f7950577a149e95b1abc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1537-2995.2001.41111426.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1537-2995.2001.41111426.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14143591$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11724990$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sapatnekar, Suneeti</creatorcontrib><creatorcontrib>Wood, Erica M.</creatorcontrib><creatorcontrib>Miller, John P.</creatorcontrib><creatorcontrib>Jacobs, Michael R.</creatorcontrib><creatorcontrib>Arduino, Matthew J.</creatorcontrib><creatorcontrib>McAllister, Sigrid K.</creatorcontrib><creatorcontrib>Kellum, Molly E.</creatorcontrib><creatorcontrib>Roth, Virginia</creatorcontrib><creatorcontrib>Yomtovian, Roslyn</creatorcontrib><title>Methicillin-resistant Staphylococcus aureus sepsis associated with the transfusion of contaminated platelets: a case report</title><title>Transfusion (Philadelphia, Pa.)</title><addtitle>Transfusion</addtitle><description>BACKGROUND: Platelet transfusion‐associated sepsis is usually due to donor skin flora introduced into the unit during phlebotomy. An unusual case of a platelet component contaminated with methicillin‐resistant Staphylococcus aureus (MRSA) is reported.
CASE REPORT: A 54‐year‐old man, terminally ill with progressive non‐Hodgkin's lymphoma, developed fever and hypotension during a platelet transfusion. He was receiving multiple antibiotics, including vancomycin. Blood cultures taken soon after transfusion were negative. An aliquot taken from the platelet pool grew MRSA at a count of 1.6 × 108 CFUs per mL. One of the individual bags constituting the pool showed MRSA at a count of 5.1 × 108 CFUs per mL. The patient died soon after the platelet transfusion. This case was reported to the FDA and submitted to the BaCon Study. The identity of the isolate and its methicillin resistance were confirmed by the CDC as part of the BaCon Study protocol. The source of contamination of the implicated unit could not be established with certainty.
CONCLUSION: The emergence of antimicrobial‐resistant organisms poses additional challenges for the diagnosis and treatment of transfusion‐associated sepsis. Measures to prevent or intercept the transfusion of contaminated platelets should be developed.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Bacterial diseases</subject><subject>Bacterial sepsis</subject><subject>Biological and medical sciences</subject><subject>Blood Platelets - microbiology</subject><subject>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</subject><subject>Centers for Disease Control and Prevention (U.S.)</subject><subject>Colony Count, Microbial</subject><subject>Fatal Outcome</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methicillin Resistance</subject><subject>Middle Aged</subject><subject>MRSA = methicillin-resistant Staphylococcus aureus: PFGE = pulsed-field gel electrophoresis</subject><subject>Platelet Transfusion - adverse effects</subject><subject>Staphylococcal Infections - etiology</subject><subject>Staphylococcal Infections - microbiology</subject><subject>Staphylococcal Infections - transmission</subject><subject>Staphylococcus aureus - physiology</subject><subject>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><subject>United States</subject><issn>0041-1132</issn><issn>1537-2995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkV9vUyEYh4nRuDr9CobE6N2p_D0MvTLVbZqpUZvoHaGUk1Lp4cjLydrsy0ttt13LzS-E5_1BHhB6QcmUEtG-Xk-p5KphWsspI4ROBa1LsHa6fYAmd2cP0YQQQRtKOTtBTwDWhBCmCX2MTihVTGhNJujmsy-r4EKMoW-yhwDF9gX_KHZY7WJyybkRsB2zrwF-qAC2AMkFW_wSX4eywmXlccm2h26EkHqcOuxSX-wm9P-gIdaIvsAbbLGz4HH2Q8rlKXrU2Qj-2TFP0fz8w3x22Vx9vfg4e3fVOCHatlHMCUqUclwSK4Venp1Zz5e0FVpUgC86rVjbSeF4p7QkUilLhfZaLqhdOH6KXh1qh5z-jB6K2QRwPkbb-zSCUYyTVhNZwbcH0OUEkH1nhhw2Nu8MJWav3qzNXq_Z6zV79eZWvdnW6efHa8bFxi_vZ4-uK_DyCFhwNnbVmAtwzwkquNS0cu8P3HWIfvc_bzDz7-e3u1rTHGrql_rtXY3Nv02ruJLm55cLM5v9mrdMfzOf-F_td7Hz</recordid><startdate>200111</startdate><enddate>200111</enddate><creator>Sapatnekar, Suneeti</creator><creator>Wood, Erica M.</creator><creator>Miller, John P.</creator><creator>Jacobs, Michael R.</creator><creator>Arduino, Matthew J.</creator><creator>McAllister, Sigrid K.</creator><creator>Kellum, Molly E.</creator><creator>Roth, Virginia</creator><creator>Yomtovian, Roslyn</creator><general>Blackwell Science Inc</general><general>Blackwell Publishing</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200111</creationdate><title>Methicillin-resistant Staphylococcus aureus sepsis associated with the transfusion of contaminated platelets: a case report</title><author>Sapatnekar, Suneeti ; Wood, Erica M. ; Miller, John P. ; Jacobs, Michael R. ; Arduino, Matthew J. ; McAllister, Sigrid K. ; Kellum, Molly E. ; Roth, Virginia ; Yomtovian, Roslyn</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4466-72c41077c350a549d88ae3d164944463bf9726f54c3f7950577a149e95b1abc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Bacterial diseases</topic><topic>Bacterial sepsis</topic><topic>Biological and medical sciences</topic><topic>Blood Platelets - microbiology</topic><topic>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</topic><topic>Centers for Disease Control and Prevention (U.S.)