Interaction of commonly used emollients with photochemotherapy
Background/Aim: Even though emollients are commonly used in combination with photochemotherapy, we still lack guidance for the selection of the appropriate emollient to be used in combination with photochemotherapy. The purpose of our study was to determine the interaction of commonly used emollient...
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| Veröffentlicht in: | Photodermatology, photoimmunology & photomedicine photoimmunology & photomedicine, 2000-08, Vol.16 (4), p.156-160 |
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| container_title | Photodermatology, photoimmunology & photomedicine |
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| creator | Boyvat, Ayşe Erdi, Hatice Birol, Ahu Gůrgey, Erbak |
| description | Background/Aim: Even though emollients are commonly used in combination with photochemotherapy, we still lack guidance for the selection of the appropriate emollient to be used in combination with photochemotherapy. The purpose of our study was to determine the interaction of commonly used emollients with photochemotherapy.
Methods: The study was carried on 75 healthy volunteers. In order to assess the effects of five different emollients – white petrolatum, 3% salicylic acid in white petrolatum, Balmandol, Decubal and Urederm hydro – the subjects were divided into five groups. Minimal phototoxic dose (MPD) was determined by irradiating two rows of six circular test fields on the back of the subjects with increasing doses of UVA. One of the emollients listed above was applied to the skin under the upper rows alternatively, whereas the lower rows served as control.
Results: Application of Urederm hydro and Decubal before exposure to UVA resulted in a statistically significant decrease in the MPD in all subjects. Even though application of white petrolatum and white petrolatum containing 3% salicylic acid decreased the MPD in most of the subjects and Balmandol application slightly increased the MPD, the results did not reach statistical significance.
Conclusions: According to our findings, it is probable that the total dose of UVA needed to cause clearing of psoriasis would be decreased by application of Urederm hydro and Decubal prior to photochemotherapy. We noted a slight photoprotective effect of Balmandol in the UVA range, but this finding has to be further studied. Clinical studies are needed to clarify the effects of these emollients on the course and outcome of photochemotherapy. |
| doi_str_mv | 10.1034/j.1600-0781.2000.160402.x |
| format | Article |
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Methods: The study was carried on 75 healthy volunteers. In order to assess the effects of five different emollients – white petrolatum, 3% salicylic acid in white petrolatum, Balmandol, Decubal and Urederm hydro – the subjects were divided into five groups. Minimal phototoxic dose (MPD) was determined by irradiating two rows of six circular test fields on the back of the subjects with increasing doses of UVA. One of the emollients listed above was applied to the skin under the upper rows alternatively, whereas the lower rows served as control.
Results: Application of Urederm hydro and Decubal before exposure to UVA resulted in a statistically significant decrease in the MPD in all subjects. Even though application of white petrolatum and white petrolatum containing 3% salicylic acid decreased the MPD in most of the subjects and Balmandol application slightly increased the MPD, the results did not reach statistical significance.
Conclusions: According to our findings, it is probable that the total dose of UVA needed to cause clearing of psoriasis would be decreased by application of Urederm hydro and Decubal prior to photochemotherapy. We noted a slight photoprotective effect of Balmandol in the UVA range, but this finding has to be further studied. Clinical studies are needed to clarify the effects of these emollients on the course and outcome of photochemotherapy.</description><identifier>ISSN: 0905-4383</identifier><identifier>EISSN: 1600-0781</identifier><identifier>DOI: 10.1034/j.1600-0781.2000.160402.x</identifier><identifier>PMID: 11019939</identifier><language>eng</language><publisher>Copenhagen: Munksgaard International Publishers</publisher><subject>Analysis of Variance ; Balmandol ; Biological and medical sciences ; Decubal ; Diseases of the skin. Cosmetics ; emollients ; Emollients - pharmacology ; Emollients - therapeutic use ; Erythema ; Female ; Humans ; Male ; Medical sciences ; Photochemotherapy ; photochemotherapy, emollients ; Psoriasis - drug therapy ; PUVA Therapy ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; salicylic acid ; Skin Diseases - drug therapy ; Statistics, Nonparametric ; white petrolatum</subject><ispartof>Photodermatology, photoimmunology & photomedicine, 2000-08, Vol.16 (4), p.156-160</ispartof><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4382-1fd66cacf0c7f5cf0967b721e165151ad181715473243a30bbf88e764e7c743f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1034%2Fj.1600-0781.2000.160402.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1034%2Fj.1600-0781.2000.160402.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1463554$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11019939$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boyvat, Ayşe</creatorcontrib><creatorcontrib>Erdi, Hatice</creatorcontrib><creatorcontrib>Birol, Ahu</creatorcontrib><creatorcontrib>Gůrgey, Erbak</creatorcontrib><title>Interaction of commonly used emollients with photochemotherapy</title><title>Photodermatology, photoimmunology & photomedicine</title><addtitle>Photodermatol Photoimmunol Photomed</addtitle><description>Background/Aim: Even though emollients are commonly used in combination with photochemotherapy, we still lack guidance for the selection of the appropriate emollient to be used in combination with photochemotherapy. The purpose of our study was to determine the interaction of commonly used emollients with photochemotherapy.
