Factors affecting acoustically triggered release of drugs from polymeric micelles

A custom ultrasonic exposure chamber with real-time fluorescence detection was used to measure acoustically-triggered drug release from Pluronic P-105 micelles under continuous wave (CW) or pulsed ultrasound in the frequency range of 20 to 90 kHz. The measurements were based on the decrease in fluor...

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Veröffentlicht in:	Journal of controlled release 2000-10, Vol.69 (1), p.43-52
Hauptverfasser:	Husseini, Ghaleb A, Myrup, Gregg D, Pitt, William G, Christensen, Douglas A, Rapoport, Natalya Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - administration & dosage Antibiotics, Antineoplastic - chemistry Antineoplastic agents Biological and medical sciences Chemotherapy Daunorubicin - administration & dosage Daunorubicin - analogs & derivatives Daunorubicin - chemistry Doxorubicin Doxorubicin - administration & dosage Doxorubicin - chemistry Drug Compounding Drug delivery Excipients Free Radicals General pharmacology Medical sciences Micelles Micellization Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Pluronic Polymeric micelles Polymers - chemistry Ruboxyl Spectrometry, Fluorescence Triggered release Ultrasonics Ultrasound
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