</topic><topic>Colony Count, Microbial</topic><topic>Fatal Outcome</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methicillin Resistance</topic><topic>Middle Aged</topic><topic>MRSA = methicillin-resistant Staphylococcus aureus: PFGE = pulsed-field gel electrophoresis</topic><topic>Platelet Transfusion - adverse effects</topic><topic>Staphylococcal Infections - etiology</topic><topic>Staphylococcal Infections - microbiology</topic><topic>Staphylococcal Infections - transmission</topic><topic>Staphylococcus aureus - physiology</topic><topic>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</topic><topic>United States</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sapatnekar, Suneeti</creatorcontrib><creatorcontrib>Wood, Erica M.</creatorcontrib><creatorcontrib>Miller, John P.</creatorcontrib><creatorcontrib>Jacobs, Michael R.</creatorcontrib><creatorcontrib>Arduino, Matthew J.</creatorcontrib><creatorcontrib>McAllister, Sigrid K.</creatorcontrib><creatorcontrib>Kellum, Molly E.</creatorcontrib><creatorcontrib>Roth, Virginia</creatorcontrib><creatorcontrib>Yomtovian, Roslyn</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transfusion (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sapatnekar, Suneeti</au><au>Wood, Erica M.</au><au>Miller, John P.</au><au>Jacobs, Michael R.</au><au>Arduino, Matthew J.</au><au>McAllister, Sigrid K.</au><au>Kellum, Molly E.</au><au>Roth, Virginia</au><au>Yomtovian, Roslyn</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Methicillin-resistant Staphylococcus aureus sepsis associated with the transfusion of contaminated platelets: a case report</atitle><jtitle>Transfusion (Philadelphia, Pa.)</jtitle><addtitle>Transfusion</addtitle><date>2001-11</date><risdate>2001</risdate><volume>41</volume><issue>11</issue><spage>1426</spage><epage>1430</epage><pages>1426-1430</pages><issn>0041-1132</issn><eissn>1537-2995</eissn><coden>TRANAT</coden><abstract>BACKGROUND: Platelet transfusion‐associated sepsis is usually due to donor skin flora introduced into the unit during phlebotomy. An unusual case of a platelet component contaminated with methicillin‐resistant Staphylococcus aureus (MRSA) is reported.
CASE REPORT: A 54‐year‐old man, terminally ill with progressive non‐Hodgkin's lymphoma, developed fever and hypotension during a platelet transfusion. He was receiving multiple antibiotics, including vancomycin. Blood cultures taken soon after transfusion were negative. An aliquot taken from the platelet pool grew MRSA at a count of 1.6 × 108 CFUs per mL. One of the individual bags constituting the pool showed MRSA at a count of 5.1 × 108 CFUs per mL. The patient died soon after the platelet transfusion. This case was reported to the FDA and submitted to the BaCon Study. The identity of the isolate and its methicillin resistance were confirmed by the CDC as part of the BaCon Study protocol. The source of contamination of the implicated unit could not be established with certainty.
CONCLUSION: The emergence of antimicrobial‐resistant organisms poses additional challenges for the diagnosis and treatment of transfusion‐associated sepsis. Measures to prevent or intercept the transfusion of contaminated platelets should be developed.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Inc</pub><pmid>11724990</pmid><doi>10.1046/j.1537-2995.2001.41111426.x</doi><tpages>5</tpages></addata></record> |
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| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Bacterial diseases Bacterial sepsis Biological and medical sciences Blood Platelets - microbiology Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Centers for Disease Control and Prevention (U.S.) Colony Count, Microbial Fatal Outcome Human bacterial diseases Humans Infectious diseases Male Medical sciences Methicillin Resistance Middle Aged MRSA = methicillin-resistant Staphylococcus aureus: PFGE = pulsed-field gel electrophoresis Platelet Transfusion - adverse effects Staphylococcal Infections - etiology Staphylococcal Infections - microbiology Staphylococcal Infections - transmission Staphylococcus aureus - physiology Transfusions. Complications. Transfusion reactions. Cell and gene therapy United States |
| title | Methicillin-resistant Staphylococcus aureus sepsis associated with the transfusion of contaminated platelets: a case report |
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