Introduction of Recirculatory Analysis into Portal and Systemic Concentration Difference Method
Recirculatory analysis was introduced into the portal and systemic concentration difference method with double dosing (PS-DD method), which is an evaluation system for the local intestinal and hepatic first-pass effect. 5-Fluorouracil (5-FU) and cephalexin (CEX) were selected as model drugs. A new r...
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 2001, Vol.24(11), pp.1298-1304 |
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| container_title | Biological & pharmaceutical bulletin |
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| creator | UEDA, Shinya YAMAOKA, Kiyoshi SAWAI, Yoneichi NAKAGAWA, Terumichi |
| description | Recirculatory analysis was introduced into the portal and systemic concentration difference method with double dosing (PS-DD method), which is an evaluation system for the local intestinal and hepatic first-pass effect. 5-Fluorouracil (5-FU) and cephalexin (CEX) were selected as model drugs. A new recirculatory system was constructed to predict the time courses of a drug concentration in the systemic and portal bloods. Bioavailability (F), local absorption ratio (Fa), hepatic recovery ratio (FH), and local mean absorption time (¯ta) estimated by recirculatory analysis were close to those calculated by moment analysis with numerical integration. Using recirculatory analysis, the sampling period was considerably shortened and the sampling number was also reduced, which demonstrates that recirculatory analysis is useful in PS-DD method. |
| doi_str_mv | 10.1248/bpb.24.1298 |
| format | Article |
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A new recirculatory system was constructed to predict the time courses of a drug concentration in the systemic and portal bloods. Bioavailability (F), local absorption ratio (Fa), hepatic recovery ratio (FH), and local mean absorption time (¯ta) estimated by recirculatory analysis were close to those calculated by moment analysis with numerical integration. Using recirculatory analysis, the sampling period was considerably shortened and the sampling number was also reduced, which demonstrates that recirculatory analysis is useful in PS-DD method.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.24.1298</identifier><identifier>PMID: 11725968</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>Administration, Oral ; Animals ; Biological and medical sciences ; Biological Availability ; Cephalexin - blood ; Cephalexin - pharmacokinetics ; Drug Evaluation, Preclinical - methods ; first-pass effect ; Fluorouracil - blood ; Fluorouracil - pharmacokinetics ; General pharmacology ; hepatic metabolism ; intestinal absorption ; Liver - blood supply ; Liver - metabolism ; local moment analysis ; Male ; Medical sciences ; Models, Biological ; Models, Chemical ; pharmacokinetic ; Pharmacokinetics. Pharmacogenetics. 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A new recirculatory system was constructed to predict the time courses of a drug concentration in the systemic and portal bloods. Bioavailability (F), local absorption ratio (Fa), hepatic recovery ratio (FH), and local mean absorption time (¯ta) estimated by recirculatory analysis were close to those calculated by moment analysis with numerical integration. Using recirculatory analysis, the sampling period was considerably shortened and the sampling number was also reduced, which demonstrates that recirculatory analysis is useful in PS-DD method.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biological Availability</subject><subject>Cephalexin - blood</subject><subject>Cephalexin - pharmacokinetics</subject><subject>Drug Evaluation, Preclinical - methods</subject><subject>first-pass effect</subject><subject>Fluorouracil - blood</subject><subject>Fluorouracil - pharmacokinetics</subject><subject>General pharmacology</subject><subject>hepatic metabolism</subject><subject>intestinal absorption</subject><subject>Liver - blood supply</subject><subject>Liver - metabolism</subject><subject>local moment analysis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Models, Biological</subject><subject>Models, Chemical</subject><subject>pharmacokinetic</subject><subject>Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions</subject><subject>Pharmacology. Drug treatments</subject><subject>Portal System - metabolism</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>recirculatory analysis</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkMlvEzEYxS0EomngxB1ZQvSCpngbL8cStkpFIJaz5fFCHU3GwfYc8t_jkFEqcfgW2T-9Zz8AXmB0jQmTb4f9cE1Y25V8BFaYMtH1BPePwQopLDuOe3kBLkvZIoQEIvQpuMBYkF5xuQL6dqo5udnWmCaYAvzubcx2Hk1N-QBvJjMeSiwwTjXBbylXM0IzOfjjUKrfRQs3abK-aZh_Au9jCD77dgS_-Hqf3DPwJJix-OfLXINfHz_83Hzu7r5-ut3c3HWWSVG7QQ3cSskdFUEZGQIXjHOuhMCBD05ZjJAl1AnHDEUBMUUCom5wyFAsW1uDq5PuPqc_sy9V72KxfhzN5NNctCAU9RSxBr76D9ymObdvFo0ZU1hR3moN3pwom1Mp2Qe9z3Fn8kFjpI-p65a6JkwfU2_0y0VzHnbePbBLzA14vQCmWDOGbCYbywPHMOKEHB_37sRtSzW__RkwuUY7-rMpXvrR_Xxp703WfqJ_AelQoeM</recordid><startdate>20011101</startdate><enddate>20011101</enddate><creator>UEDA, Shinya</creator><creator>YAMAOKA, Kiyoshi</creator><creator>SAWAI, Yoneichi</creator><creator>NAKAGAWA, Terumichi</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><general>Japan Science and Technology Agency</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20011101</creationdate><title>Introduction of Recirculatory Analysis into Portal and Systemic Concentration Difference Method</title><author>UEDA, Shinya ; YAMAOKA, Kiyoshi ; SAWAI, Yoneichi ; NAKAGAWA, Terumichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-b9b6c886d37f9a8ff6746669771f6bd9c100c23d7d4a30f0492f03dbd0a3180a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biological Availability</topic><topic>Cephalexin - blood</topic><topic>Cephalexin - pharmacokinetics</topic><topic>Drug Evaluation, Preclinical - methods</topic><topic>first-pass effect</topic><topic>Fluorouracil - blood</topic><topic>Fluorouracil - pharmacokinetics</topic><topic>General pharmacology</topic><topic>hepatic metabolism</topic><topic>intestinal absorption</topic><topic>Liver - blood supply</topic><topic>Liver - metabolism</topic><topic>local moment analysis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Models, Biological</topic><topic>Models, Chemical</topic><topic>pharmacokinetic</topic><topic>Pharmacokinetics. 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A new recirculatory system was constructed to predict the time courses of a drug concentration in the systemic and portal bloods. Bioavailability (F), local absorption ratio (Fa), hepatic recovery ratio (FH), and local mean absorption time (¯ta) estimated by recirculatory analysis were close to those calculated by moment analysis with numerical integration. Using recirculatory analysis, the sampling period was considerably shortened and the sampling number was also reduced, which demonstrates that recirculatory analysis is useful in PS-DD method.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>11725968</pmid><doi>10.1248/bpb.24.1298</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Administration, Oral Animals Biological and medical sciences Biological Availability Cephalexin - blood Cephalexin - pharmacokinetics Drug Evaluation, Preclinical - methods first-pass effect Fluorouracil - blood Fluorouracil - pharmacokinetics General pharmacology hepatic metabolism intestinal absorption Liver - blood supply Liver - metabolism local moment analysis Male Medical sciences Models, Biological Models, Chemical pharmacokinetic Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Portal System - metabolism Rats Rats, Wistar recirculatory analysis |
| title | Introduction of Recirculatory Analysis into Portal and Systemic Concentration Difference Method |
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