Methods: The study was carried on 75 healthy volunteers. In order to assess the effects of five different emollients – white petrolatum, 3% salicylic acid in white petrolatum, Balmandol, Decubal and Urederm hydro – the subjects were divided into five groups. Minimal phototoxic dose (MPD) was determined by irradiating two rows of six circular test fields on the back of the subjects with increasing doses of UVA. One of the emollients listed above was applied to the skin under the upper rows alternatively, whereas the lower rows served as control.
Results: Application of Urederm hydro and Decubal before exposure to UVA resulted in a statistically significant decrease in the MPD in all subjects. Even though application of white petrolatum and white petrolatum containing 3% salicylic acid decreased the MPD in most of the subjects and Balmandol application slightly increased the MPD, the results did not reach statistical significance.
Conclusions: According to our findings, it is probable that the total dose of UVA needed to cause clearing of psoriasis would be decreased by application of Urederm hydro and Decubal prior to photochemotherapy. We noted a slight photoprotective effect of Balmandol in the UVA range, but this finding has to be further studied. Clinical studies are needed to clarify the effects of these emollients on the course and outcome of photochemotherapy.</description><subject>Analysis of Variance</subject><subject>Balmandol</subject><subject>Biological and medical sciences</subject><subject>Decubal</subject><subject>Diseases of the skin. Cosmetics</subject><subject>emollients</subject><subject>Emollients - pharmacology</subject><subject>Emollients - therapeutic use</subject><subject>Erythema</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Photochemotherapy</subject><subject>photochemotherapy, emollients</subject><subject>Psoriasis - drug therapy</subject><subject>PUVA Therapy</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>salicylic acid</subject><subject>Skin Diseases - drug therapy</subject><subject>Statistics, Nonparametric</subject><subject>white petrolatum</subject><issn>0905-4383</issn><issn>1600-0781</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkF1r2zAUhsVoWbN0f2F4UHrn7Bzry74Z9GttIG1z0bHdCUWRiDPbSi2HJv9-Mg7Nba_EkZ73PeIh5DvCBIGyH-sJCoAUZI6TDAD6kUE22X0io_eXEzKCAnjKaE7PyJcQ1pFkDPAzOUMELApajMjPadPZVpuu9E3iXWJ8Xfum2ifbYJeJrX1VlbbpQvJWdqtks_KdN6t43a1iarM_J6dOV8F-PZxj8vvX3cvNQzp7vp_eXM1SE9dnKbqlEEYbB0Y6Ho9CyIXM0KLgyFEvMUeJnEmaMaopLBYuz60UzEojGXV0TC6H3k3rX7c2dKoug7FVpRvrt0HJjAKnMT8mxQCa1ofQWqc2bVnrdq8QVC9PrVWvSPWKVC9PDfLULma_HZZsF7VdHpMHWxG4OAA6GF25VjemDEeOCco5i9jVgL2Vld1__ANq_jCfD0PsSIeOMnR2996h239KSCq5-vN0r66LRzG7_XutHul_KM-ZzQ</recordid><startdate>200008</startdate><enddate>200008</enddate><creator>Boyvat, Ayşe</creator><creator>Erdi, Hatice</creator><creator>Birol, Ahu</creator><creator>Gůrgey, Erbak</creator><general>Munksgaard International Publishers</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200008</creationdate><title>Interaction of commonly used emollients with photochemotherapy</title><author>Boyvat, Ayşe ; Erdi, Hatice ; Birol, Ahu ; Gůrgey, Erbak</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4382-1fd66cacf0c7f5cf0967b721e165151ad181715473243a30bbf88e764e7c743f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Analysis of Variance</topic><topic>Balmandol</topic><topic>Biological and medical sciences</topic><topic>Decubal</topic><topic>Diseases of the skin. Cosmetics</topic><topic>emollients</topic><topic>Emollients - pharmacology</topic><topic>Emollients - therapeutic use</topic><topic>Erythema</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Photochemotherapy</topic><topic>photochemotherapy, emollients</topic><topic>Psoriasis - drug therapy</topic><topic>PUVA Therapy</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>salicylic acid</topic><topic>Skin Diseases - drug therapy</topic><topic>Statistics, Nonparametric</topic><topic>white petrolatum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boyvat, Ayşe</creatorcontrib><creatorcontrib>Erdi, Hatice</creatorcontrib><creatorcontrib>Birol, Ahu</creatorcontrib><creatorcontrib>Gůrgey, Erbak</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Photodermatology, photoimmunology & photomedicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boyvat, Ayşe</au><au>Erdi, Hatice</au><au>Birol, Ahu</au><au>Gůrgey, Erbak</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interaction of commonly used emollients with photochemotherapy</atitle><jtitle>Photodermatology, photoimmunology & photomedicine</jtitle><addtitle>Photodermatol Photoimmunol Photomed</addtitle><date>2000-08</date><risdate>2000</risdate><volume>16</volume><issue>4</issue><spage>156</spage><epage>160</epage><pages>156-160</pages><issn>0905-4383</issn><eissn>1600-0781</eissn><abstract>Background/Aim: Even though emollients are commonly used in combination with photochemotherapy, we still lack guidance for the selection of the appropriate emollient to be used in combination with photochemotherapy. The purpose of our study was to determine the interaction of commonly used emollients with photochemotherapy.
Methods: The study was carried on 75 healthy volunteers. In order to assess the effects of five different emollients – white petrolatum, 3% salicylic acid in white petrolatum, Balmandol, Decubal and Urederm hydro – the subjects were divided into five groups. Minimal phototoxic dose (MPD) was determined by irradiating two rows of six circular test fields on the back of the subjects with increasing doses of UVA. One of the emollients listed above was applied to the skin under the upper rows alternatively, whereas the lower rows served as control.
Results: Application of Urederm hydro and Decubal before exposure to UVA resulted in a statistically significant decrease in the MPD in all subjects. Even though application of white petrolatum and white petrolatum containing 3% salicylic acid decreased the MPD in most of the subjects and Balmandol application slightly increased the MPD, the results did not reach statistical significance.
Conclusions: According to our findings, it is probable that the total dose of UVA needed to cause clearing of psoriasis would be decreased by application of Urederm hydro and Decubal prior to photochemotherapy. We noted a slight photoprotective effect of Balmandol in the UVA range, but this finding has to be further studied. Clinical studies are needed to clarify the effects of these emollients on the course and outcome of photochemotherapy.</abstract><cop>Copenhagen</cop><pub>Munksgaard International Publishers</pub><pmid>11019939</pmid><doi>10.1034/j.1600-0781.2000.160402.x</doi><tpages>5</tpages></addata></record> |
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| source | Wiley-Blackwell Journals; MEDLINE |
| subjects | Analysis of Variance Balmandol Biological and medical sciences Decubal Diseases of the skin. Cosmetics emollients Emollients - pharmacology Emollients - therapeutic use Erythema Female Humans Male Medical sciences Photochemotherapy photochemotherapy, emollients Psoriasis - drug therapy PUVA Therapy Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) salicylic acid Skin Diseases - drug therapy Statistics, Nonparametric white petrolatum |
| title | Interaction of commonly used emollients with photochemotherapy |
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